1. Pentose Phosphate Pathway (PPP)
بيوشيمي عمومي
گروه علوم دامي دانشکده کشاورزي دانشگاه ياسوج
دکتر مختار خواجوی
Pentose Phosphate Pathway (PPP)

2. PPP Shunt
glycogen
PPP
The pentose phosphate pathway (PPP) is the source of ribose (deoxyribose), and NADPH.
NADPH is required for biosynthesis.

3. Pentose Phosphate Pathway
Shunt
Synthesize 3 pentose phosphates
Ribulose 5-P
Xylulose 5-P
Ribose 5-P (DNA/RNA)
And NADPH
(for the reduction of RNA to DNA) Or
NADPH and glycolytic intermediates
Rapidly dividing cells need lots of NADPH and DNA
High PPP activity

4. The Oxidation Stage of PPP
Allosteric
- NADPH
Major reg step
Loss of Carbon

5. The Non-Oxidation Stage of PPP
All equilibruim rxns
When cells need lot of NADPH and nucleotides
- ribulose 5-phosphate  ribose 5-phosphate
- end of pathway

6. The Non-Oxidation Stage of PPP
Convert 5C sugars into glycolytic intermediates
Can be used in glycolysis of Gluconeogenesis

7. Pentose Phosphate Pathway
Thru PPP
3 Glc-6-P + 6 NADP+ + 3 H2O 
2 Fru-6-P + G3P + 6 NADPH + 3 CO2
Allow sub regeneration
via PPP and glyconeogenesis
Recycle 6C sugar
6 ribulose 5-P
5 Glc 5-P
6 Glc-6-P + 12 NADP+ 
5 Glc-6-P + 12 NADPH + 6 CO2 + Pi
Can be metabolized in
Glycolysis or Glcneogenesis