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PowerPoint Slides for Chapter 1: Heritable Material by A. Malcolm Campbell, Laurie J. Heyer, & Christopher Paradise 1.5 Is all genetic information encoded linearly in the DNA sequence? Integrating Concepts in Biology Title Page Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Biology Learning Objectives Describe the epigenetic code using methylcytosine and its effects on gene activity. Evaluate experimental design and analyze data from research on DNA as molecular information. Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Normal Bases Fig. 1.18 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Methylated Bases Fig. 1.18 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Methylated Bases Fig. 1.18 different chemical structures different physical properties Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Methylated Bases Fig. 1.18 these are NOT mutations! methylation is epigenetic change Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Thin Layer Chromatography Fig. 1.19 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Thin Layer Chromatography Fig. 1.19 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Thin Layer Chromatography Fig. 1.19 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Thin Layer Chromatography Fig. 1.19 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Thin Layer Chromatography Fig. 1.19 Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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Bases of Active vs Inactive DNA Fig. 1.20 from Naveh-Many and Cedar. 1981.
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Bases of Active vs Inactive DNA Fig. 1.20 from Naveh-Many and Cedar. 1981.
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Bases of Active vs Inactive DNA Fig. 1.20 What is the general rule about gene activity and methylation? from Naveh-Many and Cedar. 1981.
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Bases of Active vs Inactive DNA Fig. 1.20 What is the general rule about gene activity and methylation? active genes are hypomethylated inactive genes are hypermethylated from Naveh-Many and Cedar. 1981.
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Fig. 1.20 active genes are hypomethylated inactive genes are hypermethylated Cause vs Correlation from Naveh-Many and Cedar. 1981.
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Pharmacological Gene Regulation Fig. 1.21 adult monkey responsed to methylase inhibitor Can genes be regulated by epigenetic changes? modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 adult monkey responsed to methylase inhibitor fetal hemoglobin levels over time modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 fetal hemoglobin in response to methylation inhibitor modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 fetal hemoglobin in response to methylation inhibitor modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 third (higher) dose of methylation inhibitor modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 What is the consequence of higher inhibitor dose? modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 What is the consequence of higher inhibitor dose? modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 What is the consequence of higher inhibitor dose? modified from DeSimone, et al., 1982
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Pharmacological Gene Regulation Fig. 1.21 Why was this a bad idea for clinical use? modified from DeSimone, et al., 1982
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Fig. 1.21 Does this experiment show causation? Cause vs Correlation modified from DeSimone, et al., 1982
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End of Chapter 1 Exam questions drawn from: IQs Review Questions End of Chapter Look at old tests. Use this weekend to catch up. Pace will pick up from now on. First exam in 2 weeks. Copyright © 2015 by AM Campbell, LJ Heyer, CJ Paradise. All rights reserved.
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