1. December 02 1 Vascular mortality: Age-specific hazard ratios for 20 mmHg lower usual SBP 55 345 deaths at ages 40-89

2. December 02 2 Vascular mortality: Age-specific hazard ratios for 10 mmHg lower usual DBP (  75 mmHg) 49 120 deaths at ages 40-89 

3. December 02 3 Stroke mortality rate in each decade of age versus usual SBP at the start of that decade Usual systolic blood pressure (mmHg) Stroke mortality (floating absolute risks & 95% CI) Age at risk:20 mmHg  SBP 80-8933%  risk 70-7950%  risk 60-6957%  risk 50-5962%  risk (40-4964%  risk) 11 274 deaths at ages 50 - 89

4. December 02 4 Stroke mortality rate in each decade of age versus usual DBP at the start of that decade Age at risk:10 mmHg  SBP 80-8937%  risk 70-7952%  risk 60-6960%  risk 50-5966%  risk (40-4965%  risk) 11 274 deaths at ages 50 - 89 Usual diastolic blood pressure (mmHg) 708090100110 1 2 4 8 16 32 64 128 256 Stroke mortality (floating absolute risks & 95% CI)

5. December 02 5 Stroke mortality: Age- and sex-specific hazard ratios for 20 mmHg lower usual SBP xif.ctrl: 22-MAY-2002 15:16:20.58 11 688 deaths at ages 40-89 Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

6. December 02 6 Stroke mortality (by sub-type): Age-specific hazard ratios for 20 mmHg lower usual SBP Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP 11 688 deaths at ages 40-89

7. December 02 7 IHD mortality rate in each decade of age versus usual SBP at the start of that decade Age at risk20 mmHg  SBP 80-8931%  risk 70-7940%  risk 60-6946%  risk 50-5950%  risk 40-4951%  risk 33 867 deaths at ages 40 - 89 Usual systolic blood pressure (mmHg) 120140160180 1 2 4 8 16 32 64 128 256 IHD mortality (floating absolute risks & 95% CI)

8. December 02 8 Age at risk10 mmHg  DBP 80-8930%  risk 70-7938%  risk 60-6944%  risk 50-5948%  risk 40-4953%  risk IHD mortality rate in each decade of age versus usual DBP at the start of that decade 33 867 deaths at ages 40 - 89 Usual diastolic blood pressure (mmHg) 708090100110 1 2 4 8 16 32 64 128 256 IHD mortality (floating absolute risks & 95% CI)

9. December 02 9 33 867 deaths at ages 40-89 IHD mortality: Age- and sex-specific hazard ratios for 20 mmHg lower usual SBP xif.ctrl: 22-MAY-2002 15:16:20.58 Age at risk Sex No. of deaths 40-49Male12020·50 (0·46-0·54) Female1200·40 (0·32-0·49) Both13220·49 (0·45-0·53) 50-59Male50270·50 (0·49-0·52) Female5670·49 (0·45-0·54) Both55940·50 (0·49-0·52) 60-69Male86090·55 (0·54-0·57) Female18410·50 (0·47-0·53) Both10 4500·54 (0·53-0·55) 70-79Male73840·62 (0·60-0·64) Female34680·55 (0·53-0·58) Both10 8520·60 (0·58-0·61) 80-89Male29320·69 (0·65-0·73) Female27170·64 (0·60-0·68) Both56490·67 (0·64-0·70) 0·250·350·50·71·0 Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

10. December 02 10 Other vascular mortality rate in each decade of age versus usual SBP at the start of that decade 9790 deaths at ages 50-89 Usual systolic blood pressure (mmHg) 120140160180 32 1 2 4 8 16 64 128 256 Other vascular mortality (not stroke or IHD) (floating absolute risks & 95% CI) Age at risk:20 mmHg  SBP 80-8930%  risk 70-7936%  risk 60-6947%  risk 50-5950%  risk (40-4957%  risk)

11. December 02 11 Other vascular mortality rate in each decade of age versus usual DBP at the start of that decade 9790 deaths at ages 50-89 Age at risk:10 mmHg  DBP 80-8929%  risk 70-7939%  risk 60-6951%  risk 50-5952%  risk (40-4957%  risk)

12. December 02 12 Mortality from other vascular causes (not stroke or IHD): Hazard ratios for 20 mmHg lower usual SBP 9 790 deaths at ages 40-89 Cause of death Mean age at death No. of deaths Heart Failure 687460·53 (0·48-0·59) Aortic Aneurysm 687050·55 (0·49-0·62) Hypertensive HD 686490·22 (0·20-0·25) Atherosclerosis 725080·48 (0·42-0·55) Sudden death 605530·49 (0·43-0·56) Inflammatory HD 673200·63 (0·53-0·75) Rheumatic HD 642550·74 (0·61-0·89) Other HD (excl. IHD) 6916820·62 (0·58-0·67) Pulmonary embolism 672960·72 (0·60-0·87) Other circulatory 651820·56 (0·44-0·71) 0·250·350·50·71·0 Hazard ratio (& 95% CI) for 20 mmHg lower usual systolic BP

13. December 02 13 IHD mortality rate in each decade of age versus usual mid blood pressure at the start of that decade 33 867 deaths at ages 40 - 89