1. Center for Stem Cell Biology & Regenerative Medicine Faculty meeting 08/01/11

2. Agenda Maryland Stem Cell Research Funding Summary – Dan Gincel, Maryland MSCRF/TEDCO Stem Cell Consortium Update – James Goolsby, Paragon Bioservices – Mohan Vemuri and Mark Powers, Life Technologies Overview of working groups – Curt Civin – Sarah Netzel-Arnett Technology Updates – Bruce Yu – Scott Devine Brief Presentations by three 2011 MSCRF Recipients – Maria Nurminskaya – Paul Yarowski – Feyruz Rassool

3. Maryland Stem Cell Research Funding Dan Gincel, PhD (Director, MSCRF/TEDCO, State of Maryland)

4. Stem Cell Center Mission Develop and support a highly collaborative and interdisciplinary environment that promotes stem cell research Encourage translation of discoveries into innovative and beneficial clinical applications that enhance the diagnosis, treatment and prevention of human diseases Establish synergistic collaborations among academia, business and federal laboratories located in Maryland

5. Stem Cell Consortium Services: Paragon Bioservices, BioPark – James Goolsby, PhD Education: Life Technologies – Mohan Vemuri, PhD – Mark Powers, PhD

6. Technologies on Campus Bruce Yu, PhD, Associate Professor at the Fischell Department of Bioengineering (UMCP) and School of Pharmacy (UMB) – byu@rx.umaryland.edu byu@rx.umaryland.edu Scott Devine, PhD, Associate Professor, Dept. of Medicine (Endocrinology), Institute for Genome Sciences – sdevine@som.umaryland.edu sdevine@som.umaryland.edu

7. Current Working Groups Intestinal stem cells Cardiovascular stem cells Neural stem cells Hematopoietic and cancer stem cells Skeletal (Muscle, Cartilage, Fat and Bone) stem cells iPS development

8. Group Members

9. Goals of Working Groups Develop collaborative research teams Promote interactions of basic researchers in translational and clinical projects Generate successful research projects and funding proposals by providing opportunities to present and discuss research findings and experimental proposals among a multidisciplinary team of colleagues

10. Expectations & Deadlines Assign coordinator Initial Meeting – end of August/ early Sept. Group Proposal Update at Fall Faculty meeting Mid-November MSCRF LOI deadline Mock reviews (December) January MSCRF Deadline

11. 2011 MSCRF Recipients Investigator Initiated – Rassool, Feyrus, “Efficacy of remodeling the DNA damage response in induced pluripotent stem cells engineered by different methods” Exploratory – Chen, Xiaochun, “MicroRNA Regulators of ex vivo Human Hematopoietic Stem Cell Expansion” – Du, Shao Jun, “Reprogramming of satellite cells and human mesenchymal stem cells for muscle repair”

12. 2011 MSCRF Recipients Exploratory cont’d – Yarowski, Paul, “Stem cell therapy for traumatic brain injury” Post doctoral Fellowship – Shanmugasundaram, Shobana, “Optimization of the 3D PLLA fiber scaffolds for osteogenic differentiation in stem cells”

13. Next Steps Send MSCRF Specific aims and reviewer comments (pinksheets) to Wendy Sanders Hold working group meetings Fall Stem Cell Center faculty meeting Any questions? – Miek Segers, – Tami Kingsbury, or – Curt Civin