1. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Effect of Air Pollution on Spatial Dispersion of Myocardial Repolarization in Healthy Human Volunteers J Am Coll Cardiol. 2011;57(2):198-206. doi:10.1016/j.jacc.2010.08.625 Schematic of the Human Exposure Facility Includes ambient air inlet, mixing system to regulate/maintain stable particle concentrations, impactor to remove particles >2.5 μm, 2-stage Harvard particle concentrator, sampling ports for gases/particles, and facemask delivery to seated subject inside enclosure. During filtered air exposure, a high-efficiency particulate arresting (HEPA) filter was inserted in-line. Adapted, with permission, from Lukic et al. (15). CO = carbon monoxide; CO 2 = carbon dioxide; LPM = liters per minute; NO = nitric oxide; NO 2 = nitrogen dioxide; O 3 = ozone; RH = relative humidity; SO 2 = sulfur dioxide. Figure Legend:

2. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Effect of Air Pollution on Spatial Dispersion of Myocardial Repolarization in Healthy Human Volunteers J Am Coll Cardiol. 2011;57(2):198-206. doi:10.1016/j.jacc.2010.08.625 Mean ± SE Changes in ΔcTp-e and ΔQTd for 4 Exposure Types Increases in ΔcTp-e (change in corrected T-wave peak to T-wave end interval) were observed for concentrated ambient particles + ozone (CAP + O 3 ) and increases in QT dispersion (QTd) were observed for both CAP and CAP + O 3 exposures. FA = filtered air. Figure Legend:

3. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Effect of Air Pollution on Spatial Dispersion of Myocardial Repolarization in Healthy Human Volunteers J Am Coll Cardiol. 2011;57(2):198-206. doi:10.1016/j.jacc.2010.08.625 Changes in Systolic and Diastolic BP for 4 Exposure Types Mean ± SE changes in systolic blood pressure (BP) (A) and diastolic BP (B) for 4 exposure types. Abbreviations as in Figure 2. Figure Legend: