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Human Genetics Integrative Bioinformatics using Cytoscape (and R2)

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Presentation on theme: "Human Genetics Integrative Bioinformatics using Cytoscape (and R2)"— Presentation transcript:

1 Human Genetics Integrative Bioinformatics using Cytoscape (and R2)

2 Human Genetics External data sources Statistical analysis Perl module AMC Plugin Canonical paths DB Patient data GEO arrays Wet-lab data Algorithms Data input interface Array data: Tumor and time series R2-array analysis interface Cytoscape interface

3 Human Genetics

4 Tf (green) and partners (red)

5 Human Genetics Filtering

6 Human Genetics Filtering

7 Human Genetics Coloring, layout

8 Human Genetics Tf and partners

9 Human Genetics Availability R2 –Available shortly through http://humangenetics-amc.nl –Keep yourself posted on http://groups.google.com/group/r2-announce

10 Human Genetics Acknowledgements Department of Human Genetics - Academic Medical Center Piet Molenaar Jan Koster Richard Volckmann Rogier Versteeg NBIC-Biorange programme Cytoscape community Cytoscape Consortium –UC San Diego –Institute for Systems Biology –Memorial Sloan-Kettering Cancer Center –Agilent Technologies –Unilever –UC San Francisco –University of Toronto –Institut Pasteur Any questions later on: p.molenaar@amc.uva.nl

11 Human Genetics

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16 Timeseries in R2

17 Human Genetics

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25 Not only multiplo

26 Human Genetics

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31 Network inference: TF and GO analysis

32 Human Genetics

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