1. Long-term prognostic value of white coat hypertension: an insight from diagnostic use of both ambulatory and home blood pressure measurements Reference: Mancia G, Bombelli M, Brambilla G, et al. Hypertension. 2013 May 28. Epub ahead of print. doi:10.1161/​HYPERTENSIONAHA.111.00690.

2. Objectives of the study To compare the risk of cardiovascular (CV) and all-cause mortality in normotensive (NT), white coat hypertensive (WCH), and sustained hypertensive (HT) patients. To evaluate the risk of developing hypertension in WCH compared with NT patients.

3. What is white coat hypertension? White coat hypertension is the condition in which office, but not out-of-office, blood pressure (BP) is elevated. Out-of-office BP could be ambulatory or home BP. Office hypertension is diagnosed when office BP >140/90 mm Hg, while ambulatory BP is normal at <125/79 mm Hg and home BP is <132/83 mm Hg. In this study, the WCH group is separated into two subgroups: -True WCH (both home and ambulatory BP are normal); -Partial WCH (home or ambulatory BP is normal, the other is elevated).

4. A long-term study Data was collected from 2051 randomly selected patients: office BP, ambulatory BP, and home BP measurements. Analysis over a 16-year follow-up of CV and all-cause mortality.

5. Increasing CV and all-cause mortality in WCH patients Rate of events Rate of events

6. A larger proportion of WCH patients develop hypertension

7. Conclusions The risk of CV and all-cause mortality was significantly increased in WCH patients compared with normotensives, especially in partial WCH patients. The guidelines of the European Society of Cardiology and the European Society of Hypertension suggest follow-up of WCH patients, and to treat them if needed. The risk of developing hypertension is also elevated in WCH patients.