1. Table S10. A set of 140 Genes differentiating DF vs DHF (HG-U133 plus2 platform) Probeset IDGene SymbolGene Title p-value(DF vs. DHF) Fold- Change(DF vs. DHF) 213831_atHLA-DQA1major histocompatibility complex, class II, DQ alpha 10.00051624519.767 209480_atHLA-DQB1major histocompatibility complex, class II, DQ beta 10.0008316816.805 205048_s_atPSPHphosphoserine phosphatase4.78E-058.10033 238900_at HLA-DRB1 /// HLA-DRB3 /// HLA-DRB4 /// HLA-DRB5 /// LOC100294036 /// LOC100510495 major histocompatibility complex, class II, DR beta 1 /// major histocompatibility comp0.001365686.66707 236203_atHLA-DQA1major histocompatibility complex, class II, DQ alpha 10.003444536.24318 212999_x_atHLA-DQB1major histocompatibility complex, class II, DQ beta 10.001550025.07932 205826_atMYOM2myomesin (M-protein) 2, 165kDa0.0004098494.90764 1556842_atLOC286087hypothetical protein LOC2860870.0001970164.04012 204427_s_atTMED2transmembrane emp24 domain trafficking protein 20.0009937563.37729 204426_atTMED2transmembrane emp24 domain trafficking protein 20.0007566833.21407 235057_atITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.001970422.87127 232315_atZNF880zinc finger protein 8800.001358762.69436 212105_s_atDHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.000366312.66194 221268_s_atSGPP1sphingosine-1-phosphate phosphatase 10.0003806012.55887 227803_atENPP5ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)0.001496642.53451 219714_s_atCACNA2D3calcium channel, voltage-dependent, alpha 2/delta subunit 30.0008357232.49489 201143_s_atEIF2S1eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa0.01512432.48303 215894_atPTGDRprostaglandin D2 receptor (DP)0.00135172.47497 202742_s_atPRKACBprotein kinase, cAMP-dependent, catalytic, beta0.0008201652.45862 226279_atPRSS23protease, serine, 230.003509832.44016 1552610_a_atJAK1Janus kinase 10.0008191492.40744 235919_at--- 0.004123632.37912 213229_atDICER1dicer 1, ribonuclease type III0.006803192.37731 203032_s_atFHfumarate hydratase0.009829452.36684 1553530_a_atITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, M2.19E-052.34791 221830_atRAP2ARAP2A, member of RAS oncogene family4.76E-052.33406 222846_atRAB8BRAB8B, member RAS oncogene family0.01132732.33024 211654_x_atHLA-DQB1major histocompatibility complex, class II, DQ beta 10.001704782.32665 205885_s_atITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)0.001715732.32576 214544_s_atSNAP23synaptosomal-associated protein, 23kDa0.001617172.28604 219093_atPID1phosphotyrosine interaction domain containing 10.001902332.28603 204148_s_atPOMZP3 /// ZP3 POM121 and ZP3 fusion /// zona pellucida glycoprotein 3 (sperm receptor)0.0002788322.27872 222837_s_atNAA15N(alpha)-acetyltransferase 15, NatA auxiliary subunit0.004621982.27056 210910_s_atPOMZP3POM121 and ZP3 fusion0.0002672392.25018 223341_s_atSCOCshort coiled-coil protein0.0003349352.24238 203372_s_atSOCS2suppressor of cytokine signaling 20.003449552.23016 216050_at--- 0.007276412.22492 205624_atCPA3carboxypeptidase A3 (mast cell)0.001860332.21593 201946_s_atCCT2chaperonin containing TCP1, subunit 2 (beta)0.005252442.19494 212009_s_atSTIP1stress-induced-phosphoprotein 10.003911762.19084 235354_s_atRSRC1arginine/serine-rich coiled-coil 10.0003693352.1895

2. 235354_s_atRSRC1arginine/serine-rich coiled-coil 10.0003693352.1895 201681_s_atDLG5discs, large homolog 5 (Drosophila)0.000776722.17478 227394_atNCAM1neural cell adhesion molecule 10.0008326712.16895 211212_s_atORC5origin recognition complex, subunit 50.003161012.16509 200897_s_atPALLDpalladin, cytoskeletal associated protein0.001043062.16161 225219_atSMAD5SMAD family member 52.65E-052.1587 214895_s_atADAM10ADAM metallopeptidase domain 100.001217122.15448 206059_atZNF91zinc finger protein 910.00212942.1533 225688_s_atPHLDB2 pleckstrin homology-like domain, family B, member 20.0009336892.14336 225700_atGLCCI1glucocorticoid induced transcript 10.001649822.13202 205884_atITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)0.0001147382.12239 220307_atCD244CD244 molecule, natural killer cell receptor 2B45.53E-052.12106 219383_atPRR5Lproline rich 5 like0.0008021632.10692 222611_s_atPSPC1paraspeckle component 10.00643892.10478 214908_s_atTRRAP transformation/transcription domain-associated protein0.0004191782.10167 228108_atPPM1Lprotein phosphatase, Mg2+/Mn2+ dependent, 1L0.0006844772.09694 225665_atZAK sterile alpha motif and leucine zipper containing kinase AZK0.00251192.09657 202458_atPRSS23protease, serine, 230.002829722.0933 212019_atRSL1D1ribosomal