1. Click to add title Click to add subtitle

2. Part 1. “Traditional Biology”

3. Agriculture, Food, Nutrition

4. Medicine & Nursing

5. Physiology

6. Pharmacy Science & Pharmacology

7. Forensics

8. Environment & Ecology

9. Occupational & Environmental Health/Safety

10. Biochemistry

11. Biology Abstracting & Indexing Services Pharmaceutisches Central-Blatt 1830 Engineering Index1884 Index Medicus1879 (MEDLINE & PubMed) Science Abstracts1898 Chemical Abstracts (SciFinder Scholar)1907 Biological and Agricultural Index 1916/18 Biological Abstracts1926 Abstracts of Bacteriology 1917-26 Botanical Abstracts 1918-26 Applied Science and Technology 1932 Abstracts Excerpta Medica1947

12. Biology A&I Services, cont. Science Citation Index1961 Genetics Abstracts * 1968 Nucleic Acid Abstracts * 1970 Amino Acid, Peptide, and Protein Abstracts1972 BIOETHICSLINE1973 Biology Digest * 1974 Biotechnology Research Abstracts * 1982 Derwent Biotechnology Abstracts1982 Current Biotechnology1983 Current Advances in Biochemistry1984 Current Advances in Genetics and 1984 Molecular Biology

13. Oncogenes and Growth Factors Abstracts * 1989 Plant Genetic Resources Abstracts1992 Current Advances in Protein Biochemistry1992 Applied Science and Technology Abstracts1993 Bioengineering Abstracts1993 Medical and Pharmaceutical Biotechnology 1993 Abstracts Scopus2004 Trend for increased specialization of topical coverage of bibliographic databases * CSA Cambridge Scientific Abstracts

14. Final Four

16. In the Library Literature Library, Information Science & Technology Abstracts with Full Text 478 Titles Journal of the American Society for Information Science & TechnologyJournal of the American Society for Information Science & Technology Journal of the American Medical Informatics Association Journal of the Medical Library Association Information Retrieval World Patent Information Medical Reference Services Quarterly

17. Growth of Literature

18. SciFinder Scholar — It’s Not Just Chemistry

19. Part 2. Digging Deeper: “The New Biology”

20. Biological Information in the Post-Genomic Era Dominated by Molecular Biology

21. It Starts with DNA — The Molecule of Life

22. WoS Journal Coverage 2005-2011: 439,459 PLoS One7512 J. Biol. Chem.7484 PNAS7076 Nucleic Acids Res.5756 J. Virology4055 Biochem. Biophys. Res.3242 Commun. J. Bacteriol.3034 BMC Genomics2926

23. A Brief History — Friedrich Mieschler “Friedrich Miesclher: The Man Who Discovered DNA” by George Wolf in Chemical Heritage 21(2):10-11,37-41, 2003 1869 (not published until 1871) Nuclein Proteins 1838 Gerardus Johannes Mulder Jöns Jakob Berzelius leukocyte nuclei from (pus) Looking for chemical composition of tissues High phosphate Sperm of Salmo salar Almost entirely nuclein

24. Albrecht Kossel Nobel Prize ~ 1910 Physiology & Medicine Physiological chemist and medical doctor Studied proteins and nucleins Discovered a protein-like composition of nucleins Also a non-protein component: nucleic acids Adenine Cytosine Guanine Thymine Uracil 1 st Nobel Prize (nucleic acids)

25. James Watson & Francis Crick 1962 DNA not a protein Erwin Chargaff Equal number of A—T bases Equal number of C—G bases Linus Pauling Helical shape of protein X-Ray crystallography Franklin’s Photo 51 Form of A, C, G, T bases Avery, MacLeod, & McCarty DNA linked to heredity DNA “transforming factor” Nobel with Maurice Wilkins

26. Rosalin Franklin — The Dark Lady of DNA Determined chemical structure of DNA by molecular structure and X-ray crystallography Photo of the DNA molecule taken by Rosalin Franklin Photo shown to Watson by Maurice Wilkins, co-worker of Franklin and who shared Nobel Award with Watson & Crick Photo 51 She didn’t know her photo was shown to them

28. Staying Current The Scientist www.the-scientist.com/ Chemical & Engineering News pubs.acs.org/cen/index.html Science www.sciencemag.org/ Nature www.nature.com/genomics/ Bio-IT World www.bio- itworld.com/index.html Nucleic Acid Research 1 st January issue—Database Reviews (became “Database Issue” 2004) Reviews and updates of database developments 40-50 articles per issue (1996 to present) 1 st July issue—Web/Internet Reviews (became “Web Servers Issue” 2004) Reviews Web servers and services 40-50 articles per issue (2003 to present) nar.oupjournals.org/contents-by-date.0.shtml

29. Books

31. Human Genome Project

32. New Biology Evolution of the “New Biology” Biology & Life Sciences Physics Chemistry Biochemistry & Medicine Polymer Physics Medicinal/Pharmacy Genetics DNA/RNA Structure & Folding Combinatorial Chemistry Cell Biology & Physiology Instrumentation Molecular & Structural Biology/Genetics Engineering Genomics Biotechnology Proteomics Robotics Laboratory Automation Informational Molecular Biology, Computational Biology, Systems Biology Chemical Biology Mathematics & Statistics Computer Science Topology & Knot Theory Hardware Configuration & Software Development A lgorithmic Theory, Gene Mapping, Micro-Array Analysis Bioinformatics Bioinformatics Information Science Applications Simulations and Modeling Visualization Data Archives

33. Growth of Genomic Data & Access

34. Managing the Data & Information www.ncbi.nlm.nih.gov Established in 1988 public databases, conducts research in computational biology develops software tools for analyzing genome data disseminates biomedical information National Center for Biotechnology Information (NCBI)

35. NCBI at a (VERY QUICK) Glance 1 gcgggcgggc gggcaggagg ccgggaggag ggaggcggcg gcggcggcgg cggcggcggc 61 gagagcccag agccagagcc cggccggggc cgagcggagc gcggcggcgg cggcggcggc 121 ggcggctggg ccgggagagg ctggcgcgcc gggcggctcc gcgaatcctc cggcatccgc 181 cccggcgggc cgcccccgcc cgcggcagcc ccccgagcag tggcccggca tcggcgcctt 241 cccggcgggc aagagtgagc catggagcta cgtgtgggga acaagtaccg cctgggacgg 301 aagatcggga gcgggtcctt cggagatatc tacctgggtg ccaacatcgc ctctggtgag 361 gaagtcgcca tcaagctgga gtgtgtgaag acaaagcacc cccagctgca catcgagagc 421 aagttctaca agatgatgca gggtggcgtg gggatcccgt ccatcaagtg gtgcggagct 481 gagggcgact acaacgtgat ggtcatggag ctgctggggc ctagcctcga ggacctgttc 541 aacttctgtt cccgcaaatt cagcctcaag acggtgctgc tcttggccga ccagatgatc 601 agccgcatcg agtatatcca ctccaagaac ttcatccacc gggacgtcaa gcccgacaac 661 ttcctcatgg ggctggggaa gaagggcaac ctggtctaca tcatcgactt cggcctggcc 721 aagaagtacc gggacgcccg cacccaccag cacattccct accgggaaaa caagaacctg 781 accggcacgg cccgctacgc ttccatcaac acgcacctgg gcattgagca aagccgtcga 841 gatgacctgg agagcctggg ctacgtgctc atgtacttca acctgggctc cctgccctgg 901 caggggctca aagcagccac caagcgccag aagtatgaac ggatcagcga gaagaagatg

36. Data Repository for ALL U.S. Genome R&D

37. NCBI Science Primer—Basics of Biology

38. Having a BLAST with NCBI

39. Chromosome Mapping

42. Database Integration

43. Training

44. Click to add title