1. Date of download: 5/28/2016 From: Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis Ann Intern Med. 1993;119(4):312-323. doi:10.7326/0003-4819-119-4-199308150-00011 Natural history of chronic hepatitis B acquired in childhood.[19]The initial phase of immune tolerance is followed by the phase of immune clearance of hepatitis B virus (HBV) and finally the cessation of HBV replication. The transition from the replicative to the nonreplicative phase may be rapid and smooth () or prolonged and fluctuating ( ). CPH = chronic persistent hepatitis; NSRH = nonspecific reactive hepatitis; CLH = chronic lobular hepatitis; CAH = chronic active hepatitis; HCC = hepatocellular carcinoma. From Lok and Lai, with permission. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/28/2016 From: Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis Ann Intern Med. 1993;119(4):312-323. doi:10.7326/0003-4819-119-4-199308150-00011 Randomized controlled trials of -interferon treatment for patients with chronic hepatitis B infection and hepatitis B e antigen.leftrightThe pooled and individual differences in proportions and their 95% CIs are shown for loss of hepatitis B surface antigen (HBsAg) ( ) and loss of hepatitis B e antigen (HBeAg) ( ). Values greater than 0 indicate a beneficial treatment effect. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/28/2016 From: Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis Ann Intern Med. 1993;119(4):312-323. doi:10.7326/0003-4819-119-4-199308150-00011 The effect of high-dose compared with low-dose interferon therapy in patients with chronic hepatitis B and hepatitis B e antigen.leftright22The pooled and individual differences in proportions and their 95% CIs are shown for loss of hepatitis B surface antigen (HBsAg) ( ) and loss of hepatitis B e antigen (HBeAg) ( ) for studies that randomized patients to different doses of interferon. A high dose was arbitrarily defined as greater than 15 MU/m per week (> 5 MU/m thrice weekly). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/28/2016 From: Effect of Alpha-Interferon Treatment in Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B: A Meta-Analysis Ann Intern Med. 1993;119(4):312-323. doi:10.7326/0003-4819-119-4-199308150-00011 Sensitivity analyses by quality scores.leftrightThe effect of quality scores on the pooled confidence intervals is shown for loss of hepatitis B surface antigen (HBsAg) ( ) and loss of hepatitis B e antigen (HBeAg) ( ). The trials of lower quality were sequentially eliminated. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians