1. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1) J Am Coll Cardiol. 1999;33(2):327-332. doi:10.1016/S0735-1097(98)00578-6 Extremity leads of a ventricular arrhythmia upon sudden arousal at 3:00 am by an alarm clock. The HERG mutation in this patient was G604S. Figure Legend:

2. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1) J Am Coll Cardiol. 1999;33(2):327-332. doi:10.1016/S0735-1097(98)00578-6 Ventricular arrhythmia upon sudden arousal at 3.00 a.m. by an alarm clock in a HERG patient (A558P). The leads given are (approximately) V1 and II. See text for discussion. Figure Legend:

3. Date of download: 5/30/2016 Copyright © The American College of Cardiology. All rights reserved. From: Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1) J Am Coll Cardiol. 1999;33(2):327-332. doi:10.1016/S0735-1097(98)00578-6 ECG recordings of the three sibs III-2, -3 and -4 and their father (II-5). Recordings from lead II, V2 and V5 have been selected. Abnormal, prolonged QT segments are present in patients II-5, III-2 and III-4. Calibrations are standard. The recording in Figure 2 is from patient III-2. Figure Legend: