1. Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2007 Year87888990919293949596 New transplant patients 86225122119253028 Deaths 116612951711 Lost to follow- up 0000000000 Alive at 31 st December 712282738576787100117 Year9798990001*020304050607 New transplant patients 33496294108114128139147127135 Deaths 1516153147305145402524 Lost to follow- up 00000000000 Alive at 31 st December 135168215278338422499592698800908 *1 patient in year transplant 2001 with no death date **Out of 1312 patients who underwent transplantation, there were 50 patients with early death before day 30 of transplant Figure 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2007

2. Table 1.1.2: New Transplant Rate per million population (pmp), 1987-2007 Year19971998199920002001200220032004200520062007 New transplant patients33496294108114128139147127135 New transplant rate pmp22344555655 Figure 1.1.2: New Transplant Rate per million population (pmp), 1987-2007 Year1987198819891990199119921993199419951996 New transplant patients86225122119253028 New transplant rate pmp0010111111

3. Table 1.1.3: Distribution of Patients by Centre, 1987-2007 Year1987198819891990199119921993 No.% % % % % % % KLA00000000000000 KLP00000000000000 UKM00000000000000 SJA00001500000000 UMA00000000000015 UMP81006 2195510012100211001895 GMC00000000000000 LWE00000000000000 SJP00000000000000 ASH00000000000000 Hospital Ampang00000000000000 Others * 00000000000000 TOTAL81006 221005 121002110019100

4. Year1994199519961997199819992000 No.% % % % % % % KLA00000000006101516 KLP41610331036927163319311617 UKM000000000023910 SJA0000000000581920 UMA416723621927153111181314 UMP1768134311391545183719312223 GMC00000000000000 LWE00000000000000 SJP00001400000000 ASH00000000000000 Hospital Ampang00000000000000 Others * 00000000000000 TOTAL25100301002810033100491006210094100

5. Year200120022003200420052006 No.% % % % % % KLA20192825352741294430 2016 KLP18172018191522162114 2721 UKM121198 914101712 97 SJA17162018231821152316 2217 UMA201916141191071410 119 UMP211920182016 12139 1814 GMC0000002121 43 LWE0000006411 22 SJP00119764128 65 ASH0000000000 11 Hospital Ampang0000000000 76 Others * 0000001100 00 TOTAL108100114100128100139100147100 127100

6. Year2007Total No.% % KLA 2121116 KLP 231723418 UKM 21161048 SJA 211617213 UMA 8615612 UMP 181333225 GMC 1191 LWE 11101 SJP 54403 ASH 1120 Hospital Ampang 3425413 Others *0010 TOTAL 1351001312100 *Others include Royal Perth Hospital KLAHospital Kuala Lumpur, (Adult) KLPHospital Kuala Lumpur, Institute Paediatrics (Paed) UKMHospital Universiti Kebangsaan Malaysia SJASime Darby Medical Centre (Adult) UMAUniversity of Malaya Medical Centre (Adult) UMPUniversity of Malaya Medical Centre (Paed) GMCGleneagles Medical Centre, Penang LWELam Wah Ee Hospital, Penang SJPSime Darby Medical Centre (Paed) ASHAmpang Puteri Specialist Hospital

7. Figure 1.1.3: Distribution of Patients by Centre, 1987-2007

8. Table 1.2.1: Distribution of Patients by Gender, 1987-2007 Year19871988198919901991199219931994 GenderNo.% % % % % % % % Male 7884671255360758136213681664 Female 1132331045240542838632936 TOTAL 81006 221005 12100211001910025100 Year19951996199719981999200020012002 GenderNo.% % % % % % % % Male11371554185533673658545766616254 Female19631346154516332642404342395246 TOTAL301002810033100491006210094100108100114100 Year20032004200520062007Total GenderNo.% % % % % % Male7155836069477559876475558 Female5745564078535241483655742 TOTAL1281001391001471001271001351001312100 Figure 1.2.1: Distribution of Patients by Gender, 1987-2007

9. Table 1.2.2: Distribution of Patients by Ethnic Group, 1987-2007 Year1987198819891990199119921993 RaceNo.% % % % % % % Malay 2254671359240433419316 Chinese 56323383636075810481053 Indian 1130000001841915 Bumiputra Sabah 0000150000210316 Bumiputra Sarawak 000000000000211 Others 00000000001500 TOTAL 81006 221005 121002110019100 Year19961997199819992000 RaceNo.% % % % % Malay829927204131503335 Chinese11392061244926424851 Indian62100484677 Bumiputra Sabah0013000033 Bumiputra Sarawak31100000000 Others0039121233 TOTAL2810033100491006210094100 Year20052006 RaceNo.% % Malay54375644 Chinese67464838 Indian141097 Bumiputra Sabah5376 Bumiputra Sarawak5322 Others2154 TOTAL147100127100 3010025 17500 0000 31164 10300 47144812 237369 %No.% 19951994 2001200220032004 No.% % % % 4744373246365137 4844655765516345 87876596 11114386 11114375 33223211 108100114100128100139100 2007Total No.% % 533949338 554161147 1410998 64474 11262 64363 1351001312100

