1. Introduction:

3. introduction Thera are 5 multigene expression based prognostic tests for breast cancer offered as reference lab test: Mammaprint,MapQuant,DX,OncotypeDX,PAM50 breast cancer intrinsic subtype classifies. Biotheranostic,a Biomreieux Company that develops oncology diagnostic tests to drive personalized treatment, reported today finding using the companies breast cancer molecular test from the study that we presented last week at the CTRC-AACR San Antonio Breast cancer symposium(SABCS).Reinforce the value of the Theros BCI as a tool that can help oncologist and patient makes information based decisions about breast cancer therapy.Especially the data that demonstrate that the theros BCI assay provides reliable quantitative and predictive information about the individual patient disease. The theros breast cancer index (BCI) is a combination of HOXB12 :IL17BR(H/1) and molecular grade index (MGI), biomarker that improve risk stratification and treatment outcomes prediction in patient with estrogen receptor ( ERS-positive, lymph node – negative breast cancer

4. 2- disease related to theros gene array test is breast cancer Breast cancer affects 1 in 10 irish women and they are currently 2400 new cases diagnosed annually.The research landscape has changed dramatically over the past 10 years before all patient diagnosed received chemotherapy.Intially as their standard treatment of case,but today with the emergence of sophisticated blood test we can personalize and tailor every patient treatment plan to reflect their particular disease thereby optimizing their outcome.

5. 3-methods Mixed methods Design to investigate complementary alternative medicine (CAM) use among women with breast cancer in Ireland New methods Consist to investigate the property of a strawberry ( by professor Micheal Stell and doctor Margaret Ritchie) Breast Lump investigation (Triple assessment used to diagnose breast cancer conditions,Including imaging and biopsy procedure (medical history,imaging,Biopsy) Imaging ( X-ray or ultrasound),biopsy(histopathology) Molecular breast imaging : is a nuclear medicine technique currently under study Blood cell counts (Haematology) Blood chemistry (CA27-29 used to predict early recurrence of disease in women with treated carcinoma of the breast

6. 4-the commercial tests or system available are : Biomerieux kit Pharmdx kit, Inform kit, CISH kit. Path Vysion kit SPoT-light kit FISH kit For antibodies used in breast cancer test are OctavaPink and OctavBlue. OctavaPink is a qualitative in vitro diagnostic test service, performed by authorized clinical laboratories OctavBlue is a qualitative in vitro diagnostic test service, performed by EventusDx authorized laboratories.

7. 5- yes there are home tests kits available : Biomerieux kit Pharmdx kit, Inform kit, CISH kit. Path Vysion kit SPoT-light kit FISH kit

8. 6- the controls are