1. Lein Applied Diagnostics Low Cost Sensing in the Eye

2. Lein Applied Diagnostics The Eye

3. Lein Applied Diagnostics Eye Diseases and Disorders  Cataract  Glaucoma  Refractive error  Macular degeneration  Diabetes

4. Lein Applied Diagnostics Current Solutions

5. Lein Applied Diagnostics Confocal Optical Principle Axial resolution = 1.4 λ n NA 2

6. Lein Applied Diagnostics Material Intensity Scanning Lens Position Detector

7. Lein Applied Diagnostics Thickness Measurements Position Signal Amplitude

8. Lein Applied Diagnostics Thickness Measurements (2) Thickness (microns) Number of measurements  Precision better than 1 micron

9. Lein Applied Diagnostics Low Cost Design  Innovative, modular optical design  Only 3 optical components  Simple to align

10. Lein Applied Diagnostics State of the Art

11. Lein Applied Diagnostics Platform Technology  Confocal scan - highly localised  Scan light through eye  Non invasive, non contact

12. Lein Applied Diagnostics Ophthalmic Biometry Cornea Lens Anterior Chamber

13. Lein Applied Diagnostics Auto-RefractionAuto-Refraction

14. Lens Metrology  Thickness of lenses  Measurement in aqueous solution  Lens power  IOL power

15. Lein Applied Diagnostics PharmacokineticsPharmacokinetics What the body does to the drug  liberation  absorption  metabolism  distribution  excretion

16. Lein Applied Diagnostics Other Applications  Thickness of transparent materials  Optical glass using visible light  Silicon using NIR light  Surface profiling  Particle detection

17. Lein Applied Diagnostics ConclusionsConclusions  Low cost  Accurate, precise  Non-contact  Platform technology