L1 domain containing 10.007735732.09188 228426_atCLEC2DC-type lectin domain family 2, member D0.002849792.08109 76897_s_atFKBP15FK506 binding protein 15, 133kDa0.005665262.0776 238461_atEIF4E3 eukaryotic translation initiation factor 4E family member 30.002753322.07231 217294_s_atENO1enolase 1, (alpha)0.007579292.06558 209131_s_atSNAP23synaptosomal-associated protein, 23kDa0.003717672.05608 203908_atSLC4A4 solute carrier family 4, sodium bicarbonate cotransporter, member 48.89E-052.05478 203300_x_atAP1S2adaptor-related protein complex 1, sigma 2 subunit0.0002286492.05248 215780_s_at LOC642869 /// SET SET translocation (myeloid leukemia-associated) pseudogene /// SET nuclear oncogene0.0004942012.05005 229588_atDNAJC10DnaJ (Hsp40) homolog, subfamily C, member 100.0005516972.04949 207723_s_atKLRC3killer cell lectin-like receptor subfamily C, member 30.002466742.04402 216521_s_atBRCC3BRCA1/BRCA2-containing complex, subunit 30.004967252.04297 224407_s_atMST4serine/threonine protein kinase MST40.001360262.04177 1554464_a_atCRTAPcartilage associated protein0.001855272.0276 209255_atKLHDC10kelch domain containing 100.004624412.02166 214545_s_atPROSC proline synthetase co-transcribed homolog (bacterial)0.004933832.02047 212979_s_atFAM115Afamily with sequence similarity 115, member A0.0007995372.01342 219008_atC2orf43chromosome 2 open reading frame 430.001849212.00767 1558972_s_atTHEMISthymocyte selection associated0.008879822.00273 206214_atPLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)0.003350332.00222 1554834_a_atRASSF5 Ras association (RalGDS/AF-6) domain family member 50.002104212.00161 243689_s_atFSHD region gene 1 family, member B0.0032727-5.48581 227952_at---0.00603136-4.83642 234640_x_at---0.000881143-3.82703 220232_atstearoyl-CoA desaturase 50.00657973-3.73352 Table S10 Continued

3. 211565_atSH3-domain GRB2-like 30.0118101-3.72568 205782_atfibroblast growth factor 70.00291375-3.66966 1562527_athypothetical protein LOC2830270.00884888-3.6633 232538_at---0.0135617-3.30266 1570255_s_atankyrin repeat domain 20 family, member A10.00152789-3.13539 224012_at ankyrin repeat domain 20 family, member A1 /// ankyrin repeat domain 20 family, member0.00283325-3.11287 243489_at---0.0161471-3.11261 224159_x_attripartite motif-containing 40.00983066-3.01335 1560144_at---0.00939633-2.99694 1560142_atglutamate receptor, ionotropic, kainate 20.0105846-2.9736 234675_x_at---0.00911389-2.9735 224099_at potassium voltage-gated channel, subfamily H (eag-related), member 70.0076429-2.94055 231597_x_at---0.0195131-2.93068 215182_x_at---0.00478976-2.88103 205033_s_at defensin, alpha 1 /// defensin, alpha 1B /// defensin, alpha 3, neutrophil-specific0.00338385-2.74483 227174_atWD repeat domain 720.0105628-2.73284 242862_x_at---0.00227062-2.68029 220915_s_at---0.00897716-2.66447 1562755_at---0.00897083-2.60864 239963_at---0.00244059-2.54013 1561754_at---0.0156173-2.50887 1570153_atchromosome 13 open reading frame 380.00826763-2.48769 243340_at---0.0105821-2.48233 226036_x_atcaspase 2, apoptosis-related cysteine peptidase0.0110462-2.47444 233810_x_at---0.0141675-2.44175 242601_atHEPACAM family member 20.00473188-2.43689 208173_atinterferon, beta 1, fibroblast0.0010623-2.40326 206323_x_atoligophrenin 10.00506456-2.39623 242766_at---0.00359598-2.38895 237737_athypothetical LOC1002890260.00417432-2.37478 231031_atkeratinocyte growth factor-like protein 20.00548258-2.35405 207712_atB melanoma antigen0.00236211-2.32271 240988_x_at---0.0055797-2.32055 239959_x_at---0.00953363-2.3176 1562665_at---0.00183477-2.27707 222329_x_at---0.00816078-2.25019 238701_x_atchromosome 11 open reading frame 920.00774435-2.22642 1556105_at---0.000857181-2.22369 216153_x_atreversion-inducing-cysteine-rich protein with kazal motifs0.00807635-2.20928 220691_at---0.00429293-2.20059 234494_x_at---0.0113405-2.18995 208262_x_atMediterranean fever0.0104496-2.1521 244532_x_at---0.00296137-2.12785 236389_x_at---0.0101909-2.12553 219773_atNADPH oxidase 40.00161628-2.11798 1566146_x_at---0.00214783-2.10751 238876_at---0.0025546-2.09527 1566145_s_athypothetical LOC6444500.00172511-2.09037 236517_atmultiple EGF-like-domains 100.00735057-2.08902 1562596_at---0.00857189-2.08494 240122_atDIRAS family, GTP-binding RAS-like 20.00730361-2.08159 240662_at---0.00280693-2.06979 1561713_at---0.0065962-2.0648 233096_atKIAA11090.00134033-2.0597 233092_s_athypothetical LOC1002718400.00241468-2.03901 234179_at---0.00703471-2.03352 234303_s_atG protein-coupled receptor 850.00462974-2.01769 Table S10 Continued