1. 5-1 Chapter 5 Integumentary System

2. 5-2 Integumentary System Consists of: –Skin –Hair –Nails –Glands Functions –Protection –Sensation (sensory receptors detect heat, cold, touch, pressure,pain) –Temperature regulation –Vitamin D production –Excretion Integument means “covering”

3. 5-3 Hypodermis Skin rests on this, but not a part Attaches skin to underlying muscle; supplies it with blood vessels, nerves Consists of loose connective tissue and fat Types of cells –Fibroblasts –Adipose cells –Macrophages Also called: –Subcutaneous tissue –Superficial fascia Thickens markedly when one gains weight

4. 5-4 Skin Dermis –Strong, flexible connective tissue layer attached to hypodermis –Structural strength –Two layers Reticular: Cleavage lines Papillary: Blood vessels, Fingerprints Epidermis –Layer of thick, keratinized stratified squamous epithelium that rests on dermis –4 Cell types –5 Layers or strata –Avascular 2 Major Layers

5. 5-5 Dermis and Epidermis

6. 5-6 Epidermal Cells Cell types –Keratinocytes: Produce keratin for strength and permeability –Melanocytes: Contribute to skin color –Langerhans’ cells: Part of the immune system –Merkel’s cells: Detect light touch and light pressure Desquamate: Older cells at surface slough off Keratinization: –Cells move from deeper layers to surface, change shape and become filled with keratin –Produces outer layer that resists abrasion and forms permeability layer

7. 5-7 Epidermal Strata 5 Strata, from deepest to most superficial: Stratum Basale –Deepest portion of epidermis; single layer of cuboidal or columnar cells representing the youngest keratinocytes –High mitotic activity –Melanocytes (10-25% of cells in this layer) produce melanin Stratum Spinosum –Limited mitosis –Keratin fibers and lamellar bodies accumulate –Together with stratum basale, often called stratum germinativum

8. 5-8 Epidermal Strata (cont’d) Stratum Granulosum –Keratohyalin granules accumulate in cell –Lamellar bodies release lipids; cells die Stratum Lucidum –Thin, clear zone; appears translucent –Consists of several layers of dead cells –Only present in a few areas of body Stratum Corneum –Most superficial; consists of cornified cells –25 or more layers of dead squamous cells (dandruff, flaky dry skin) Millions of dead keratinocytes rub off daily, giving us totally new epidermis every 25-45 days

9. 5-9 Epidermal Layers and Keratinization

10. 5-10 Melanin Transfer from Melanocyte to Keratinocytes

11. 5-11 Thick and Thin Skin Refers to epidermis only; not total skin thickness ( which is measured by a thickness in the dermis) Thick skin –Has all 5 epithelial strata –Stratum corneum has many layers of dead cells –Found in areas subject to pressure or friction Palms of hands, fingertips, soles of feet Thin skin –More flexible than thick skin –Stratum lucidum absent; other 4 strata are thinner –Covers rest of body –Where hair is found

12. 5-12 Skin Color Determined by 3 factors: –Pigments Melanin: Provides for protection against UV light Albinism: Deficiency or absence of pigment Carotene: Yellow pigment from carrots, corn –Blood circulating through the skin Imparts reddish hue and increases during blushing, anger, inflammation, fever, hypertension, allergy Cyanosis: Blue color caused by decrease in blood oxygen content –Thickness of Stratum Corneum Freckles, pigmented moles: local accumulations of melanin

13. 5-13

14. 5-14 Accessory Skin Structures Hair –Found everywhere on human skin except palms, soles, lips, nipples, parts of external genitalia, and distal segments of fingers and toes –Lanugo, terminal hairs, vellus hairs Glands –Sebaceous or oil glands –Sudoriferous or sweat glands –Ceruminous glands or earwax glands –Mammary glands Nails

15. 5-15 Hair Structure Composed of shaft and root –Shaft protrudes above skin surface –Root located below surface and base forms the hair bulb Has 3 concentric layers of dead keratinized epithelium –Medulla: Central axis –Cortex: Forms bulk of hair –Cuticle: Forms hair surface

16. 5-16

17. 5-17 Hair Growth, Color, and Muscles Hair Growth –Cycles Growth stage and resting stage –Growth stage-hair is formed by cells of the matrix differentiating, become keratinized and die; hair grows longer as cells add to base of hair root –Resting stage-then new cycle begins; new hair replaces old hair Hair growth varies depending on location (average 0.3mm/day) –Eyelashes grow for 30 days, rest for 105; scalp hair grows for 3 years, rests for 1-2 years –Permanent hair loss Pattern baldness most common Hair follicles lost; remaining produce vellus hair

18. 5-18 Hair Growth, Color, and Muscles (cont’d) Hair Color –Caused by varying amounts and types of melanin –Blonde hair: little black-brown melanin –Black hair: most melanin –Brown hair: intermediate amounts of melanin –Red hair: varying amounts of red melanin –Gray or white hair: with age, melanin decreases Muscles –Arrector pili: Smooth muscle cells associated with each hair follicle Muscle contraction causes hair to “stand on end”; the raised hair follicles are called “goose bumps”

19. 5-19 Oil and Sweat Glands Sebaceous glands –Holocrine glands located in dermis –Produce sebum –Oils hair and skin surface Sudoriferous glands –Merocrine sweat glands Most common Open directly onto skin through pores Numerous in palms and soles –Apocrine sweat glands Open into hair follicle Found in axillae, genitalia, around anus Cause body odor

20. 5-20 Ceruminous glands: modified merocrine sweat glands in the ear canal produce cerumen (earwax) cerumen+ hairs protect eardrum; prevent dirt and small insects from entering ears Mammary glands: modified apocrine sweat glands in breast part of female reproductive system milk production OTHER GLANDS

21. 5-21 Nails Anatomy –Nail is stratum corneum with hard keratin –Nail root proximally –Nail body distally –Eponychium or cuticle –Nail matrix: produces the nail Growth –Grow continuously (unlike hair) at an average rate of 0.5- 1.2mm per day) –Grow from base, like hair The distal end of primate digits have nails

22. 5-22 Summary of Integumentary System Functions 1. Stratified squamous epithelium of skin protects against abrasion 2. Prevents entry of microorganisms and other harmful substances into the body. Contains components of the immune system that protects against microbes 3. Melanin absorbs ultraviolet light and protects underlying structures 4. Hair protection: heat insulator; protection against ultraviolet light and abrasion; eyebrows keep sweat out of the eyes; eyelashes protect eyes from foreign objects; nose and ear hairs prevent entry of dust and other materials. 5. Nails protect the ends of digits. 6. Prevents water loss-lipids prevent diffusion of lipids

23. 5-23 Sensation Sensory receptors in all layers detect pain, heat and cold Epidermis and dermal papillae: touch receptors Dermis, deeper tissues: pain, heat, cold, touch, pressure receptors Hair follicles (but not hair): well innervated; sensory receptors near base of hair follicles sense hair movement Temperature Regulation Maintain homeostasis To cool off: blood vessels in dermis dilate (vasodilate); more blood flows close to surface; heat given off as perspiration To retain heat: blood vessels in dermis constrict (vasoconstriction); reduces surface blood flow and heat loss

24. 5-24 Functions as a hormone stimulates uptake of calcium(Ca) and phosphate(P) from small intestines promotes their release from bones reduces Ca loss from kidneys; resulting in increased blood Ca/P Ca/P needed for normal bone metabolism Ca needed for normal nerve and muscle function Vitamin D synthesis begins in the skin in response to ultraviolet light; precursor molecule 7-dehydrocholesterol; converted to cholecalciferol by UV light: released into the blood modified in liver and kidneys to active vitamin D (calcitriol) Can also be ingested and absorbed by intestines: liver, egg yolks, dairy products, fortified milk, vitamin pills Vitamin D Production

25. 5-25 Removal of waste products from the body Perspiration (sweat): water+ salts+ small amounts of waste products (urea, uric acid, ammonia) Excretion

26. 5-26 Aging Effects Skin more easily damaged; slower repair Epidermis thins; decrease of collagen in dermis Skin becomes drier Sebaceous gland activity decreases Skin sags and wrinkles Loss of fat from hypodermis; decrease in elastic fibers in dermis Functioning melanocytes decrease, but increase on hands and face as age spots Sunlight ages skin more rapidly

27. 5-27 The Rule of Nines Surface area estimations

28. 5-28 Burns Partial thickness burns –First-degree: epidermis only; red, painful and edema(swelling); sunburn, brief exposure to hot objects; heal in a week; no scar tissue –Second-degree: epidermis and dermis; red, pain, edema and blisters; heal in 2 weeks; deep dermis-several months to heal; scar tissue may appear Full thickness burns –Third-degree: e pidermis and dermis destroyed; no pain; varying colors; loss of functions of the integumentary system Skin Grafts –Split skin –Artificial skin –Cadavers or pigs Classifications

29. 5-29 Clinical Disorders of the Skin Bacterial Infections –Acne, impetigo Viral Infections –Chicken pox, German measles, cold sores, warts Fungal Infections –Ringworm, athlete’s foot, jock itch Cancer –Basal cell carcinoma (most common; least malignant) –Squamous cell carcinoma (may metastasize) –Malignant melanoma (will metastasize-starts from mole; spreads to other body sites)