10. Figure 1.2.2: Distribution of Patients by Ethnic Group, 1987-2007

11. Table 1.2.3: Distribution of Patients by Age Group, 1987-2007 Year1987198819891990199119921993 Age groupNo.% % % % % % % 0-94504671777510010831571947 10-19450233523002176291053 20-3900000000000000 40-5900000000000000 ≥6000000000000000 TOTAL81006 221005 121002110019100 Mean9786679 SD4333445 Median98866610 Minimum2212111 Maximum1510139 1417 Year1994199519961997199819992000 Age groupNo.% %.No.% % % % % 0-91144124013461958214328452729 10-19114413431243824163315242729 20-3931241331151512241219 20 40-5900130013007112021 ≥6000000000000011 TOTAL25100301002810033100491006210094100 Mean11131112131723 SD79912101517 Median11 6101118 Minimum13115 months11 Maximum29413745395761

12. Year200120022003200420052006 Age groupNo.% % % % % % 0-9232130264233261929204031 10-19282625221814412931212620 20-39403736324737523751353124 40-59161523202116181335242520 ≥60110000211154 TOTAL108100114100128100139100147100127100 Mean23 22232624 SD16 15 1619 Median22 23202518 Minimum1 month15 months111 Maximum645552706669 Year2007Total Age groupNo.% % 0-9382842332 10-19221632225 20-39251934026 40-59392920616 ≥60118212 TOTAL1351001312100 Mean2921 SD2117 Median2716 Minimum11 month Maximum6870 Age=date of transplant – date of birth

13. ≥60 years Figure 1.2.3: Distribution of Patients by Age Group, 1987-2007

14. Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2007 Year1987198819891990199119921993 DiagnosisNo.% % % % % % % Acute leukaemia5634678362404018419632 Chronic leukaemia00001512018419211 Hypoplastic anaemia2250041800433524421 Erythrocytic disorders000015120181500 Lymphoma00000000000000 Solid tumors000000000031415 Myelodysplasia00000000000015 Haemoglobinopathy113233732120433419211 Multiple myeloma00000000000000 Others000015001800316 TOTAL81006 221005 121002110019100 Year1994199519961997199819992000 DiagnosisNo.% % % % % % % Acute leukaemia832103313461133234728453739 Chronic leukaemia4165175186 7147111314 Hypoplastic anaemia52082741451548581112 Erythrocytic disorders00001400000000 Lymphoma000000265106 1920 Solid tumors14130013245822 Myelodysplasia28000000120011 Haemoglobinopathy5205175186 244677 Multiple myeloma00000000003511 Others001300265104633 TOTAL25100301002810033100491006210094100

15. Year200120022003200420052006 DiagnosisNo.% % % % % % Acute leukaemia 48444842 3346335437 3830 Chronic leukaemia 1817191719152216139 119 Hypoplastic anaemia 76445412953 1411 Erythrocytic disorders 0011220000 00 Lymphoma 23212018282235253423 18 Solid tumors 0033220021 32 Myelodysplasia 4444326443 43 Haemoglobinopathy 44871713961611 9 Multiple myeloma 1144433285 108 Others 33336564117 1310 TOTAL 108100114100128100139100147100 127100 Year2007Total DiagnosisNo.% % Acute leukaemia 463448237 Chronic leukaemia 5416312 Hypoplastic anaemia 861169 Erythrocytic disorders 0081 Lymphoma 251922017 Solid tumors 32292 Myelodysplasia 11312 Haemoglobinopathy 10713010 Multiple myeloma 129464 Others 2519877 TOTAL 1351001312100

16. Table 1.3.1: Distribution of Patients by Graft Number, 1987-2007 Year1987198819891990199119921993 Graft numberNo.% % % % % % % 1 81006 198648097519901895 2 00002912032521015 3 00001500000000 TOTAL 81006 221005 121002110019100 Year1994199519961997199819992000 Graft numberNo.% % % % % % % 124962997281003194479661989197 214130013121233 300000013120000 TOTAL25100301002810033100491006210094100 Year200120022003200420052006 Graft numberNo.% % % % % % 1103951139912598134981219811497 2551132322222 3000000000011 TOTAL108100114100128100137100123100117100 Year2007Total Graft numberNo.% % 110798121197 222353 30040 TOTAL1091001250100

