1. AP Biology Biochemistry: Macromolecules Part 3

2. Nucleic Acids A. Monomers are called Nucleotides B. Polymers are called DNA or RNA- It depends on the 5 Carbon sugar present in the monomer. DNA has Deoxyribose for the 5 Carbon sugar. RNA has Ribose for the 5 Carbon sugar. C. These are the source of genes and hereditary information primarily.

3. Monosaccharides of Nucleic Acids

4. Two Types DNA – This polymer is the “Master Million Dollar Blueprint”. It is kept “safe” in the nucleus. (Nucleus is like a vault to keep the DNA in.) RNA – This polymer is like a “cheap 10 cent copy” of the “Master Million Dollar Blueprint”. It is disposable/recyclable. It makes messenger RNA and other RNA molecules.

5. DNA vs. RNA nucleotides Remember, DNA is long term; RNA is temporary

6. Nucleic Acids (DNA)

7. Nucleic Acids (RNA)

8. Pyrimidines (C, T, U) – Big name small molecule. (These have 1 Carbon ring in the Nitrogen base.) – “Counting steps Takes you Up the Pyramid” is the easy way to remember them. Purines (A, G,) – Small name big molecule. (These have 2 Carbon rings in the Nitrogen base.) – “Alabama is Purely Greater than Auburn” or “Auburn is Purely Greater than Alabama” is an easy way to remember. It just depends on who you like more.

9. Nucleotides

10. It is Always a pyrimidine paired with a purine.

11. Complimentary Base Pairing

12. See the HYDROGEN bonds? Remember, these are very important bonds.

13. Nucleotide sequence is important! Remember, DNA will make proteins.

14. Individual nucleotides joined by a covalent bond called a Phosphodiester bond. The phosphate of one nucleotide is joined with the 5 Carbon Sugar of the previous nucleotide. THE SEQUENCE DETERMINES WHAT PROTEIN OR ENZYME IS MADE Structure = Function and Emergent Properties are themes related to Nucleic Acids too. That is why it is the “BLUEPRINT”.

15. Dehydration and Hydrolysis Reactions Short polymer Unlinked monomer Dehydration removes a water molecule, forming a new bond Dehydration reaction in the synthesis of a polymer Longer polymer Hydrolysis adds a water molecule, breaking a bond Hydrolysis of a polymer

16. 5th Carbon of the Sugar holds the phosphate. 3 rd Carbon is the open bond. Phosphate of the next nucleotide bonds at the 3 rd carbon.

17. Phosphodiester Bonds of Nucleic Acids New strand 5 end Phosphate Base Sugar 3 end Nucleoside triphosphate

18. Phosphodiester bonds

19. DNA Double Helix Structure – James Watson and Francis Crick make the model in 1953. – The two sides of DNA strands are said to be complimentary. (They fit together perfectly.) – One side has information to make proteins and enzymes (The Million Dollar Blueprint); other side is a protective cap for the Million Dollar Blueprint. It protects the SEQUENCE of nucleotides. The sides alternate on each strand.

21. DNA Double Helix Structure

22. Watson and Crick

23. Blueprint vs. Protective Cap DNA Double Strand: ____________________________________ ______ Important “Blueprint” sequence ______ Protective “cap” sequence

24. Genes and Evolution  The more Nucleotide sequence “genes” in common; the more closely related the organisms are.  The fewer Nucleotide sequence “genes” in common: the more distantly related they are.

25. Genes and Evolution

26. Phosphorus Cycle The Phosphorus is initially a component of rock. As the rock breaks down over time, called weathering, the Phosphorus is released into the soil. Some dissolves into the water as the rains pass through the soil. This Phosphorus makes its way into bodies of water, such as lakes and oceans, and is available for producers (phytoplankton) to use to help make organic compounds such as phospholipids and DNA or RNA. Plants (also producers) can also retrieve the Phosphorus from the soil and use it to make organic compounds too. When organisms die, decomposers break down the bodies and return the Phosphorus back to the soil to be reused

27. The Phosphorus Cycle and Nucleic Acids and ATP Sedimentation Plants Rain Runoff Weathering of rocks Geologic uplift Soil Leaching Decomposition Plant uptake of PO 4 3– Consumption