1. APALIGHT 

2. APALIGHT Hexagonal structure (P63/m) Cell dimensions a=b=9,42 Å, c=6,88 Å d = 3.19 hardness 5 refraction index = 1.636 Ca 5 (PO 4 ) 3 (OH, F, Cl, CO 3 ) HYDROXYAPATITE

3. APALIGHT One of the few minerals produced and used by biological micro-environmental systems It is the major component of teeth enamel and dentine (97% of the enamel and 70% of the dentine) It is the main component of bones (70%) Ca 5 (PO 4 ) 3 (OH, F, Cl, CO 3 ) HYDROXYAPATITE VERY SAFE

4. APALIGHT Prosthesis covering Semi-permanent filler in non-surgical options in skin rejuvenation Promotes bone growth in nutraceutical products Effective in increasing bones mineral density Promotes osseointegration HYDROXYAPATITE MEDICAL APPLICATIONS

5. APALIGHT It is a new skin-friendly mineral active, belonging to the hydroxyapatites group Our tests: 1.as an active in a series of evaluations related to the anti-ageing efficacy 2.as a booster of sun protection in SPF in vivo tests (enhancing significantly UV-B ray protection) APALIGHT

6. APALIGHT IN-VIVO TEST

7. APALIGHT ANTI-AGING EFFICACY ANTI-AGING EFFICACY 6% HA vs Placebo 10 vol. ( 4 weeks) 1. Skin Roughness 2. Skin Elasticity 3. Soft-Focus effect @24°C @50% rh

8. p < 0.05 p > 0.05 APALIGHT SKIN ROUGHNESS 1 - SKIN ROUGHNESS (ANTI-AGING EFFICACY) R z = Maximum Roughness - 9.5% APALIGHT  PLACEBO %∆ of roughness SEBUMETER SM 810 Courage & Khazaka + SKIN SURFACE REPLICA and surface analysis, Monaderm,Monaco

9. p = 0.05 p > 0.05 APALIGHT 2 - SKIN ELASTICITY (ANTI-AGING EFFICACY) R2 = Overall biological elasticity + 10.3% APALIGHT  PLACEBO %∆ of elasticity CUTOMETER SEM 575, Courage & Khazaka +

10. APALIGHT SKIN ELASTICITY 2 - SKIN ELASTICITY (ANTI-AGING EFFICACY) R6 = Viscoelastic ratio - 17.1% APALIGHT  PLACEBO %∆ of viscoelasticity CUTOMETER SEM 575, Courage & Khazaka

11. S5 / Tf APALIGHT 3 – SOFT FOCUS EFFECT S5 / T0 S10 / T0S10 / Tf

12. APALIGHT Biological Mineral Skin friendly Environmentally friendly Physical a new… Sun Protection Sun Protection Agent!

13. APALIGHT CURRENT SUN FILTERS SITUATION It is well known organic chemical filters could potentially produce harmful substances under UV irradiation Inorganic physical filters (TiO 2 ), used for years, are generally considered to be inert and safe. Anyway Ti0 2 may generate a conspicuous number of ROS in aqueous solutions

14. SUN PROTECTION FACTOR (SPF) APALIGHT Colipa Standard P3 SPF 15 + 6% TiO 2 Colipa Standard P3 SPF 15 + 4.5% HA Colipa Standard P3 SPF 15 + 6% HA Sunscreen SPF 30 + 4% TiO 2 Sunscreen SPF 30 + 4% HA Sunscreen SPF 50+ + 5% TiO 2 Sunscreen SPF 50+ + 5% HA METHOD COLIPA CTFA-SA JCIA and CTFA 2006

15. APALIGHT SUNSCREEN FILTERS % P3 SPF 15SPF 30SPF 50+ ETHYLHEXYL METHOXYCINNAMATE 310 ENSULIZOLE 2.78 ETHYLHEXYL SALICYLATE 44 ETHYLHEXYL TRIAZONE 1.53 DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE 710 BUTYL METHOXYDIBENZOYLMETHANE 0.522 VERY POOR (UVB filters) (UVA filters)

16. APALIGHT SUNSCREEN EFFICACY (COLIPA P3)+ 6% TiO 2 + 4.5% HA+ 6% HA SPF 15161717.5 (Sunscreen) + 4% TiO 2 + 4% HA SPF 3034,1040,30 - (Sunscreen) + 5%TiO 2 + 5% HA SPF 50+ 65,00 66,20 - IN VIVO TESTED

17. APALIGHT SPF 15+ 9 % SPF 30+ 18 % SPF 50++ 2 % Vs TiO 2 SUN PROTECTION FACTOR

18. EDTA 0,3 MICROCRYSTALLYNE CELLULOSE/CELLULOSE GUM 1,5 C12-15 ALKYL BENZOATE 5 CETYL ALCOHOL/GLYCERYL STEARATE/PEG-75 STEARATE/CETETH-20/STEARETH-20 5 POLYESTER-7 3 CETEARETH-25 0,25 DIMETHICONE 5 CYCLOPENTASILOXANE/DIMETHICONE VINYL DIMETHICONE CROSSPOLYMER 3 CYCLOPENTASILOXANE 3 ETHYLHEXYLMETHOXYCINNAMATE 7,5 BUTYL METHOXYDIBENZOYLMETHANE 3,0 OCTOCRYLENE 2,7 METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL 9,9 APALIGHT further SUNSCREEN TESTS + 6% HA 30 SPF 30 Water as needed to reach 100% IN VIVO TESTED

19. EDTA 0,1 MICROCRYSTALLYNE CELLULOSE/CELLULOSE GUM 1,5 C12-15 ALKYL BENZOATE 5 CETYL ALCOHOL/GLYCERYL STEARATE/PEG-75 STEARATE/CETETH-20/STEARETH-20 5 POLYESTER-7 3 CETEARETH-25 0,25 DIMETHICONE 5 CYCLOPENTASILOXANE/DIMETHICONE VINYL DIMETHICONE CROSSPOLYMER 3 CYCLOPENTASILOXANE 3 ETHYLHEXYLMETHOXYCINNAMATE 7,0 BUTYL METHOXYDIBENZOYLMETHANE 3,0 OCTOCRYLENE 2,7 APALIGHT further SUNSCREEN TESTS + 6% HA 15 SPF 15 Water as needed to reach 100% IN VIVO TESTED

20. APALIGHT SPF 15SPF 17,3 + 19 % SPF 30SPF 40,3 + 35 % SUN PROTECTION FACTOR

21. APALIGHT IN VIVO AN IN VIVO TESTED EFFICACY

22. SUN PROTECTION FACTOR (SPF) APALIGHT Sunscreen 20% ZnO + 5% ZnO ZnO: Zano 10 plus (Ultra Chemical Inc.) UVA/UVB protection coated with triethoxycaprylylsilane. Sunscreen 20% ZnO + 5% HA Same ZnO + Apalight METHOD ISO 24444:2010 ONLY PHYSYCAL FILTERS (SPF16) 20 ZnO + 5% ZnO 20 ZnO + 5% HA SPF20,420,7

23. APALIGHT more features…

24. APALIGHT NO BLUE WHITE APPEARANCE

25. Is a physiological ingredient Is able to enhance UV protection Its performances are comparable or even superior to those of Titanium dioxide No blue-white appearance Antiage effect: Elasticity, Antiwrinkle, Roughness Lower cost of formula vs TiO 2 For Sun Care products or day cream APALIGHT CONCLUSION APALIGHT 

26. APALIGHT pH 7÷8 Microfine white stable suspension (28÷30% solid) or powder Around 100 nm but not nanoparticle (Cosmos) Special ionic composition FEATURES

27. APALIGHT Via Pastore 1 - 25082 Botticino Sera (Brescia) Italy Tel. +39 0302693532 - Fax. +39 0302193581 www.kalichem.it www.kalichem@kalichem.it Thank you