1. HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials Dr Daniel I Swerdlow, PhD, Dr David Preiss, MD, Karoline B Kuchenbaecker, MSc, Michael V Holmes, PhD, Jorgen E L Engmann, MSc, Tina Shah, PhD, Reecha Sofat, MD, Stefan Stender, MD, Paul C D Johnson, PhD, Robert A Scott, PhD, Maarten Leusink, MSc, Niek Verweij, MD, Stephen J Sharp, MSc, Yiran Guo, PhD, Claudia Giambartolomei, MSc, Christina Chung, MSc, Anne Peasey, PhD, Antoinette Amuzu, MSc, KaWah Li, MSc, Jutta Palmen, MSc, Philip Howard, MSc, Jackie A Cooper, MSc, Fotios Drenos, PhD, Yun R Li, BSc, Prof Gordon Lowe, DSc, John Gallacher, PhD, Marlene C W Stewart, PhD, Ioanna Tzoulaki, PhD, Sarah G Buxbaum, PhD, Daphne L van der A, PhD, Nita G Forouhi, MRCP, N Charlotte Onland-Moret, PhD, Prof Yvonne T van der Schouw, PhD, Renate B Schnabel, MD, Jaroslav A Hubacek, PhD, Ruzena Kubinova, MD, Migle Baceviciene, MD, Prof Abdonas Tamosiunas, MD, Prof Andrzej Pajak, MD, Romanvan Topor-Madry, MD, Urszula Stepaniak, PhD, Prof Sofia Malyutina, MD, Damiano Baldassarre, PhD, Bengt Sennblad, PhD, Prof Elena Tremoli, PhD, Prof Ulf de Faire, MD, Fabrizio Veglia, PhD, Prof Ian Ford, PhD, Prof J Wouter Jukema, MD, Prof Rudi G J Westendorp, MD, Gert Jan de Borst, MD, Pim A de Jong, MD, Prof Ale Algra, MD, Wilko Spiering, MD, Anke H Maitland- van der Zee, PhD, Olaf H Klungel, PharmD, Prof Anthonius de Boer, MD, Prof Pieter A Doevendans, MD, Prof Charles B Eaton, MD, Prof Jennifer G Robinson, MD, David Duggan, PhD, Prof John Kjekshus, MD, John R Downs, MD, Antonio M Gotto, MD, Anthony C Keech, MD, Roberto Marchioli, MD, Gianni Tognoni, MD, Prof Peter S Sever, FRCP, Prof Neil R Poulter, FMedSci, David D Waters, MD, Terje R Pedersen, MD, Pierre Amarenco, MD, Haruo Nakamura, MD, Prof John J V McMurray, MD, James D Lewsey, PhD, Daniel I Chasman, PhD, Paul M Ridker, MD, Prof Aldo P Maggioni, MD, Prof Luigi Tavazzi, MD, Prof Kausik K Ray, MD, Sreenivasa Rao Kondapally Seshasai, MD, Prof JoAnn E Manson, MD, Jackie F Price, MD, Prof Peter H Whincup, MD, Prof Richard W Morris, PhD, Prof Debbie A Lawlor, PhD, Prof George Davey Smith, MD, Prof Yoav Ben-Shlomo, PhD, Prof Pamela J Schreiner, PhD, Prof Myriam Fornage, PhD, Prof David S Siscovick, MD, Mary Cushman, MD, Meena Kumari, PhD, Prof Nick J Wareham, FRCP, W M Monique Verschuren, PhD, Prof Susan Redline, MD, Sanjay R Patel, MD, Prof John C Whittaker, PhD, Prof Anders Hamsten, MD, Joseph A Delaney, PhD, Caroline Dale, PhD, Tom R Gaunt, PhD, Andrew Wong, PhD, Prof Diana Kuh, PhD, Prof Rebecca Hardy, PhD, Sekar Kathiresan, MD, Berta A Castillo, PhD, Prof Pim van der Harst, MD, Prof Eric J Brunner, PhD, Prof Anne Tybjaerg-Hansen, MD,, Prof Michael G Marmot, FRCP, Ronald M Krauss, MD, Prof Michael Tsai, MD, Prof Josef Coresh, MD, Ronald C Hoogeveen, PhD, Prof Bruce M Psaty, MD, Leslie A Lange, PhD, Prof Hakon Hakonarson, MD, Frank Dudbridge, PhD, Prof Steve E Humphries, FAMS, Prof Philippa J Talmud, DSc, Prof Mika Kivimäki, PhD, Nicholas J Timpson, PhD, Claudia Langenberg, MD, Folkert W Asselbergs, MD, Prof Mikhail Voevoda, MD, Prof Martin Bobak, MD, Hynek Pikhart, PhD, Prof James G Wilson, MD, Prof Alex P Reiner, MD, Brendan J Keating, PhD, Prof Aroon D Hingorani, FRCP, Prof Naveed Sattar, FRCP The Lancet Volume 385, Issue 9965, Pages 351-361 (January 2015) DOI: 10.1016/S0140-6736(14)61183-1 Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY Terms and Conditions Terms and Conditions

2. Figure 1 The Lancet 2015 385, 351-361DOI: (10.1016/S0140-6736(14)61183-1) Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY Terms and Conditions Terms and Conditions

3. Figure 2 The Lancet 2015 385, 351-361DOI: (10.1016/S0140-6736(14)61183-1) Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY Terms and Conditions Terms and Conditions

4. Figure 3 The Lancet 2015 385, 351-361DOI: (10.1016/S0140-6736(14)61183-1) Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY Terms and Conditions Terms and Conditions

5. Figure 4 The Lancet 2015 385, 351-361DOI: (10.1016/S0140-6736(14)61183-1) Copyright © 2015 Swerdlow et al. Open Access article distributed under the terms of CC BY Terms and Conditions Terms and Conditions