2. Cause Symptom Treatment Problem Conclusion Questions

3. Genetic mutation (CFTR) Produce sweat 、 digestive juice Autosomal recessive disease

4. Infancy and childhood Cannot digest Malnourished Pancreas loses its function Airways fill with mucus

5. Infertility Swollen fingers and toes

6. Treatment

7. 1.It can affect a genetic mutation called CFTR. ※ CFTR=Cystic Fibrosis Transmembrane- conductance Regulator 2. It helps chloride gateway to stay open. 3. It can fix the basic problem. 4. It can prevent from the lungs deteriorate.

8. 1.Lungs dry up 2. It sill affects pancreas and digestive tract. 3. Overly salty skin.

9. Have a mutation in which the protein Manufactured inside the cell Never makes it (CFTR) to the cell surface Can’t act as a chloride channel Try to develop drugs that would help bring it to the cell surface Ivacaftor could then pick up the process from there Problem Solution

10. Cystic fibrosis is an incurable genetic disease, but there’s an experimental drug that brings the new hope. The drug is called ivacaftor. However, there’s still a problem. The mutation makes ivacaftor doesn’t work. Therefore, researchers are trying to save this problem and help the patients to overcome the disease.

11. 1.Is there any effort we can do to help those patients who suffer strange disease? 2. If you were the patient that suffer from cystic fibrosis, what’s the difference in your life?

12. 3.Have you ever suffered a serious diesase? How did you overcome it? 4.If your friends suffer this disease, what can you do to encourage them?