1. FARMAK, a.s. CZECH REPUBLIC FARMAK, a.s. CZECH REPUBLIC

2. INTRODUCTION FARMAK, a.s. is:  Czech, privately owned, family based, independent middle-sized company with the tradition of industrial chemical production dates back to the year 1934.  Globally active  Flexible, reliable and customer oriented partner  Focused on R&D and manufacturing of:  niche API´s  advanced intermediates  fine chemicals  Supportive in dossier development

3. LOCATION FARMAK is easily accesible: Olomouc - Vienna = 190 km Olomouc - Prague = 280 km Olomouc - Brno = 80 km

4. HISTORY  1934 - start of industrial chemical production  1952 - establishment of state-owned company Farmakon (member of Spofa)  1992 - registration of joint-stock company FARMAK  1996 - Farmakon acquired by FARMAK (privatisation)  2004 - new R&D and QA/QC centre construction  2008 - installation of new cGMP kilolab  2014 - new Hall of final operations (HAFO)  2015 – new multipurpose production line installed

5. SALES AND MARKET SALES BY TERRITORIES (2015)  More than 120 business partners across the world  Export level in sales around 90%

6. HUMAN RESOURCES approx. 240 employees Structure of the employees Structure by education

7. QUALITY ASSURANCE Certified integrated system of the QC and environmental protection according to ISO9001 and ISO14001 standards.  highest level of cGMP requirements.  regular inspection by authorities: State Institute for Drug Control FDA  Other approvals all manufactured products regulatory documentation available:  DMF’s in USA, Canada, EC  Dossiers for European Certificate of Suitability (CEP)

8. CHEMICAL EXPERTISE CHEMICAL EXPERTISE  Chemistry of heterocyclic compounds (incl. thioaromates)  Grignard reactions (incl. sulphur)  Various condensations  Friedel - Crafts reactions  Halogenations  Oxidations  Catalytic hydrogenations  Esterifications  Racemic mixture separations  Phase transfer catalyzed reactions  Reductions (Zn, catalytic hydrogenations)

9. PRODUCTION FACILITIES  Facilities area: approx. 36,000 m 2  2 GMP production halls (one is FDA approved)  Hall of Final Operations  milling  micronizing  sieving  packaging  Supporting facilities  warehousing  waste water treatment  water purification Potential expansion of the facility is possible

10. PRODUCTION HALLS highest level of cGMP requirements reactors Pfaudler bag filters MAAP  Glass-lined, stainless steel jacketed reactors (250 - 6,300 litres; typical volume is 1,600 litres)  Total reactor capacity: 100 m 3  Batch size: 5 - 250 kg  Reaction temperatures: between -20 and +300 °C  Reaction pressure: between -80 and +300 kPa  Product separation - centrifuges, filters, filter/driers (some of them of Hastelloy C22)  Drying equipment (some of them of Hastelloy C22)

11. KILOLAB KILOLAB  Büchi ChemReactor CR: 2 x 60 L, 1 x 15 L  cryogenic technology (down to -90°C)  glove box  mobile pressure filter  HVAC system  utility systems: non-water heating/cooling medium process nitrogen, process vacuum, hot water  protected area for raw material dispensing  from 0.2 – 5 kg batches highest level of cGMP requirements

12. HALL OF FINAL OPERATIONS (HAFO)  milling/micronization  sieving  custom packaging  HVAC system

13. R&D and QA/QC CENTRE NMR 400 MHz  Analytical Centre – QC Department:  production sample service – raw materials, intermediates, final samples  documentation – SOP’s, analytical instructions, CoA’s  standards, stability studies, validation of methods, water and air monitoring  R&D Analytical Department  structural analyses  purity analyses/impurity profile  development of analytical methods  Instrumentation  LCMS, GCMS, GC, HPLC/TLC  Capillary Electrophoresis  NMR, UV/VIS a IR Spectrometry, XRay  DSC  Laser Particle Size Analyses (Cilas+Malvern)  Microbiological testing

14. ECOLOGY AND SAFETY Environmental policy in line with FARMAK’s strategy FARMAK:  fulfills demands of the national legislation for prevention of serious accidents  is involved in the national System of Assistance in Accidents Related to Transportation of Dangerous Materials  prepares reports on pollution  has got certified integrated system (ISO9001 and ISO14001)  operates own waste water treatment plant FARMAK, a.s. is holder of RESPONSIBLE CARE

15. CONTACT DETAILS Please feel free to contact us through our websites www.farmak.cz or at: Phone: +420 587 430 111, +420 585 547 111 Fax: +420 585 231 424, +420 585 232 368, +420 585 230 540 e-mail: ceo@farmak.cz Address: FARMAK, a. s. Na vlčinci 16/3, Klášterní Hradisko 779 00 OLOMOUC, CZECH REPUBLIC You can also follow us on LinkedIn - FARMAK, a.s.