2. Blood Vessels Blood is carried in a closed system of vessels that begins and ends at the heart The three major types of vessels are arteries, capillaries, and veins Arteries carry blood away from the heart, veins carry blood toward the heart Capillaries contact tissue cells and directly serve cellular needs

3. Tunica interna (tunica intima) Endothelial layer that lines the lumen of all vessels In vessels larger than 1 mm, a subendothelial connective tissue basement membrane is present Tunica media Smooth muscle and elastic fiber layer, regulated by sympathetic nervous system Controls vasoconstriction/vasodilation of vessels Tunics

4. Tunica externa (tunica adventitia) Collagen fibers that protect and reinforce vessels Larger vessels contain vasa vasorum Tunics

5. Blood Vessel Structure simple squamous epithelium smooth muscle tissue connective tissue

6. Figure 19.1b Tunica media (smooth muscle and elastic fibers) Tunica externa (collagen fibers) Lumen Artery Lumen Vein Internal elastic lamina External elastic lamina Valve (b) Endothelial cells Basement membrane Capillary network Capillary Tunica intima Endothelium Subendothelial layer

7. Artery vein

8. Arteries 1. Carry blood away from the heart. 2. Thick-walled to withstand hydrostatic pressure of the blood during ventricular systole. 3. Blood pressure pushes blood through the vessel

9. Arteries Elastic Muscular Arteriole

10. Elastic (Conducting) Arteries Thick-walled arteries near the heart; the aorta and its major branches Large lumen allow low-resistance conduction of blood Contain elastin in all three tunics Withstand and smooth out large blood pressure fluctuations Allow blood to flow fairly continuously through the body

11. Muscular (Distributing) Arteries and Arterioles Muscular arteries – distal to elastic arteries; deliver blood to body organs Have thick tunica media with more smooth muscle and less elastic tissue Active in vasoconstriction Arterioles – smallest arteries; lead to capillary beds Control flow into capillary beds via vasodilation and constriction

12. Fig.21.02 Pressure reservoir function of elastic arteries

13. Fig.21.02 Aneurysm

14. Veins Carry blood to the heart. Thinner-walled than arteries. Possess one-way valves that prevent backwards flow of blood. Blood flow due to body movements, not from blood pressure.

15. One-Way Valves in Veins open valve closed valve

16. Varicose Veins

18. Capillaries One cell thick, endothilium Function: Diffusion Filtration Transcytosis

19. CO 2 O2O2 Diffusion

20. Filtration

21. Basement membrane Endothelial fenestration (pore) Intercellular cleft Pinocytotic vesicles Caveolae 4 Transport via vesicles or caveolae (large substances) 3 Movement through fenestrations (water-soluble substances) 2 Movement through intercellular clefts (water-soluble substances) 1 Diffusion through membrane (lipid-soluble substances) Lumen Transcytosis

22. Capillaries are the smallest blood vessels Walls consisting of a thin tunica interna, one cell thick Allow only a single RBC to pass at a time Pericytes on the outer surface stabilize their walls There are three structural types of capillaries: continuous, fenestrated, and sinusoids Capillaries

23. Continuous Capillaries Continuous capillaries are abundant in the skin and muscles, and have: Endothelial cells that provide an uninterrupted lining Adjacent cells that are held together with tight junctions Intercellular clefts of unjoined membranes that allow the passage of fluids

24. Continuous capillaries of the brain: Have tight junctions completely around the endothelium Constitute the blood-brain barrier Continuous Capillaries

25. Figure 19.3a

26. Fenestrated Capillaries Found wherever active capillary absorption or filtrate formation occurs (e.g., small intestines, endocrine glands, and kidneys) b b Characterized by: An endothelium riddled with pores (fenestrations) Greater permeability to solutes and fluids than other capillaries

27. Fenestrated Capillaries Figure 19.3b

28. Sinusoids Highly modified, leaky, fenestrated capillaries with large lumens Found in the liver, bone marrow, lymphoid tissue, and in some endocrine organs Allow large molecules (proteins and blood cells) to pass between the blood and surrounding tissues Blood flows sluggishly, allowing for modification in various ways

29. Sinusoids Figure 19.3c

30. Capillary Beds A microcirculation of interwoven networks of capillaries, consisting of: Vascular shunts – metarteriole– thoroughfare channel connecting an arteriole directly with a postcapillary venule True capillaries – 10 to 100 per capillary bed, capillaries branch off the metarteriole and return to the thoroughfare channel at the distal end of the bed

32. Figure 19.4 (b) Sphincters closed —blood flows through metarteriole thoroughfare channel and bypasses true capillaries. Terminal arteriole Postcapillary venule

33. venule capillaries arteriole

34. Blood pressure (BP) Force per unit area exerted on the wall of a blood vessel by the blood – –Expressed in mm Hg – –Measured as systemic arterial BP in large arteries near the heart The pressure gradient provides the driving force that keeps blood moving from higher to lower pressure areas

35. Resistance (peripheral resistance) Opposition to flowOpposition to flow Measure of the amount of friction blood encountersMeasure of the amount of friction blood encounters Generally encountered in the peripheral systemic circulationGenerally encountered in the peripheral systemic circulation Three important sources of resistance Blood viscosityBlood viscosity Total blood vessel lengthTotal blood vessel length Blood vessel diameterBlood vessel diameter

36. Systemic Blood Pressure   The pumping action of the heart generates blood flow   Pressure results when flow is opposed by resistance   Systemic pressure Is highest in the aorta Declines throughout the pathway Is 0 mm Hg in the right atrium   The steepest drop occurs in arterioles

37. Figure 19.6 Systolic pressure Mean pressure Diastolic pressure

38. Resistance Factors that remain relatively constant: Blood viscosity – –The “stickiness” of the blood due to formed elements and plasma proteins Blood vessel length – –The longer the vessel, the greater the resistance encountered

39. Resistance Frequent changes alter peripheral resistance Varies inversely with the fourth power of vessel radius E.g., if the radius is doubled, the resistance is 1/16 as much

40. Resistance Small-diameter arterioles are the major determinants of peripheral resistance Abrupt changes in diameter or fatty plaques from atherosclerosis dramatically increase resistance Disrupt laminar flow and cause turbulence

41. Mm Hg 120- 80- ArteryArterioleCapillaryVenuleVein

42. Baroreceptors

43. Short-Term Hormonal Control Vasoconstrictors: Norepinephrine and epinephrine Angiotensin II ADH Vasodilators: ANP (atrial natriutic peptide) PTH NO

45. Sphygmomanometer Used to estimate pressure

46. Measuring Blood Pressure

47. 120/80 is good Blood Pressure

48. brachial carotid Superficial Pulse Points- arteries, not veins radial femoral Temporal artery Facial artery Common carotid artery Brachial artery Radial artery Femoral artery Popliteal artery Posterior tibial artery Dorsal pedis artery 60 beats/minute popliteal facial temporal Posterior tibial Dorsal pedis

49. Homeostatic Imbalances Tachycardia: abnormally fast heart rate (>100 bpm) If persistent, may lead to fibrillation Bradycardia: heart rate slower than 60 bpm May result in grossly inadequate blood circulation May be desirable result of endurance training

50. Circulatory Shock Any condition in which Blood vessels are inadequately filled Blood cannot circulate normally Results in inadequate blood flow to meet tissue needs

51. Circulatory Shock Hypovolemic shock: results from large-scale blood loss Vascular shock: results from extreme vasodilation and decreased peripheral resistance Cardiogenic shock: results when an inefficient heart cannot sustain adequate circulation

52. Three Types of Circulation 1. Pulmonary 2. Systemic 3. Coronary

53. Figure 19.17b Pulmonary Circulation

54. Figure 19.17b Pulmonary Circulation

55. Systemic Circulation

56. Figure 19.18 Systemic Circulation

57. Coronary Circulation Marginal Artery Right coronary artery Great Cardiac Vein Anterior interventricular artery Circumflex artery Left coronary artery

58. Coronary Circulation Inferior vena cava Middle cardiac Veins Posterior interventricular artery Great cardiac vein Coronary sinus (b) The major cardiac veins Superior vena cava Posterior vein

60. Fig.21.18b

61. Fig.21.20 Brachiocephalic Right subclavian Right Common Carotid Left Common Carotid Left Subclavian

62. Fig.21.20

64. Fig.21.22a

65. Fig.21.23

67. Fig.21.25

68. Fig.21.26

69. Fig.21.27

70. Fig.21.28

72. Hepatic Portal Circulation Left Gastric Vein Splenic Vein Inferior Mesentaric Vein Renal Vein Superior Mesentaric Vein Right Gastropiplore Vein Hepatic Portal Hepatic Vein Inferior Vena cava

73. liver Inferior vena cava Hepatic veins Abdominal aorta Proper hepatic artery Hepatic portal vein Splenic vein Superior mesenteric vein Tributaries from portions of stomach. pancreas & lg intestine Tributaries from sm intestine & portions of stomach, lg intestine & pancreas

74. Fetal Circulation Placenta - site where exchange of materials between fetus and mother occur Umbilical arteries (2) - carry fetal blood high in CO 2 / low in O 2 to the placenta Umbilical vein - returns oxygenated blood from the placenta to the fetus

75. Fetal Circulation Ductus venosus - allows blood to bypass the liver Foramen ovale - opening in interatrial septum allowing blood to bypass the lungs Blood flows from r.atrium ->l.atrium Ductus arteriosus - vessel connecting pulmonary artery to the aorta

76. Fetal circulation and changes at birth

77. INQUIRY 1.Sedentary people with elevated triglyceride levels who continue to eat fatty foods are likely to have a high level of _____. 2.Which vessels have valves? 3.Which vessel is the thickest walled? 4.What type of blood vessels carry blood away from the heart? 5.What happens when blood is pumped into the thin- walled vessels of the lungs? 6.Which blood vessel delivers blood to the brain? 7.Which blood vessel delivers blood to the liver? 8.The distinctive Korotkoff sounds heard when taking blood pressure are produced by ____.