17. Figure 1.3.1: Distribution of Patients by Graft Number, 1987-2007

18. Table 1.3.2: Distribution of Patients by Transplantation Type, 1987-2007 Year1987198819891990199119921993 Type of transplantNo.% % % % % % % Allogeneic + Syngeneic 81006 219551001210020951895 Autologous 00001500001515 TOTAL81006 221005 121002110019100 Year1994199519961997199819992000 Type of transplantNo.% % % % % % % Allogeneic + Syngeneic 2496299726932782326544715660 Autologous 141327618173518293840 TOTAL 25100301002810033100491006210094100 Year200120022003200420052006 Type of transplantNo.% % % % % % Allogeneic + Syngeneic 756975668466906590618466 Autologous 333139344434493557394334 TOTAL 108100114100128100139100147100127100 Year2007TOTAL Type of transplantNo.% % Allogeneic + Syngeneic 6750893 68 Autologous 6850419 32 TOTAL 1351001312 100

19. Figure 1.3.2: Distribution of Patients by Transplantation Type, 1987-2007

20. Table 1.3.3: Type of Transplant by Centre, 1987-2007 Type of transplantAllogeneic + SyngeneicAutologousTOTAL CentreNo.% % % KLA109121022421116 KLP2052329723418 UKM56648111048 SJA6371092617213 UMA10312531315612 UMP2943338933225 GMC405191 LWE9110101 SJP35451403 ASH101020 Hospital Ampang131287413 Others*100010 TOTAL8931004191001312100 * Others include Royal Perth Hospital

21. Figure 1.3.3: Type of Transplant by Centre, 1987-2007

22. Table 1.3.4: Source of Stem Cells, 1987-2007 Year19871988198919901991 Transplant sourceNo.% % % % % Marrow 81006 221005 12100 PBSC / Marrow + PBSC 0000000000 Cord blood / Marrow + cord 0000000000 TOTAL 81006 221005 12100 Year19921993199419951996 Transplant sourceNo.% % % % % Marrow2110019100251003010028100 PBSC / Marrow + PBSC0000000000 Cord blood / Marrow + cord0000000000 TOTAL2110019100251003010028100 Year19971998199920002001 Transplant sourceNo.% % % % % Marrow24732551376031333028 PBSC / Marrow + PBSC7212347233757617469 Cord blood / Marrow + cord2612236644 TOTAL33100491006210094100108100 Year20022003200420052006 Transplant sourceNo.% % % % % Marrow31274434302224161713 PBSC / Marrow + PBSC79697962100721167910079 Cord blood / Marrow + cord44549675108 TOTAL114100128100139100147100127100 2007Total No.% % 231749238 1067976458 64564 1351001312100

23. Figure 1.3.4: Source of Stem Cells, 1987-2007

24. Table 1.3.5: Distribution of Patients by HLA Match, 1987-2007 Year19871988198919901991 HLA MatchNo.% % % % % Identical 81006 211005 12100 1 AG 0000000000 2 AG 0000000000 ≥3 AG Disparate 0000000000 TOTAL 81006 211005 12100 Year19921993199419951996 HLA MatchNo.% % % % % Identical201001810023962910026100 1 AG0000140000 2 AG0000000000 ≥3 AG Disparate0000000000 TOTAL2010018100241002910026100 Year19971998199920002001 HLA MatchNo.% % % % % Identical 25933197409152936992 1 AG 2700370045 2 AG 0013124711 ≥3 AG Disparate 0000000011 TOTAL 2710032100441005610075100

25. Year20022003200420052006 HLA MatchNo.% % % % % Identical 70937994839285947893 1 AG 3434334445 2 AG 2322441122 ≥3 AG Disparate 0000000000 TOTAL 7510084100901009010084100 Year2007TOTAL HLA MatchNo.% % Identical619184194 1 AG34303 2 AG23202 ≥3 AG Disparate1120 TOTAL67100893100

26. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2007 Year19871988198919901991 Allogeneic Donor RelationshipNo.% % % % % Sibling 81006 211005 1192 Unrelated 0000000000  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 0000000000 Others 0000000018 TOTAL 81006 211005 12100 Year19921993199419951996 Allogeneic Donor RelationshipNo.% % % % % Sibling201001810022922910026100 Unrelated0000000000  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 0000000000 Others0000280000 TOTAL2010018100241002910026100 Year19971998199920002001 Allogeneic Donor RelationshipNo.% % % % % Sibling2696321004410055987296 Unrelated1400001234  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 110000001 3 Others0000000000 TOTAL2710032100441005610075100

27. Year20022003200420052006 Allogeneic Donor RelationshipNo.% % % % % Sibling 7195819681908291 7387 Unrelated 453491089 1113  Marrow 0000111225 218  PBSC / Marrow + PBSC 000022211319  Cord blood / Marrow + cord 41003 667563873 Others 00000000 00 TOTAL 7510084100901009010084100 Year2007TOTAL Allogeneic Donor RelationshipNo.% % Sibling588784194 Unrelated913495  Marrow 111612  PBSC / Marrow + PBSC 222612  Cord blood / Marrow + cord 6673776 Others0030 TOTAL67100893100 *excluding autologous, including syngeneic

28. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2007 Year19871988198919901991 Cause of deathNo.% % % % % Sepsis 11000000001 GVHD 00000011700 Underlying disease 0000610058300 Haemorrhage 001100000000 VOD 0000000000 Organ Failure 0000000000 Interstitial pneumonitis 0000000000 Secondary malignancy 0000000000 Others 0000000000 Unknown 0000000000 TOTAL 11001 6 6 1 Year19921993199419951996 Cause of deathNo.% % % % % Sepsis 150222120423655 GVHD 00000042300 Underlying disease 00667360318327 Haemorrhage 001110021219 VOD 0000001619 Organ Failure 1500012021200 Interstitial pneumonitis 0000000000 Secondary malignancy 0000001600 Others 0000000000 Unknown 0000000000 TOTAL 21009 5 1710011100

29. Year19971998199920002001 Cause of deathNo.% % % % % Sepsis 533166402649 GVHD 00213172649 Underlying disease 960116974622723370 Haemorrhage 00160031024 VOD 0000001324 Organ Failure 1700170000 Interstitial pneumonitis 0016001324 Secondary malignancy 0000000000 Others 0000000000 Unknown 0000000000 TOTAL 1510016100151003110047100 Year20022003200420052006 Cause of deathNo.% % % % % Sepsis41314271022923832 GVHD3105 92071828 Underlying disease19642855235116401144 Haemorrhage0000252514 VOD00000000312 Organ Failure31024001200 Interstitial pneumonitis001200 25 00 Secondary malignancy000000 00 00 Others0000002500 Unknown1312121200 TOTAL3010051100451004010025100

30. Year2007Total Cause of deathNo.% % Sepsis 5218421 GVHD 144110 Underlying disease 104221554 Haemorrhage 00164 VOD 0082 Organ Failure 00123 Interstitial pneumonitis 0072 Secondary malignancy 0010 Others 833103 Unknown 0041 TOTAL 24100398100

31. Figure 1.4.1: Patient Survival by Year of Transplant, 1987-2007 Figure 1.4.2: Patient Survival by Gender, 1987-2007

32. Figure 1.4.3: Patient Survival by Age Group, 1987-2007 Figure 1.4.4: Patient Survival by Type of Transplant, 1987-2007

33. Figure 1.5.1: Disease-free Survival for Acute Myeloid Leukaemia, 1987-2007 (Allogeneic vs. Autologous) Figure 1.5.2: Disease-free Survival for Acute Lymphoblastic Leukaemia, 1987-2007 (Allogeneic)

34. Figure 1.5.3: Disease-free Survival for Thalassaemia, 1987-2007 (Allogeneic) Figure 1.5.4: Disease-free Survival for Non-Hodgkin’s Lymphoma, 1987-2007 (Allogeneic vs. Autologous)

35. Figure 1.5.5: Disease-free Survival for Hodgkin’s Disease, 1987-2007 (Autologous) Figure 1.5.6: Disease-free Survival for Chronic Myeloid Leukaemia, 1987-2007 (Allogeneic)

36. Figure 1.5.7: Disease-free Survival for Aplastic Anaemia, 1987-2007 (Allogeneic) Figure 1.5.8: Disease-free Survival by Age Group for Acute Myeloid Leukaemia, 1987-2007 Paediatric is defined as age  18 years and adult age >18 years

37. Figure 1.5.9: Disease-free Survival by Age Group for Acute Lymphoblastic Leukaemia, 1987-2007 Paediatric is defined as age  18 years and adult age >18 years Figure 1.5.10: Disease-free Survival by Age Group for Thalassaemia, 1987-2007 No adult cases reported for Thalassaemia Paediatric is defined as age  18 years and adult age >18 years

38. Figure 1.5.11: Disease-free Survival by Age Group for Non-Hodgkin’s Lymphoma, 1987-2007 Paediatric is defined as age  18 years and adult age >18 years Figure 1.5.12: Disease-free Survival by Age Group for Hodgkin’s Disease, 1987-2007 Paediatric is defined as age  18 years and adult age >18 years

39. Figure 1.5.13: Disease-free Survival by Age Group for Chronic Myeloid Leukaemia, 1987-2007 Figure 1.5.14: Disease-free Survival by Age Group for Aplastic Anaemia, 1987-2007 Paediatric is defined as age  18 years and adult age >18 years