1. André S Ferlauto – ferlauto@fisica.ufmg.br Laboratório de Nanomateriais Physics Department UFMG Meeting with Sumio Iijima - 2010

2. André S Ferlauto – ferlauto@fisica.ufmg.br Production and Applications of Carbon Nanotubes at Laboratório de Nanomateriais Physics Department- ICEX/UFMG Main Researchers Luiz Orlando Ladeira Rodrigo G. Lacerda André S Ferlauto 3 lab support 4 pos-doc 5 in PhD thesis 6 in Ms thesis 12 students

3. André S Ferlauto – ferlauto@fisica.ufmg.br Outline Timeline and Overview CNTs production CNT-based materials Biological applications of CNT

4. André S Ferlauto – ferlauto@fisica.ufmg.br 2000 SWNT by arc discharge CVD. - “large scale” MWNT - Over substrates (SWNT) “Large scale”production for internal market 2005 CT-Petro CNTs from natural gas PECVD VA-MWNT 2006 2003 Biological Applications Biocomposites of collagen/CNT Gene Transfection with CNT 2007 Partnerships: - Petrobrás (2008) - Supergesso (2008) - Plásticos Muller (2007) - Cimentos Cauê (2009) - Cemig (2009) 20082004 2009 Construction of new Lab Prod. over functional materials. Ex.: cement Timeline

5. André S Ferlauto – ferlauto@fisica.ufmg.br Different production lines: –MWNT by CVD –High Quality and Purity SWNT  Important for biological applications –MWNT e SWNT: controlled growth over substrates Main partnerships –Petrobrás: Polymer nanocomposites –Cimentos Cauê: Large Scale Production of MWNT “embedded” within the cement production process (patent application) –Supergesso: Plaster/CNT nanocomposites for odontological applications (patent application) Examples of applications already demonstrated: –Bio composite– Collagen/CNTs: tissue engineering and implants (patent application) –Bipolar plates for fuel cells (patent application - Electrocell) –Transfection of RNAi  Hybrid CNT/SiRNA as a control agent for fungal infection in agriculture “rust bean disease” (patent application) Production, Partnerships & Applications

6. André S Ferlauto – ferlauto@fisica.ufmg.br Facilities Production –2 Arc Discharge Reactors (1 under construction) –5 tubular furnaces for CVD –2 Reactors for PECVD (1 under construction) Processing –ultracentrifuge –oven –Microwave Reactor –Ultrasound Systems and Mixers –Chemical Processing Lab Characterization –Thermo gravimetric Analysis –Raman spectroscopy –UV-VIS-NIR spectroscopy

7. André S Ferlauto – ferlauto@fisica.ufmg.br Production of SWNT and MWNT Synthesis and purification of SWNT by arc discharge  High quality and purity SWNT for selected applications MWNT growth by ferrocene-based CVD  Low cost, “large scale” application for general use Vertically Aligned MWNT and controlled SWNT over different substrates  studies of electrochemical devices, photovoltaic, cell growth, etc. “Large scale” growth directly over commercial materials.

8. André S Ferlauto – ferlauto@fisica.ufmg.br CVD Production of long MWNT

9. André S Ferlauto – ferlauto@fisica.ufmg.br PECVD for Vertically aligned MWNT Growth of several substrate materials ► Metals (SS, Inconel) ► Glass + FTO ► Carbon paper / fibers ► Ceramics

10. André S Ferlauto – ferlauto@fisica.ufmg.br Direct CVD growth of CNT over functional materials Incorporation of CNT growth in pre-existing industrial processes  Cost reduction In-situ CNT growth over clinker cement Cheap sources of catalyst metals Possibility of ultra large scale process in the cement industrial plant (patent application)

11. André S Ferlauto – ferlauto@fisica.ufmg.br Increase on mechanical properties ( 38% in flexural strength) Very low cost Increase of thermal and electrical conductivity Direct CVD growth of CNT over functional materials ex: In-situ growth of CNT on clinker cement

12. André S Ferlauto – ferlauto@fisica.ufmg.br SEM image showing CNT and grains of cements

13. André S Ferlauto – ferlauto@fisica.ufmg.br CNT based materials ► Híbrids of CNTs and metal NPs ► CNTs thin films ► Plaster/CNT composites

14. André S Ferlauto – ferlauto@fisica.ufmg.br Híbrids CNT/Metal ACS Appl. Mater. Interfaces, 2009, 1 (10), pp 2104–2106, 2009 Patent application

15. André S Ferlauto – ferlauto@fisica.ufmg.br Thin films of CNTs Objective : transparent electrical conductive films Liquid spray deposition CNT + SDS solution CNT + starch solution

16. André S Ferlauto – ferlauto@fisica.ufmg.br 1 week 4 week Collagen-CNT bio composite for osteoregeneration induction Nano Research, v. 2, p. 462-473, 2009 1 Patent deposited Liofiliação

17. André S Ferlauto – ferlauto@fisica.ufmg.br In-Vivo experiment

18. André S Ferlauto – ferlauto@fisica.ufmg.br Just before the intervention30 days afther the intervention Em Tíbia X-ray radigraphy monitoring

19. André S Ferlauto – ferlauto@fisica.ufmg.br NTC - RNAsi Transfection Control CNT CNT + siRNA InsP3 R II Marina Ladeira Silvia Carolina G Fonseca CNT-RNAsi is a transfection agent RNA si M S Ladeira et al 2010 Nanotechnology 21 385101

20. André S Ferlauto – ferlauto@fisica.ufmg.br CNT-Oligonucleotides as transfection agent for fungi cells Patent recently deposited

21. André S Ferlauto – ferlauto@fisica.ufmg.br In-vivo experiments A - CONTROL B- CNT SOLUTION C- CNT + ANTISENSE D- CNT + SENSE

22. André S Ferlauto – ferlauto@fisica.ufmg.br First Brazilian Industrial Production Plant of MWNT High purity and perfection Low polydispersivity in length and diameter Range: 1 – 6 Kg/h

23. André S Ferlauto – ferlauto@fisica.ufmg.br Thanks to: Prof. Sumio Iijima