1. NIH Institutional Training Grants (T-32) Pre-Award October 15, 2013 Becky Bound, CALS Research Division Jenny Dahlberg, School of Veterinary Medicine Jane Lambert, Department of Population Health Sciences

2. T32 Overview Definition Essential websites Application: Tables & Timeline

3. T32 grants: What do they support? research training experiences predoctoral, postdoctoral, and short-term trainees specified areas of biomedical, behavioral and clinical research

4. T32 grants: Whom do they support? U.S. citizens permanent residents of the U.S.

5. T32 grants: How do they operate? institutional awards (not individual fellowships) Program director applies on behalf of group of faculty trainers. internal review process to award “slots” to individual trainees

6. T32 grants: How do you know if you should apply? All Applicants (new and renewal): PI: Call the Program Officer of your current or prospective Institute. Discuss: your grant + mission of the NIH institute = good fit? Does the Institute have unique policies, requirements, application tables/forms?

7. T32 grants: How do you know if you should apply? New T32 applicants: Your trainers must be unique group of faculty representing area not covered by any other T32 on campus. Review the campus T32 list and contact colleagues with questions: UW T32 list: http://www.grad.wisc.edu/research/traininggrants/nihtra ining.html UW T32 list: http://www.grad.wisc.edu/research/traininggrants/nihtra ining.html

8. Essential Websites: UW Grad School List of T32 grants on campus: http://www.grad.wisc.edu/research/traininggrants/nih training.html http://www.grad.wisc.edu/research/traininggrants/nih training.html Helpful information for administering a training grant (general info, T32 presentations, Xtrain, NRSA pre ‐ and post ‐ doc fellowships, tuition/fees shortfall, campus resources): http://www.grad.wisc.edu/research/traininggrants/nih info.html http://www.grad.wisc.edu/research/traininggrants/nih info.html T32 database: https://t32database.wisc.edu/login/index.asp https://t32database.wisc.edu/login/index.asp

10. Essential Websites: NIH Ruth L. Kirschstein National Research Service Award (NRSA) http://grants.nih.gov/training/nrsa.htm http://grants.nih.gov/training/nrsa.htm “T Kiosk” Information about NRSA Institutional Training Grant Funding Opportunities: http://grants.nih.gov/training/T_Table.htm http://grants.nih.gov/training/T_Table.htm T32 Institutional Research Training Grant Program Announcement: http://grants.nih.gov/grants/guide/pa-files/PA-11-184.html http://grants.nih.gov/grants/guide/pa-files/PA-11-184.html T32 Data Tables Instructions (scroll down to "Table of Contents for this Page," then 3rd bullet): http://grants.nih.gov/grants/funding/424/index.htm http://grants.nih.gov/grants/funding/424/index.htm Institute ‐ and Center ‐ Specific Information, Requirements and Staff Contacts: http://grants.nih.gov/grants/guide/contacts/parent_T32.html http://grants.nih.gov/grants/guide/contacts/parent_T32.html NRSA Research Training Grants FAQs: http://grants.nih.gov/training/faq_training.htm http://grants.nih.gov/training/faq_training.htm NIH policy on applications that request $500,000 or more in direct costs for any year: http://grants.nih.gov/grants/guide/notice-files/not-od-02-004.html

11. Ruth L. Kirschstein NRSA (National Research Service Award) Website: http://grants.nih.gov/training/nrsa.htm T-Kiosk: Program Announcement Application Kit: SF424 (R&R) “ADOBE- FORMS-C” Institute-specific contacts & instructions FAQ (and more!) Essential Websites: NIH

12. NRSA Website: http://grants.nih.gov/training/nrsa.htmhttp://grants.nih.gov/training/nrsa.htm

13. T Kiosk: Program Announcement Listings

14. Program Announcement: http://grants.nih.gov/grants/guide/pa-files/PA-11-184.html http://grants.nih.gov/grants/guide/pa-files/PA-11-184.html

15. Tables Tables are the most closely reviewed section of the application! Data needs to be as complete as possible. See “Campus Sources of Data” list.

16. Tables NIH T32 Data Tables Instructions – http://grants.nih.gov/grants/funding/424/index.htm #data

17. Table 1Table 1 Membership of Participating Departments/Programs (new apps) Table Table 1 Membership of Participating Departments/Programs (renewal/revision apps) Table Table 2 Participating Faculty Members Table 3Table 3 Institutional Training Grant Support Available to Participating Faculty Members, Departments, or Programs Table 4Table 4 Grant and Contract Support of the Participating Faculty Members

18. Table 5Table 5A Predoctoral Trainees of Participating Faculty Members Table 5Table 5A Postdoctoral Trainees of Participating Faculty Members Table 6Table 6A Publications of Research Completed by Predoc Trainees (new apps) Table 6B Publications of Research Completed by Postdoc Trainees (new apps)Table 6 Table 6A Publications of Research Completed by Predoc Trainees (renewal apps) Table 6B Publications of Research Completed by Postdoc Trainees (renewal apps)Table 6

19. Table 7ATable 7A Admissions and Completion Records for the Participating Departments and Programs During the Past Five Years (Predoctoral Applicants) Table 7BTable 7B Admissions and Completion Records for the Participating Departments and Programs During the Past Five Years (Postdoctoral Applicants) Table 8ATable 8A Qualifications of Recent Predoctoral Applicants Table 8BTable 8B Qualifications of Recent Postdoctoral Applicants

20. Table 9ATable 9A Qualifications of the Current Predoctoral Trainees Clearly Associated with the Training Program Table 9BTable 9B Qualifications of the Current Postdoctoral Trainees Clearly Associated with the Training Program

21. Table 10Table 10 Admissions and Completion Records for Underrepresented Minority (URM), Trainees with Disabilities, and Trainees from Disadvantaged Backgrounds Clearly Associated with the Training Program (Renewal apps; optional for new apps) Table 11Table 11 Appointments to the Training Grant For Each Year of the Past Award (Renewal Applications Only)

22. Table 12ATable 12A Predoctoral Trainees Supported by this Training Grant (Renewal Applications Only) Table 12BTable 12B Postdoctoral Trainees Supported by this Training Grant (Renewal Applications Only)

23. Recommended Timeline At least 5 months prior to deadline, determine faculty trainer list & review information available in the T32 database to determine what additional data you must collect from faculty trainers. Enter new information and updates into the T32 database as you collect it.

24. Recommended Timeline: Renewals For renewal applications, at least three months prior to deadline request current trainee research descriptions and publication lists and gather trainee history data.

25. Recommended Timeline: Interdept Grants For interdepartmental training grants, at least two months prior to deadline request departmental data (information on applicant pool, current positions of past trainees).

26. Recommended Timeline: Review & Approval Contact Dean’s Office for budget review during the month prior to the deadline. Ask Dean’s Office for preferred timeline for routing Cayuse application and WISPER record.

27. Other Timeline Tips Check the T32 database to see what data is already available. For large grants, try to get extra help with data entry for the 8 weeks prior to deadline.

28. Creating a Budget - Stipends Current rates posted on NIH website: http://grants.nih.gov/grants/guide/notice- files/NOT-OD-12-033.html http://grants.nih.gov/grants/guide/notice- files/NOT-OD-12-033.html (FY12 rates still applicable per NOT-OD-13-064) Predoctoral $22,032 Postdoctoral Years of Experience 0 $39,264 1 $41,364 2 $44,340 3 $46,092 4 $47,820 5 $49,884 6 $51,582 7 or more $54,180

29. Tuition & Seg. Fees: Sample Calculations

30. Creating a Budget Trainee Travel – Check with your awarding component for their policy on this category Training Related Expenses including Health Insurance Training Related Expenses: Funds to help defray expenses including staff salaries, equipment, and supplies. Request $2,200 per predoc and $3,850 per postdoc. Health Insurance: Current rates are available at https://www.rsp.wisc.edu/rates/index.html. Predoc Trainees: 24.2% Postdoc Fellows/Trainees: 14.5% Request actual costs and budget future year increases. NIH will limit the amount awarded to $2,000 per predoctoral trainee and $4,000 per postdoctoral trainee

31. Training Related Expenses Calculation Per Year Predocs Health Insurance(($22,032 x 25.2%) x 25 slots) = $ 133,434.00 Trainee Related Expenses$2,200 x 25 slots = $ 55,000.00 TOTAL $ 188,434.00 Postdocs Health Insurance [(($39,264 x 15.5%) x 2 slots) + (($41,364 x 15.5%) x 2 slots)] = $ 24,995.00 Trainee Related Expenses $3,850 x 4 slots = $ 15,400.00 TOTAL $ 40,395.00 GRAND TOTAL $ 228,829.00

32. Creating a Budget Facilities and Administrative Costs (also called indirect costs or overhead) should be requested at a rate of 8% of total direct costs less tuition, fees, and equipment. CategoryCost Stipends $ 712,056 Travel $ 29,000 Training Related Expenses $ 228,829 Tuition and Fees $ 716,809 Total Direct Costs (TDC) $ 1,686,694 Modified Total Direct Costs (MTDC = TDC less Tuition) $ 969,885 Indirect Costs (8% of MTDC) $ 77,591

33. Cayuse…. Budget – Use the worksheet (it helps!) Check that all Indirect Cost Type fields are set to “MTDC” Change F&A rate to 8% Double check auto calculations Data Tables: Attach Separately! Cayuse will combine them into 1 attachment for you. Key Personnel: DON’T create profiles for anyone else on campus in Cayuse! Request profile permissions instead.

34. PHS 398 Training Budget, Period 1 Stipends will pull from table within Cayuse

35. PHS 398 Training Budget, Period 1

36. PHS 398 Training Budget, Summary and Escalation

37. Budget Justification Explain how budget numbers were calculated and escalated: Stipend levels used Tuition per trainee per year TRE (fringe rate plus $2200 or $3850/trainee) Indirect costs

38. Shortfall (your award will not cover the full costs) Predoctoral Trainees Graduate School will cover the tuition, fees, and fringes shortfall on NIH training grants. For details, see memo at http://www.grad.wisc.edu/research/traininggrants/documents/Tuitio nRemissionGraduateFellows61609.final.pdf For each trainee, the Training Related Expenses (TRE) category must still cover at least $2,000 of his or her health insurance costs Postdoctoral Trainees Individual departments/programs are responsible for covering any shortfall. This means departments/programs should save enough TRE to cover health insurance costs for all postdoctoral trainees.

39. Shortfall (your award will not cover the full costs) Predoctoral Trainees Graduate School will cover the tuition, fees, and fringes shortfall on NIH training grants. For details, see memo at http://www.grad.wisc.edu/research/traininggrants/documents/Tuitio nRemissionGraduateFellows61609.final.pdf For each trainee, the Training Related Expenses (TRE) category must still cover at least $2,000 of his or her health insurance costs Postdoctoral Trainees Individual departments/programs are responsible for covering any shortfall. This means departments/programs should save enough TRE to cover health insurance costs for all postdoctoral trainees.

40. Other Mandated Proposal Sections Minority Recruitment Plan http://www.nigms.nih.gov/Training/Diversity/ Training in Responsible Conduct of Research http://grants.nih.gov/training/responsibleconduct.htm

41. Other Mandated Proposal Sections Minority Recruitment Plan Both Departmental/Program and University efforts are important. AOF/GRS Communities (Advanced Opportunity Fellowships/Graduate Research Scholar Communities) SROP Students (Summer Research Opportunity Program) Graduate School Fairs BOPs (Bioscience Opportunities Preview Program) Department/Program Website and/or Committee K-12 Outreach (PEOPLE Program, etc.) Faculty Travel for Recruitment Faculty Mentoring of Students (McNair, URS, etc.) Recruitment Mailings

42. Other Mandated Proposal Sections Training in Responsible Conduct of Research: Frequency and Format Frequency (some NIH Institutes require training every year) On campus courses Bacteriology 901 (Responsible Conduct of Research) Chemistry 901 (Seminar in Scientific Ethics) Horticulture 875 (Intro to Research Ethics) Human Oncology 721 (The Conduct of Science) Various Medical History & Bioethics Medical Physics 471 (Ethics & Responsible Conduct of Research) Nursing 802 (Ethics & Conduct of Research) Oncology 675 (Appropriate Conduct & Effective Comm of Sci) Pharmacy 800 (Research Ethics) Surgical Sciences 812 (Research Ethics and Career Development) Program/Departmental training Seminars/Workshops-on or off campus

43. Other Considerations Letters of Support Not required Letters may be requested from Graduate School or home school/college to document promised support. Key Personnel Should typically only include PI and co-directors. Biosketches Use standard NIH biosketch including the personal statement-with statement relevant to training history Biosketches for faculty key personnel will appear twice. Once under key personnel and a second time in the participating faculty biosketch section. Be sure all NIH funded publications complies with NIH Public Access Policy (PMCIDs) listed in biosketches Appendix may include samples of materials referred to in the text.

44. Regulatory Compliance Financial Conflict of Interest The Program Director must complete a disclosure form prior to submission of the application http://www.rsp.wisc.edu/coi/index.html Human Subjects/Biological Materials/Vertebrate Animals/Human Embryonic Stem Cells Updated procedures are available on the T32 web site http://www.grad.wisc.edu/research/traininggrants/animalhumanbiol.html

45. Regulatory Compliance- PLuS Database UW protocol numbers are listed in the PLuS (Protocol Lookup System), a database developed by the Graduate School. To request access to this database, contact Heather McFadden (hnmcfadden@grad.wisc.edu) in the Graduate School's Office of Research Policy. This database will provide you with protocol numbers and approval dates for your PIs. You may use this resource, as well as communication with your trainers to determine the list of protocol details to be provided to NIH and entered in WISPER.

46. Regulatory Compliance–Human Subjects If Human Subjects are used in any of the research related to the training grant, the Program Director must complete the Human Subjects training module http://www.grad.wisc.edu/hrpp/10222.htm Any trainers and trainees involved should also complete the training module.

47. Regulatory Compliance Human Subjects/Biological Safety/Vertebrate Animals/Human Embryonic Stem Cells Umbrella protocols should no longer be used. In the WISPER record, check "Yes" for those clearances that are applicable. You can either list protocols associated with the training grant at this point or wait until the time of award. If you wish to list the protocols at this time, create a table in Microsoft Excel and upload it as an attachment to WISPER. Biosafety is required, but is for internal use.

48. The WISPER Record For document type, choose NIH Train. Pick submission method as Cayuse. No need to attach any 424 forms to record although your Dean’s office may want to attach an excel spreadsheet on your budget calculations. Route record per usual.

49. Off to NIH for Review T32 applications will follow the general Peer Review Process. Site visit (if held) will be approximately 6 months from submission deadline.

50. Preparing for the Site Visit WHAT WILL THEY DO? ARE THEY GOING TO INTERROGATE ME AND BEAT ME UP?! ARE THEY GOING TO BREAK MY KNEES???

51. Agenda for GM07215 Training Grant Site Visit Oct. 29, 2008 E.B. Fred Conference Room, Microbial Sciences 8:00-9:30 Program Director, Steering Committee, Administrator, Associate Dean of Graduate School, Associate Dean for CALS, Associate Dean for SMPH 9:30-9:45 Executive Session 9:45-10:15 Participating Faculty – Junior Members 10:15-10:45 Participating Faculty – Senior Members 10:45-11:45 First and Second Year Students 11:45-12:15 Lunch/Executive Session 12:15-1:15 Third and Fourth Year Students 1:15-2:15 Fifth and Sixth Year Students 2:15-2:45 Alumni Session 2:45-3:00Executive Session 3:00-3:15 Wrap up with Program Director and Administrator

52. Student Profile Form Name ________________ Department __________________ Trainer _________________ Year of Grad. Study ________ Source(s) of Support _______________________________ Education: Institution ________________________ Degree _____ Yr _____ Major ______ Undergrad GPA ______ GRE Scores: V ____ Q ____ Analyt _____ Adv _____ Subj _____ Honors ____________________________________________________________________ Teaching Experience _________________________________________________________ Research Experience (before commencing Graduate Study) __________________________ Other Graduate Programs (Universities) Applied to (and Outcomes) ___________________ Laboratory Rotations _________________________________________________________ Current Research Activities ___________________________________________________ Courses Taken (this Graduate Program) __________________________________________ Postdoctoral Training Applied for: Institution Sponsor Research Area Offer Made Offer Accepted __________________________________________________________________________ Publications _______________________________________________________________

53. Your Score Rocked and Your Award Has Arrived!

54. WISPER Record Updates-Protocols Compile list of human subjects, stem cells, biological safety and vertebrate animal protocols for trainees that will be appointed to grant. Each protocol list should be in an excel table. Include tables as attachments in WISPER record.

55. New Financial Conflict of Interest Requirements Key personnel must complete training requirement through Learn@UW. (course name Conflict of Interest Training) Key personnel must update their outside activity report http://www.grad.wisc.edu/coi/disclose.html Key personnel must update outside activity report within 30 days if they Travel either reimbursed or sponsored and related to their institutional duties. Travel that is reimbursed or sponsored by a Federal, state, or local government agency, a U.S.-based institution of higher education, an academic teaching hospital, a medical center, or a research institute that is affiliated with a U.S.- based institution of higher education does not need to be reported. Have a new outside financial interest.

56. WISPER Record Updates- Project Set Up For Project Type: choose GM_20 for Research Training Program For FA Base: choose NIH Training For program codes, choose 2, 9 and 4 (4- postdocs only) Set up cost shared effort for PI and other key personnel. This is typically 1-5%. Enter cost share source.

57. WISPER Record Updates- Project Set Up If award is a new or competing continuation award, RSP will set up accounts for all years of the grant at one time. Set up a new project for each funding period. This will remind and alert RSP that they will need to set up several account numbers at once. Enter project details for each project period.

58. Other T32 Resources at UW-Madison Training Grant Administrators Networking Group (Contact Jane Lambert or Jenny Dahlberg) T32 ListServ ntp-T32@lists.services.wisc.edu (Contact Jenny Dahlberg jmdahlberg@wisc.edu)

59. Upcoming NIH Institutional Training Grant Seminars Oct 29, 2013 How to apply for NIH fellowships (11am-12:30, 1360 Genetics biotech) March or April 2014 TBA-Administration of Predoc or Postdoc NRSA Individual Fellowship April 15, 2014-NIH Institutional Training Grants: Post-Award Issues Seminar Register at the Office of Human Resource Development website: www.ohrd.wisc.edu (look in catalog under Research Administration).www.ohrd.wisc.edu

60. Contact Information Becky Bound rbound@cals.wisc.edu Jenny Dahlberg jmdahlberg@wisc.edu Jane Lambert jflamber@wisc.edu

61. Questions? ??? Thanks for coming!! Evaluations will be sent electronically.