1. Chapter 4 Organization and Regulation of Body Systems

2. Points to Ponder What is a tissue? Organ? Organ system? What are the 4 main types of tissue? What do these tissues look like, how do they function and where are they found? What is the integumentary system? How can you prevent skin cancer? What is homeostasis and how is it maintained?

3. What is a tissue? A collection of cells of the same type that perform a common function There are 4 major tissue types in the body: 1.Connective 2.Muscular 3.Nervous 4.Epithelial 4.1 Types of tissues

4. 4.1 Types of Tissues Cancers are classified according to the type of tissue from which they arise: a.Sarcomas—cancers of bone and cartilage. b.Leukemia—cancers of the blood. c.Lymphomas—cancers of the lymphoid tissue. d.Carcinomas—cancers of the epithelial tissue. 4-3

5. 4. Epithelial tissue A groups of cells that form a tight, continuous network Lines body cavities, covers body surfaces, and found in glands Cells are very close together No blood vessels Tissue is very thin Sits on connective tissue 4.5 Epithelial tissue protects

6. How do we name epithelial tissue? Number of cell layers: Simple: one layer of cells Stratified: more than one layer of cells Pseudostratified: appears to have layers but only has one layer Shape of cell: Cuboidal: cube-shaped Columnar: column-shaped Squamous: flattened 4.5 Epithelial tissue protects

7. What does epithelial tissue look like? 4.5 Epithelial tissue protects

8. 1. Connective tissue Binds and supports parts of the body All have specialized cells, ground substance, and protein fibers Ground substance is noncellular and ranges from solid to fluid The ground substance and proteins fibers together make up the matrix of the tissue Does have blood vessels 4.2 Connective tissue connects and supports

9. 3 main types of connective tissue A. Fibrous B. Supportive C. Fluid 4.2 Connective tissue connects and supports

10. A. Fibrous connective tissue There are two types: dense or loose, but both contain fibroblast cells with a matrix of collagen and elastic fibers Loose fibrous tissue is found supporting epithelium and many internal organs Adipose tissue is a special loose fibrous tissue where fat is stored 4.2 Connective tissue connects and supports

11. What does loose fibrous connective tissue look like? 4.2 Connective tissue connects and supports

12. B. Supportive connective tissue: Cartilage Cells are in chambers called lacunae Matrix is solid but flexible 3 types are distinguished by types of fibers 1.Hyaline cartilage – fine collagen fibers Location: Nose, ends of long bones and fetal skeleton 2.Elastic cartilage – more elastic fibers than cartilage fibers Location: Outer ear 3.Fibrocartilage – strong collagen fibers Location: Disks between vertebrae 4.2 Connective tissue connects and supports

13. B. Supportive connective tissue: Bone Cells are in chambers called lacunae Matrix is solid and rigid that is made of collagen and calcium salts 2 types are distinguished by types of fibers 1.Compact – made of repeating circular units called osteons which contain the hard matrix and living cells and blood vessels Location: Shafts of long bone 2.Spongy – an open, latticework with irregular spaces Location: Ends of long bones 4.2 Connective tissue connects and supports

14. What do bone and cartilage look like? 4.2 Connective tissue connects and supports

15. C. Fluid connective tissue: Blood Made of a fluid matrix called plasma and cellular components that are called formed elements 3 formed elements: 1.Red blood cells – cells that carry oxygen 2.White blood cells – cells that fight infection 3.Platelets – pieces of cells that clot blood 4.2 Connective tissue connects and supports

16. C. Fluid connective tissue: Lymph Matrix is a fluid called lymph White blood cells congregate in this tissue 4.2 Connective tissue connects and supports

17. 2. Muscle tissue Allows for movement in the body Made of muscle fibers/cells and protein fibers called actin and myosin There are 3 types of muscle tissue in humans: A. Skeletal B. Smooth C. Cardiac 4.3 Muscle tissue moves the body

18. A. Muscle tissue - Skeletal Appearance: long, cylindrical cells, multiple nuclei, striated fibers Location: attached to bone for movement Nature: voluntary movement 4.3 Muscle tissue moves the body

19. B. Muscle tissue - Smooth Appearance: spindle- shaped cell with one nucleus, lack striations Location: walls of hollow organs and vessels Nature: involuntary movement 4.3 Muscle tissue moves the body

20. C. Muscle tissue – Cardiac Appearance: branched cells with a single nucleus, striations with darker striations called intercalated disks between cells Location: heart Nature: involuntary movement 4.3 Muscle tissue moves the body

21. 3. Nervous tissue Allows for communication between cells through sensory input, integration of data, and motor output Made of 2 major cell types: A. Neurons B. Neuroglia 4.4 Nervous tissue communicates

22. A. Nervous tissue - neurons Made of dendrites, a cell body and an axon Dendrites carry information toward the cell body Axons conduct nerve impulses 4.4 Nervous tissue communicates

23. A. Nervous tissue - neuroglia A collection of cells that support and nourish neurons Outnumber neurons 9:1 Examples are oligodendrocytes, astrocytes, and microglia 4.4 Nervous tissue communicates

24. Moving from tissue to organs and organ systems An organ is 2 or more tissue types working towards a particular function An organ system is a combination of organs that work together to carry out a particular function 4.7 Integumentary system

25. What are the body cavities? 4.8 Organ systems

26. What are the organ systems of the human body? 4.8 Organ systems

27. What are the organ systems of the human body? 4.8 Organ systems

28. What about the body membranes that line the cavities? Mucous membranes – lining of the digestive, respiratory, urinary and reproductive systems Serous membranes – line lungs, heart, abdominal cavity and covers the internal organs; named after their location Pleura: lungs Peritoneum: abdominal cavity and organs Pericardium: heart Synovial membranes – lines the cavities of freely movable joints Meninges – cover the brain and spinal cord 4.8 Organ systems

29. What is homeostasis? The ability to maintain a relatively constant internal environment in the body The nervous and endocrine systems are key in maintaining homeostasis Changes from the normal tolerance limits results in illness or even death 4.9 Homeostasis

30. The integumentary system: Includes the skin and accessory organs such as hair, nails, and glands The skin has two main regions called the epidermis and the dermis Under the skin there is a subcutaneous layer between the dermis and internal structures where fat is stored Is important for maintaining homeostasis 4.7 Integumentary system

31. What are the functions of the integumentary system 1.Protects the body from physical trauma, invasion by pathogens, and water loss 2.Helps regulate body temperature 3.Allows us to be aware of our surroundings through sensory receptors 4.Synthesizes chemicals such as melanin and vitamin D 4.7 Integumentary system

32. There are two regions of the skin Epidermis Dermis 4.7 Integumentary system

33. The epidermis: The thin, outermost layer of the skin Made of epithelial tissue Cells in the uppermost region are dead and become filled with keratin thus acting as a waterproof barrier Langerhans cells are a type of white blood cell that help fight pathogens Melanocytes produce melanin that lend to skin color and protection for UV light Some cells convert cholesterol to vitamin D 4.7 Integumentary system

34. What might skin cancer look like? 4.7 Integumentary system

35. The dermis: The thick, inner layer of the skin Made of dense fibrous connective tissue Contains elastic and collagen fibers Contains blood vessels, many sensory receptors and glands 4.7 Integumentary system

36. What are the accessory organs of the skin and why are they important? Includes nails, hair, and glands Nails are derived from the epidermis and offer a protective covering Hair follicles are derived from the dermis, but hair grows from epidermal cells Oil glands are associated with hair and produce sebum that lubricates hair and skin as well as retards bacterial growth Sweat glands are derived from the dermis and helps to regulate body temperature 4.7 Integumentary system

37. Accessory Organs of the Skin Nails. –Nail root –Nail body –Lunula –Cuticle –Nail bed

38. Skin disorders Acne vulgaris –Infection of sebaceous glands caused by a bacterium –Most notable after puberty, when high amounts of sex hormones stimulate increased sebum production –An association between acne and food has not been firmly established. Eating chocolate does not cause acne. Papule - firm, raised bump Pustule - papule filled with pus Boils –Cause by bacterium Staphylococcus aureus which is a skin resident Abscess - An abscess is a pocket of inflamed tissue that contains pus, white blood cells, and tissue fluid.

39. Skin Disorders Warts - caused by human papillomaviruses- HPV –Transmitted person to person by contact –Infection of epidermal cells –Skin warts-- virus may disappear –Genital warts Viruses remain in body, and outbreaks may recur Leading cause of cervical cancer in women Tinea –General name for many fungal infections including Ringworm jock itch athlete’s foot

40. Skin Cancers Basal cell carcinoma a. Begins in the stratum basale b. Spreads to dermis and hypodermis c. Produce slow-growing nodules d. Surface of skin has scaly ulcer with beaded border e. Rarely metastasizes f. Treated with surgery

41. Basal Cell Carcinoma

42. Skin Cancers Squamous-cell carcinoma a. Develops in sun-exposed keratinocytes b. Form raised, hard, scaly, red nodules c. Grows rapidly and may spread to dermis and underlying tissues d. Early surgery and radiation are effective treatments

43. Squamous Cell Carcinoma

44. Skin Cancers MALIGNANT MELANOMA a. Begins in melanocytes, often from a pre-existing mole b. Most common in fair-skinned individuals c. Quickly metastasizes to neighboring lymph nodes and internal organs d. Early recognition can lead to successful removal by means of surgery and radiation therapy. e. After metastasis, treatment is difficult, and death may follow

45. Melanoma Risk of melanoma –In 1935: 1/11500 –In 1992: 1/105 –In 2000: 1/75 –Risk is increasing The percentage of patients under the age of 30 who regularly use tanning beds may have nearly 8X greater risk of melanoma than those who never use tanning beds

46. Melanoma

47. What might skin cancer look like? 4.7 Integumentary system

48. ABCD rule: A: Asymmetry-- the two sides of the lesion are different B: Border irregularity-- the borders are irregularly scalloped C: Color varies-- may include shades of brown, tan, black, red, white, or blue D: Diameter-- greater than 6mm or the size of a pencil eraser E: Elevation-- change in height F: Feeling-- itch, burn, pain, or tenderness

49. What can you do to help prevent this? Stay out of the sun between 10am-3pm Wear protective clothing (tight weave, treated sunglasses, wide-brimmed hat) Use sunscreen with an SPF of at least 15 and protects from UV-A and UV-B rays Don’t use tanning beds