1. Hematology Block: Overview and Advice Tim Boswell, M4 Presentation created on 3/21/16

2. Organ Systems and Scientific Disciplines Physiology Pathophysiology Pathology Microbiology Pharmacology

3. Major Areas Anemias Coagulation Disorders Hematological Malignancies

4. Functions -> Diseases Transportation throughout body oxygen and nutrients waste Flow well in vessels, but not leak out if a vessel is opened Regulation/homeostasis/defense Anemias Coagulation Disorders Malignancy

5. Components -> Diseases Blood Red blood cells Anemias Iron deficiency anemia Anemia of Chronic Disease Thalassemias Sideroblastic Anemia Aplastic Anemia Hereditary spherocytosis Sickle Cell Anemia Folate Deficiency B12 Deficiency G6PD Deficiency Hemolytic of various types Polycythemia vera

6. Components -> Diseases Blood Red blood cells White blood cells Immune deficiencies and leukopenias Malignancies Leukemias Acute myelogenous leukemia (AML) Chronic myelogenous leukemia (CML) Acute lymphocytic leukemia (ALL) Chronic lymphocytic leukemia (CLL) Lymphomas Follicular Lymphoma Burkitt Lymphoma Diffuse Large B-cell Lymphoma Plasma cell disorders Multiple myeloma Waldenstrom’s macroglobulinemia

7. Components -> Diseases Blood Red blood cells White blood cells Platelets Thrombocytopenia Immune Thrombocytopenia Purpura (ITP) Thrombotic (TTP) Platelet dysfunction Bernard Soulier Glanzman’s thrombasthenia Metabolic Essential Thrombocythemia

8. Components -> Diseases Blood Red blood cells White blood cells Platelets Plasma (water + proteins, electrolytes) Coagulopathy (bleeding) Hemophilia A and B Von Willebrand’s disease Vitamin K deficiency DIC Thrombophilia (clotting) Factor V Leiden Protein C and S deficiency Antithrombin III deficiency Antiphospholipid antibody syndrome Heparin Induced Thrombocytopenia (HIT) Acidosis/Alkalosis Electrolyte abnormalities

9. Components -> Diseases Blood Red blood cells White blood cells Platelets Plasma (water + proteins, electrolytes, wastes) Other Organs Lymph nodes, spleen, bone marrow

10. Covering the disciplines Microbiology Herpes viruses (CMV, EBV, etc.) HIV Hemorrhagic fever viruses Pharmacology Anticoagulants Antiplatelets Antineoplastic agents Antiretrovirals

11. Advice Physiology to pathophysiology Organize the topics Utilize resources (assigned textbook, Pathoma, First Aid, Goljan audio, Webpath questions, Robbins question book) Keep a list of the CDs (CD4, CD20, etc.) and know the ones that are emphasized Anticipate the final week The End