2. What are AGEs and what causes them? How do we measure AGEs? How do we manage AGEs?

3. What are AGEs and what causes them?

5. AGEs [ADVANCED GLYCATION END PRODUCTS]

6. Schleicher et al. J. Clin. Invest. 1997. 99:457–468. AGEs increase in organs as we grow older

7. AGE = “Life Marker”

8. AGEs increase in skin (∆) and in cartilage (●) as we grow older Schleicher et al. J. Clin. Invest. 1997. 99:457–468.

9. Healthy Weight Kidney Health Immune Function Heart Health Healthy Joints Blood Sugar Levels Arterial Health Circulatory Function Brain Health Eye Health Skin Health AGEs

10. Aging is defined as: AGEs & Aging “The decline of anatomical integrity and function across multiple organ systems and a reduced ability to respond to stress” Semba et al. J Gerontol A Biol Sci Med Sci. 2010 September; 65A(9): 963–975

11. AGEs form when excess AGEs SUGAR & PROTEIN bind together.

12. AGEs bind to AGEs HEALTHY TISSUES and damage them

13. AGEs form INSIDE your body

14. AGEs form OUTSIDE your body

15. AGEs cannot be avoided… but they can be MINIMIZED

16. AGE Accelerators Stress Disease Injury Insufficient Sleep Poor Lifestyle Choices Sun Damage Genetics

17. How do we measure AGEs?

18. AGE Fluorescence

19. Yue et al. 2011. Diabet. Med. 28, 818–823 Skin AGEs & Aging

21. Blood Sample Urinalysis Tissue Biopsy

22. Simple

23. Inventor of the TrūAge Scanner Dr. Andries J. Smit (MD, PhD) Faculty of Medical Sciences, Internal Medicine, University Medical Center Groningen. Authored or co-authored over 200 scientific publications. Trained in internal medicine.

25. History of Scanner Development 1995: Dr. Smit and his co-workers made a coincidental finding of increased autofluorescence of the skin in diabetes patients while performing a clinical trial on blood vessel health.

26. History of Scanner Development 1996: Dr. Smit and Dr. Graaff developed prototypes to measure skin autofluorescence in humans.

27. History of Scanner Development 1998: First clinical studies in diabetes and renal failure were started with an advanced prototype of the AGE Reader at the University Hospital in Groningen, Netherlands.

28. History of Scanner Development 2000: Initiated the first large scale follow-up study.

29. History of Scanner Development 2003: Dr. Smit and Dr. Graaff founded Diagnoptics in the Netherlands.

30. History of Scanner Development 2011: Diagnoptics partners with Morinda to develop the TrūAge Scanner.

31. 100 Clinical Studies

34. How do we manage AGEs?

35. Uncle “Teeny” Age: 102 TrūAge: 79

36. Uncle “Teeny” Age: 102 TrūAge: 79 Feels: 55

37. Water

38. GRILLED CARMELIZED CRISPY ROASTED FRIED CHAR-BROILED

39. 81.2 79.1 79.0 Okinawa Hong Kong Sweden Mortality Rates 79.9 Japan

40. Hong Kong Okinawa Sweden

41. + Heat + Sugar + Fat + Protein High AGEs

42. + Water + Acid Low AGEs

43. Roasted 450°F for 45 minutes = 5,975 Poached In liquid for 1 hour = 990

44. Step 1: Healthy Lifestyle

45. Healthy Lifestyle

46. Step 2: Prevention

48. Step 3: Renew

50. Step 2: Prevention Step 1: Healthy Lifestyle Step 3: Renew

51. IRIDOIDS

52. The statements within this presentation have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

53. DAA (Iridoid) Increase Antioxidant Enzyme

54. Effect of Max on Blood Sugar

55. Effect of Max on AGE Score in Human Clinical Trial Influence of TrūAge Max on AGE Score

56. MAXimum Benefit MAXimum Value

57. Eat less sugar Stop smoking & drinking alcohol Reduce coffee intake Get 8 hours of sleep every night Avoid harmful UVA & UVB rays WHAT ELSE CAN REDUCE AGEs?

58. KNOW YOUR NUMBERS CHANGE YOUR NUMBERS