1. Medical Robotics Lab @ UH MRI-guided Robotic Interventions and Surgeries This technology was supported by the NSF award CNS-0932272 entitled “Multimodal Image-guided Robot-Assisted Surgeries (MIROS)” Image While You Operate for improved patient outcome and cost-effectiveness

2. Medical Robotics Lab @ UH Real-time MRI Guidance Image While You Operate Continuous visualization of the tool and the tissue for on-the-fly adjustment of the tool path Continuous monitoring of the procedure for optimal delivery of therapy (e.g. laser or cryo-ablations) No X-ray radiation (vs. fluoroscopy & CT) Superb contrast and image quality (vs. fluoroscopy & ultrasound) Improved Patient Outcome Accurate, Safer and Faster However … Limited Clinical Use …

3. Medical Robotics Lab @ UH Cost The Problem Technology Increased Duration No “true” Real-time Limited Access to Patient Current Practice MRI Robots General Solution Expensive & limited apps Limited Patient volume Access to Patient & Real-time Guidance Real-time Guidance Faster Accurate Safer Improved Patient Outcome

4. Medical Robotics Lab @ UH Our Solution Expensive Technology Limited Patient volume MR Compatible Robotics Real-time Guidance One basic system: Scalable & adaptable for a wide range of procedures and virtually any part of the patient’s body Low-cost technology of foundational building blocks

5. Medical Robotics Lab @ UH The MIROS-CPS The MIROS modular technology addresses those challenges, while creating multiple lines of products:  The novel “solid-fluid transmission” (SFT) actuation  A simple, scalable and modular SFT-actuated robot adaptable for use at different anatomies  Novel real-time MRI methods  Control software that uses real-time MRI  Haptic interfacing  Seamless integration

6. Medical Robotics Lab @ UH Our Solution vs. The Competition  Cost-effective (& independent from non-US technology)  Scalable and adaptable for procedures to virtually any area - Widest range of procedures & volume of patients - Larger market base – operators Abdomen & thorax Breast Brain Biopsies Tumor Ablations (laser/Cryo/RF) Placement of Brachytherapy Seeds Placement of Deep Brain Stimulators Localized delivery of drugs … Interventional radiologists Cancer specialists Urologists Neurosurgeons Pain-management specialists Cardiothoracic surgeons

7. Medical Robotics Lab @ UH Market (I) Interventional MRI (million procedures/year) All modalities (million procedures/year) Interventional MRI ($M) Image Guided Surgical procedures $1.89 billion (2012) Compound annual growth rate (CAGR) = 5.7% MRI 10% of global market CAGR = 3.2% WW MRI scanners 20,000 Expected growth 2-5% annual

8. Medical Robotics Lab @ UH Market (II) interventions IGI MRI interventions IGI MRI The MIROS market opportunity can be equivalent to the US and eventually the WW market opportunity Neurologic Interventions US Market Opportunity > $16 billion Parkinson’s DBS sub-segment - $1.1 billion Epilepsy Focal Ablation sub-segment - $1.8 billion Breast cancer US market Opportunity > $835M CURRENTMIROS

9. Medical Robotics Lab @ UH How: A Pipeline of Products  Common building blocks (hardware & software)  Scalable, adaptable & upgradable platform Building Blocks SFT Actuation Robot MR Methods Software Cardiothoracic Basic system Neuro Abdominal Breast Prostate Disposables Spine EXIT STRATEGIES Acquisition by one or more of the existing MRI scanner OEM (e.g. GE, Philips, Siemens) or MRI accessory (e.g. Medtronic, Boston Scientific, MRI Interventions) companies The venture continues operation and becomes a supplier to one or more existing MRI scanner OEM or MRI accessory companies

10. Medical Robotics Lab @ UH The Team Dept. of Computer Science, University of Houston Nikolaos V. Tsekos, PhD: MRI methods, MR-compatible robotics Nick von Sternberg, PhD: MR compatible robotics Clinical Collaborations: Methodist Hospital at Houston: Cardiothoracic Interventions MD Anderson Cancer Center: Breast Cancer & Prostate Cancer Business Collaborations: Bauer College of Business; University of Houston - MBA program Wolff Center for Entrepreneurship, University of Houston

11. Medical Robotics Lab @ UH NSF Award CNS-0932272 THANK YOU! MIROS: Image While You Operate for improved patient outcome and cost-effectiveness