1. A NEW POWERFUL AND EFFECTIVE LYPOLITIC ACTIVE INGREDIENT

2. LIPOREDUX PRO FOR FORKOLIN @97% FORKOLIN @97% (from GMP production site) CLA Carnitine CLA Carnitine (Kalichem’s patented ingredient)

3. CLA CARNITINE oo COO - N+N+N+N+ CH 3

4. CLA CARNITINE COMPOSITION CLA CARNITINE L-Carnitine L-Carnitine Aminoacid (Endogenous Transporter) CLA CLA Coniugated Linoleic Acid (Blend of isomers)oo COO - N+N+N+N+ CH 3

5. L-CARNITINE THIS MEANS… Lipolitic activity! Discovered in 1905 in muscular tissues. Transports long chains of fatty acids from cytosol to the mitochondrions. There, the process continues with β oxidation  Krebs cycle  oxidative phosphorylation  …  the production of energy in the ATP form.

6. CLA’S PROPERTIES Promotes the reduction of body fat and helps thin mass development in 90 days a 20 % decrease in body fat without significant weight shift (from a recent research) Promotes the Strengthening of the lean mass (Research programme at Wisconsin University on subjects who were given CLA) Reduces the dimension of adipocytes, but does not affect their number (In a recent study conducted, with the purpose of assessing CLA’s action dynamic in relation to the lipidic metabolism.) an essential fat that:

7. CLA CARNITINE Expected SYNERGISTIC biological action in comparison to individual molecules

8. Expected SYNERGISTIC biological action Expected SYNERGISTIC biological action (in comparison to individual molecules) Sensible reduction of the body fat Lean body mass development Increased metabolic efficiency better use of the high energy molecules (lipids) leads to more fat burning during exercise

9. ADVANTAGES Immediate availability More Carnitine concentration at the deep cell level

10. FORSKOLIN

11. FORSKOLIN 97% COLEUS EXTRACT THERMOGENIC AGENT LYPOLITIC AGENT GMP Coleus forskohlii extract is produced from the root of Coleus Forskohlii with a special extraction process FROM GMP PLANT that allows a never reached, maximum purity level: 97% 97% of the active principle

12. STRUCTURE, FUNCTIONALITY AND ALTERATIONS OF THE ADIPOSE TISSUE STRUCTURE, FUNCTIONALITY AND ALTERATIONS OF THE ADIPOSE TISSUE Adipose tissue: mainly composed of two types of cells: white adipocytes brown adipocytes that have complementary functions, and are heavily vascularized by capillaries In case of an excessive accumulation of fat: 1- progressive increase of free radicals with inflammatory consequences 2- The adipose tissue becomes less reactive to common weight loss strategies

13. FORSKOLIN EFFECTS Forskolin is a labdane diterpene that activates the enzyme adenylate cyclase (a turnkey compound that initiates a cascade of important events within each cell of the body) raising of cyclic AMP levels in a variety of tissues Cyclic AMP activates many other enzymes involved in different cellular functions

14. White adypocite AFTER - Glycerol - 3 Fatty acids FORSKOLIN @97% White adypocite BEFORE Adenylate Cyclase ACTIVATION OF THE ENZYME LYPOLITIC EFFECT Cyclic AMP Temperature increase Hormonal action Fat burning increase Tryglicerides composed by: - Glycerol - 3 Fatty acids

15. FORSKOLIN EFFECTS cyclic AMP may regulate the body’s thermogenic response to food increasing the metabolic rate of the body and the utilization of fat Topical Forskolin treatment can be associated with persistent melanisation epidermal cell accumulation and increased skin thickening BODY FAT AND BODY SHAPE MANAGEMENT TANNING AND UV-PROTECTION Moreover:

16. A SAFE INGREDIENT Forskolin is widely used by oral intake in medicine to treat allergies and adverse skin conditions There are no major side effects reported in literature VERY SAFE

17. COSMETIC APPLICATIONS Reducing cellulites & fat deposition The new findings concerning the ability of Forskolin to increase the capacity of repairing the UV-induced DNA damage and to promote melanisation suggest its use in sunscreen products thus allowing multiple benefits Increasing the skin’s natural resistance to burning Increasing the natural resistance to UV light Antioxidant activity against cell membrane attack Decreasing the visible signs of photoaging Stimulation of the tanning response Re-activation of the aged skin

19. LIPOREDUX PRO FOR FORKOLIN @97% FORKOLIN @97% (from GMP production site) CLA Carnitine CLA Carnitine (Kalichem’s patented ingredient)

20. EFFICAY TEST In Vivo

21. - Test carried out by a aesthetic clinic - 30 women affected by edematous fibrosclerotic panniculopathy (EFSP) of the thigh - 15 cases were treated with Liporedux Pro For @3% in a cream; the others with comparison cream - 2 times x 4 weeks study EFFICACY TEST

22. Application: - every day in the evening -on the skin of both thighs Efficacy : judgment expressed by the volunteer as: -Good (score >80) -sufficient -low -Insufficient (score 0) Tolerability : was evaluated by professionals on the basis of parameters recorded during twelve subsequent visits; EFFICACY TEST

23. RESULTS : POSITIVE JUDGMENTS 1 – Pre-Treatment (1 Week) - only data enter - 2 – First Period (4 Weeks) 3 – Wash Out Period (4 Weeks) 4 – Second Period (4 Weeks) 5 – Follow Up (4 Weeks) Compar Cream

24. RESULTS: THIGH CIRCUMFERENCE Compar Cream

25. AVERAGE THIGH REDUCTION -2,34 cm in 17 weeks

26. CONCLUSION Liporedux Pro For has : a more significant effect on cellulite vs the comparison cream A gradual increase of Cellulite reduction during the treatment periods. no heart rate or blood pressure side effects (thus) a good tolerability of the product No side effects on the skin were observed. (local and systemic good tolerability also if used for prolonged treatments and repeated cycles)

27. LIPOREDUX PRO FOR CLA-CARNITINE + FORSKOLIN @ 97% THE IDEAL SLIMMING AGENT ABLE TO ACT ON LIPIDS (such as triglycerides) Improves the AESTHETIC ASPECT OF (ORANGE PEEL / BODY) SKIN. FOR MEN AND WOMEN NEW ANTI-CELLULITE LIPOLYTIC TONING active ingredient

28. Via Pastore 1 - 25082 Botticino Sera (Brescia) Italy Tel. +39 0302693532 - Fax. +39 0302193581 www.kalichem.it kalichem@kalichem.it