1. Thyroiditis Dr. Gehan Mohamed

2. Types of thyroiditis Hashimoto ’ s thyroiditis Painless postpartum thyroiditis Painless sporadic thyroiditis Painful subacute thyroiditis Suppurative thyroiditis Drug-induced thyroiditis Riedel ’ s thyroiditis

3. Thyroiditis – Classification

4. 1- Hashimoto ’ s thyroiditis Hashimoto’s thyroiditis is the most common type of thyroiditis. It is characterized by the presence of high serum thyroid antibody concentrations and goiter. A firm, bumpy, symmetric, painless goiter is frequently the initial finding in Hashimoto’s thyroiditis. About 10 percent of patients with chronic autoimmune hypothyroidism have atrophic thyroid glands (rather than goiter), as atrophy represent the final stage of thyroid failure in Hashimoto’s thyroiditis.

5. Genetic susceptibility for Hashimoto ’ s thyroiditis Association of Hashimoto’s thyroiditis and painless postpartum thyroiditis with HLA- DR3, HLA-DR4, and HLA-DR5 has been reported in white persons.

6. Mechanisms of autoimmune thyroid destruction The mechanism for autoimmune destruction of the thyroid probably involves: a- cellular immunity in form of Lymphocytic infiltration of the thyroid gland by equal numbers of B cells and cytotoxic T cells. B- humoral immunity in the form of autoantibodies attacking the thyroid...

7. Normal thyroid Hashimotos’ thyroiditis: showing lymphoid follicles with germinal center,eosinophilic hurthle cells lining the thyroid follicles

8. Complications of Hashimoto’s thyroiditis. 1- Hypothyroidism is very common Among patients with Hashimoto’s thyroiditis specially if they are smokers a finding that may be related to the presence of thiocyanates in cigarette smoke. 2- lymphoma. 3-thyroid carcinoma.

9. 2- Painless postpartum thyroiditis There is lymphocytic infiltration of the thyroid within the first few months after delivery. The disease is most common in women who have : a- high serum thyroid peroxidase antibody concentrations, thyroglobulin antibodies during the first trimester of pregnancy or immediately after delivery. b- those with other autoimmune disorders, such as type 1 diabetes mellitus. c- those with a family history of autoimmune thyroid disease.

10. classic triphasic thyroid hormone pattern develop : a- Thyrotoxicosis typically begins one to six months after delivery and lasts for one to two months. b- hypothyroid phase starting four to eight months after delivery and lasting four to six months. c- Eighty percent of women recover normal thyroid function within a year, however, permanent hypothyroidism can develop.

11. 3- Painless sporadic thyroiditis Painless postpartum thyroiditis and painless sporadic thyroiditis are indistinguishable except by the relation of the former to pregnancy. The clinical course is similar to that of painless postpartum thyroiditis.

12. 4- Suppurative thyroiditis Suppurative thyroiditis is usually caused by bacterial infection, but fungal, mycobacterial, or parasitic infections may also occur as the cause. The thyroid is resistant to infection, because of its encapsulation, high iodide content, rich blood supply, and extensive lymphatic drainage, and suppurative thyroiditis is therefore rare.

13. It is most likely to occur in patients with : a-preexisting thyroid disease (thyroid cancer, Hashimoto’s thyroiditis, or multinodular goiter) b- congenital anomalies such as a pyriform sinus, fistula (the most common source of infection in children) c- who are immunosuppressed, elderly, or debilitated; it is particularly likely to occur in patients with the acquired immunodeficiency syndrome (AIDS), in whom Pneumocystis carinii and other opportunistic thyroid infections have been reported.

14. Patients with suppurative bacterial thyroiditis are usually acutely ill with fever, dysphagia, dysphonia, anterior neck pain and erythema, and a tender thyroid mass. Symptoms may be preceded by an acute upper respiratory infection.

15. Thyroid function is generally normal in patients with suppurative thyroiditis, but both thyrotoxicosis and hypothyroidism have been reported. Leukocyte counts and erythrocyte sedimentation rates are elevated. Suppurative areas appear “cold” on radioactive- iodine scanning. Fine-needle aspiration biopsy with Gram’s staining and culture is the diagnostic test of choice. The therapy for suppurative thyroiditis consists of appropriate antibiotics and drainage of any abscess. The disease may prove fatal if diagnosis and treatment are delayed.

16. 5-Drug-induced Thyroiditis Many medications can alter thyroid function or the results of thyroid-function tests. However, only a few are known to provoke autoimmune or destructive inflammatory thyroiditis. (Amiodarone; Lithium; Interferon Alfa and Interleukin-2)

17. 6- Riedel ’ s Thyroiditis Riedel’s thyroiditis, a local manifestation of a systemic fibrotic process, is a progressive fibrosis of the thyroid gland that may extend to surrounding tissues. High serum thyroid antibody concentrations are present in up to 67 percent of patients, but it is unclear whether the antibodies are a cause or effect of the fibrotic thyroid destruction.

18. Patients with Riedel’s thyroiditis present with a rock-hard, fixed, painless goiter. They may have symptoms due to tracheal or esophageal compression or hypoparathyroidism due to extension of the fibrosis into adjacent parathyroid tissue. Most patients are euthyroid at presentation but become hypothyroid once replacement of normal thyroid tissue is nearly complete.

19. 7-Subacute (de Quervain’s) Thyroiditis = granulomatous thyroiditis 5:1 female predominance Age of onset 20-60y Prodrome (myalgias, fever, pharyngitis) Seasonal variation (?correlation with enterovirus?) Fever/severe neck pain 50-60% develop thyrotoxicosis 2-9% with recurrent disease Normal thyroid function returns in 95% 5% residual hypothyroidism Usually low to absent titer of anti-TPO immunoglobulins

20. Diagnostic evaluation Laboratory tests: ESR*, CRP TSH* T3, T4 (T4:T3 ratio <20) Free T4* Thyroid antibodies (anti-TPO, anti-thyroglobulin, TSI) TBG (thyroxine binding globulin)

21. Radioactive Iodine Uptake Scans Normal uptake in 30yo woman with postpartum painless thyroiditis Increased uptake in 52yo woman with Grave’s disease Decreased uptake in 42yo woman with subacute granulomatous thyrdoitis

22. Granulomatous (subacute )thyroiditis

23. Subacute thyroiditis – pathology Multinucleated giant cell

24. Points to take home Subacute granulomatous thyroiditis is usually self-limited disease Hyper, normo, hypothyroid phases over course of 6-9 months Hyperthyroid work-up should include TSH, free T4, RAIU at minimum

25. Hormonal changes associating thyroiditis A- Transient Thyrotoxicosis associating thyroiditis: In painless sporadic thyroiditis, painless postpartum thyroiditis, and painful subacute thyroiditis, inflammatory destruction of the thyroid may lead to transient thyrotoxicosis as preformed thyroid hormones are released from the damaged gland. B- The hypothyroid phase of thyroiditis results from the gradual depletion of stored thyroid hormones. Although chronic hypothyroidism is most closely associated with Hashimoto’s thyroiditis, all types of thyroiditis may progress to permanent hypothyroidism.