1. The Epidemiology of Idiopathic Pulmonary Fibrosis Vidya Navaratnam University of Nottingham

2. What is IPF? Chronic, progressive, fibrotic lung disease of unknown aetiology More common in men Average age of presentation 71 years Median survival 3 years Lots of symptoms 7 years of life lost

3. How common is IPF?

4. Textbooks in the 1990s Not a common disease Disease of middle aged people

5. Number of deaths from CFA in England and Wales

7. Summary of incidence in early 1990s StudyRate per 100,000 pyrs New Mexico3 UK death certificates2.8 UK general practice4

8. Incidence over time - update Gribbin Thorax 2006:61:980

9. Idiopathic Pulmonary Fibrosis -New

10. Primary Care Data CasesCrude incidence rates (95% CI) per 100 000 person years Rate Ratios (95%CI) Year 20001605.77 (4.95 to 6.74)1 20011796.12 (5.28 to 7.08)1.08 (0.87 to 1.33 ) 20022036.69 (5.83 to 7.68)1.20 (0.98 to 1.48 ) 20032217.14 (6.26 to 8.15)1.30 (1.06 to 1.60 ) 20042538.08 (7.14 to 9.14)1.41 (1.16 to 1.72 ) 20052608.14 (7.21 to 9.19)1.45 (1.19 to 1.77 ) 20062437.54 (6.65 to 8.55)1.35 (1.11 to 1.65 ) 20072949.05 (8.07 to 10.15)1.63 (1.34 to 1.98 ) 20082618.04 (7.12 to 9.08)1.37 (1.12 to 1.67) p for trend <0.0001

11. Hospital admissions in England

12. Incidence summary IPF deaths in England and Wales 479 in 1968 3019 in 2008 Incidence rate About 8 per 100,000 person years About 5000 new cases a year 5% increase per year

14. Trent Lung Fibrosis Study: The clot thickens

15. Thank you Richard Hubbard Andrew Fogarty Norma Thompson Tricia McKeever Gisli Jenkins Sue Ledger Kate Fleming Joe West