1. Advanced Drug Delivery John Lanzafame Biophan Technologies, Inc.

2. 2 Current Drug Delivery Most current drug delivery technologies are passive in their delivery methods Drugs are loaded and delivered over a period of time, for instance in drug elution from devices There is an opportunity to provide a more active controlled drug delivery, with advantages for certain clinical applications

3. 3 Active Drug Delivery Developing particles and particle coatings with the ability to tune properties Goal is to create particles that are tuned to respond to specific magnetic fields and wavelengths Still in materials development phase

4. 4 Material Properties Prepare different species of nanomagnetic particles (NMPs) tuned to respond to different fields Bond drug to NMPs Break bonds between drug and NMP selectively Target particles to a site by application of a magnetic field Selectively release drug by application of a magnetic field Generate heat by application of a magnetic field

5. 5 Reloading Drug Eluting Coatings Substrate Polymer Coating Concentration Gradient Controlled Magnetic Field Drug Molecules Drug bound to NMP carrier Nanomagnetic layer Passive TechnologyActive Technology

6. 6 Substrate Polymer Coating Nanomagnetic layer Controlled Magnetic Field Drug bound to NMP carrier Controlled Magnetic Field A Controlled Magnetic Field B Particle type A Drug A Particle type B Drug B Surface Elution on Demand Active Technology

7. 7 Solid tumor Apply magnetic field to concentrate particles Modulate field to release drug from particles Inject NMPs IV, NMP will circulate through the blood stream Other options: 1 - Direct injection into tumor site 2 - Coating NMP with antibodies to target Guided Drug Delivery Ability to add localized heating combined with drug delivery

8. 8 Nanolution Division Partnerships Biophan’s Nanolution division is currently collaborating with Alfred University in the development of the nanomagnetic materials The Nanolution division is also currently collaborating with NaturalNano, Inc. (OTC: NNAN) on the development of naturally occurring nanotubes for use in drug delivery systems such as transdermal patches and wound care products

9. Thank you