1. MEMBRANE TRANSPORT

2. Membrane transport—movement of substances into and out of the cell Two basic methods of transport Passive transport No energy is required Active transport Cell must provide metabolic energy (ATP) CELL PHYSIOLOGY: MEMBRANE TRANSPORT

3. Diffusion Particles distribute themselves evenly within a solution Movement from high concentration to low concentration, PASSIVE TRANSPORT

4. Diffusion 1.They are small enough to pas through pores 2.They can dissolve in fatty portion of membrane 3.They are assisted by membrane carrier PASSIVE TRANSPORT

5. Simple Diffusion: unassisted lipid-soluble materials / small enough to pass through membrane pores PASSIVE TRANSPORT

9. ACTIVE TRANSPORT Extracellular fluid Cytoplasm Loss of phosphate restores the original conformation of the pump protein. K + is released to the cytoplasm and Na + sites are ready to bind Na + again; the cycle repeats. Binding of cytoplasmic Na + to the pump protein stimulates phosphorylation by ATP, which causes the pump protein to change its shape. The shape change expels Na + to the outside. Extracellular K + binds, causing release of the phosphate group. ADP Na + K+K+ K+K+ K+K+ K+K+ P P P ATP

10. ACTIVE TRANSPORT: EXOCYTOSIS

12. ACTIVE TRANSPORT: ENDOCYTOSIS Recycling of membrane and receptors (if present) to plasma membrane Cytoplasm Extracellular fluid Plasma membrane Detachment of vesicle Vesicle containing ingested material Vesicle Vesicle fusing with lysosome for digestion Release of contents to cytoplasm Lysosome Transport to plasma membrane and exocytosis of vesicle contents Plasma membrane Ingested substance Pit (a)

13. ACTIVE TRANSPORT: ENDOCYTOSIS Phagocytosis Receptor-mediated endocytosis

14. https://www.youtube.com/watch?v=dPKvHrD1eS4 https://www.youtube.com/watch?v=YfoiHrv57b0 CELL PHYSIOLOGY: MEMBRANE TRANSPORT