1. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Study flow diagram.FDA = U.S. Food and Drug Administration. * The total may exceed the number in the corresponding box because articles could be excluded for more than 1 reason at this level. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Weighted mean difference of change in postprandial glucose level with premixed insulin analogues versus other antidiabetic agents.Error bars represent 95% CIs. To convert glucose values to mmol/L, multiply by 0.0555. * Pooled results include those of a study (43) that administered insulin lispro 50/50 in the morning and afternoon and insulin lispro 75/25 in the evening. † Pooled results include those of a study (55) that administered insulin lispro 50/50 in the morning and insulin lispro 75/25 in the evening. ‡ Reference 21 was excluded. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Weighted mean difference of change in fasting glucose level with premixed insulin analogues versus other antidiabetic agents.Error bars represent 95% CIs. To convert glucose values to mmol/L, multiply by 0.0555. * Pooled results include those of a study (43) that administered insulin lispro 50/50 in the morning and afternoon and insulin lispro 75/25 in the evening. † Reference 21 was excluded. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Weighted mean difference of change in hemoglobin A 1c level with premixed insulin analogues versus other antidiabetic agents.Error bars represent 95% CIs. * Pooled results include those of a study (43) that administered insulin lispro 50/50 in the morning and afternoon and insulin lispro 75/25 in the evening. † Pooled results include those of a study (55) that administered insulin lispro 50/50 in the morning and insulin lispro 75/25 in the evening. ‡ Reference 21 was excluded. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Incidence of unclassified hypoglycemia, serious hypoglycemia, mild hypoglycemia, and symptom-only hypoglycemia with premixed insulin analogues versus other antidiabetic agents.Error bars represent 95% CIs. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 5/29/2016 From: Systematic Review: Comparative Effectiveness and Safety of Premixed Insulin Analogues in Type 2 Diabetes Ann Intern Med. 2008;149(8):549-559. doi:10.7326/0003-4819-149-8-200810210-00242 Incidence of clinical outcomes with premixed insulin analogues versus other antidiabetic agents.Error bars represent 95% CIs. * Combined outcome includes all-cause mortality and cardiovascular morbidity. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians