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PSI Materials Repository S torage and distribution of materials generated by PSI centers PSI Materials Repository S torage and distribution of materials.

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Presentation on theme: "PSI Materials Repository S torage and distribution of materials generated by PSI centers PSI Materials Repository S torage and distribution of materials."— Presentation transcript:

1 PSI Materials Repository S torage and distribution of materials generated by PSI centers PSI Materials Repository S torage and distribution of materials generated by PSI centers

2  Setting Up a Materials Repository Centralize materials, remove burden of storage and distribution from PSI Centers, provide public access to materials  Scope and need  Priorities - what to store  Clones, plasmids, vectors, expression strains, protein purification protocols, assay systems, purified proteins, crystals….  Information Access, quality control, sample characterization, tracking, storage, expansion Access, quality control, sample characterization, tracking, storage, expansion Demand for samples Demand for samples  Models for Materials Repository NIGMS Human Genetic Cell Repository (since 1972) NIGMS Human Genetic Cell Repository (since 1972) Contract; stores cell lines; handles distribution  ATCC – contracts for NIH materials, cell lines, specimens  Other examples at NIH

3 Feedback Advice from PSI Centers, Advisory Committee, Potential Users Following March 2002 PSI Protein Production Mtg Need for repository? Number of requests per year? Items to be stored? No consensus – too early Responses mixed yes/no to idea of repository Information alone may be sufficient Centralized repository vs storage/distribution of materials from Centers Few requests for materials in 2002; in 2003, 0 - 500 samples distributed per Center Concerns about loss of quality control at central facility & information transfer

4 Interim Plan Set up distribution at each Center now: Set up distribution at each Center now:  September 2003 supplement awards; ~$50K DC  Support archiving, storage and distribution (technician, supplies)  Continue through pilot phase; possible transfer to central facility later Interim plan to explore needs, issues & management Interim plan to explore needs, issues & management Centers share reagent information Centers share reagent information  PEPCdb: Protein Expression, Purification and Crystallization Database  Cloning, expression and purification protocols; contact info  Revisit need for repository  Prior to end of pilot phase – early 2005  Information (PEPCdb) enough?  Set up contract for repository to store materials?  Continue storage/distribution from Centers?


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