1. Date of download: 5/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Further Insight Into the Cardiovascular Risk Calculator: The Roles of Statins, Revascularizations, and Underascertainment in the Women’s Health Study JAMA Intern Med. 2014;174(12):1964-1971. doi:10.1001/jamainternmed.2014.5336 Observed 10-Year Risk of ASCVD in the Women’s Health Study Compared With That Predicted by the ACC/AHA Pooled Cohort Equations in Clinical Risk GroupsA, Unadjusted. B, Accounting for a 25.0% reduction in ASCVD owing to statin use. C, Accounting for the intervention effect (25.0% reduction) as well as a doubling of risk in statin users owing to confounding by indication. D, Accounting for the intervention effects (25.0% reduction) and confounding by indication (doubling of risk) owing to both statin use and revascularization procedures. ACC/AHA indicates American College of Cardiology/American Heart Association; ASCVD, atherosclerotic cardiovascular disease. Figure Legend:

2. Date of download: 5/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Further Insight Into the Cardiovascular Risk Calculator: The Roles of Statins, Revascularizations, and Underascertainment in the Women’s Health Study JAMA Intern Med. 2014;174(12):1964-1971. doi:10.1001/jamainternmed.2014.5336 Calibration Plot Comparing Observed 10-Year Risk of ASCVD in the Women’s Health Study With That Predicted by the ACC/AHA Pooled Cohort Equations Within Deciles.ACC/AHA indicates American College of Cardiology/American Heart Association; ASCVD, atherosclerotic cardiovascular disease. Figure Legend:

3. Date of download: 5/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Further Insight Into the Cardiovascular Risk Calculator: The Roles of Statins, Revascularizations, and Underascertainment in the Women’s Health Study JAMA Intern Med. 2014;174(12):1964-1971. doi:10.1001/jamainternmed.2014.5336 Use of Medications and Revascularization Procedures Over Time in the Women’s Health StudyA, Proportions using statins. B, Cumulative incidence of revascularization procedures. C, Proportions using any cholesterol-lowering medications. Figure Legend:

4. Date of download: 5/29/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Further Insight Into the Cardiovascular Risk Calculator: The Roles of Statins, Revascularizations, and Underascertainment in the Women’s Health Study JAMA Intern Med. 2014;174(12):1964-1971. doi:10.1001/jamainternmed.2014.5336 Approximate Timeline of Study Baseline Data CollectionIncluding the derivation samples used for the pooled cohort equations (pooled cohort), the external validation cohorts used in the guideline report (validation 1), and additional external cohort samples (validation 2). ARIC indicates Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; CHS, Cardiovascular Health Study; MESA, Multi-Ethnic Study of Atherosclerosis; REGARDS, Reasons for Geographic and Racial Differences in Stroke; Rotterdam, Rottern study; WHI-OS, Women’s Health Study–Observational Study; WHS, Women’s Health Study. a “Contemporary” cohort. Figure Legend: