1. The Symptom Study Overview Cohort study with nested qualitative study Set in 2 University centres: Cambridge & Durham Aim to recruit 200 cases with each cancer (lung, colorectal, pancreas) & up to 120 interviews

2. The Symptom Study Objectives To identify symptoms associated with later presentation & with later stage at diagnosis To identify other patient factors associated with later presentation or later stage at diagnosis To understand the way in which these symptoms are recognised, interpreted and acted upon by patients The findings will inform consumer awareness campaigns & underpin development of general-practice based interventions aimed at earlier diagnosis of symptomatic cancer.

3. Recruitment to END 2012 CambridgeDurham SpecialitySentReturnedSentReturned GI Total 387310075420979 Addenbrooke’s - Medical 919238-- Addenbrooke’s - Surgical 2954768-- N Tees & Hartlepool --999195 Univ Hosp N Durham --955171 Darlington Memorial --3466613 Pancreas Total 30885609 Addenbrooke’s - Jaundice 5617-- Addenbrooke’s – U/sound 6010-- Addenbrooke’s - Surgical 14144-- West Suffolk 5114-- Univ Hosp N Durham --255 Darlington Memorial --354 Respiratory Total 14723692947476 Addenbrooke’s 857236-- Papworth 615133-- N Tees & Hartlepool --16030 Univ Hosp N Durham --26539 Darlington Memorial --2522407 Total (response rate) 56531461 (26%)84271464 (17%) Overall total 14 0802925 (21%)

4. Participant recruitment Respiratory symptoms (Recruitment ended December 2012) Original target: 200 cancers; 880 participants At End of 2012: 143 Cancers, 981 Participants Colorectal symptoms (Recruitment to end March 2013) Original target: 200 cancers; 2500 participants At End of 2012: 141 Cancers, 2275 Participants

5. Pancreatic symptoms Original target: 200 cancers; 1000 participants At End of 2012: 36 cancers; 105 participants Current recruitment: Addenbrookes- HPB clinic, Fast Track Jaundice Service, Ultrasound, West Suffolk

6. Funding study extension until June 2014 to increase participant recruitment Additional recruitment at Addenbrookes & West Suffolk Hospitals Extension to further hospitals Projection of approx. 500 additional participants would be recruited

7. Study Eligibility Patients aged 40 years or older Newly referred with: abdominal pain, abdominal mass, jaundice, unexplained weight loss or any other concerns about pancreatic cancer Sent a study pack by post including invitation letter, consent form & questionnaire

8. Exact Date dd/mm/yyyy No Tick here if you didn’t tell your GP or nurse OR Exact Date dd/mm/yyyy 23/12/2010 Estimate C Here is an EXAMPLE question: Decrease in appetite Did you have this symptom? Yes X Please go to next question When did you first tell your GP or nurse? When did you first notice this? OR Estimate “3 months ago” or “June” A B OR Please complete A then B or C below

9. Study Contact Details Dr Katie Mills Research Associate Email: ko298@medschl.cam.ac.ukko298@medschl.cam.ac.uk Tel: 01223 742090 Symptom Study Website: www.medschl.cam.ac.uk/gppcru/Projects/SYMPTOMStudy www.medschl.cam.ac.uk/gppcru/Projects/SYMPTOMStudy