1. Using a construction site as an analogy for how proteins effect phenotype Mutation Unit: The Cellular Construction Zone http://earthref.org/SCC Scripps Classroom Connection

2. Engage Overview ● Hypothesizing: ● What are proteins? ● What jobs do proteins have in the cell? ● How do protein’s different jobs affect a cell’s phenotype? ● Questioning: ● What do you think of when I say mutant? ● What causes mutants to look different? ● What are three main concepts you learned from the video? ● Multimedia: ● Brain pop video on DNA/ genes http://earthref.org/SCC Scripps Classroom Connection

3. Hypothesize 1. What are proteins? 2. What jobs do proteins have in the cell? 3. How do protein’s different jobs effect a cell’s phenotype? http://earthref.org/SCC Scripps Classroom Connection

4. http://earthref.org/SCC Scripps Classroom Connection

5. What do you think of when I say mutant? Write a sentence and/or draw a picture on your white board. Share it with your table. http://earthref.org/SCC Scripps Classroom Connection

6. What causes mutants to look different? Discuss as a table, then share out your ideas to the class. http://earthref.org/SCC Scripps Classroom Connection

7. What makes organisms look the way they do? http://earthref.org/SCC Scripps Classroom Connection

8. Explore overview ● Genetic elements and their relationships ● Matching activity ● Students match images of genetic elements with names ● Necessary materials ● 1.DNA relationships worksheet.pdf ● Cellular Construction Zone: Matching activity ● Matching activity ● Uses a construction site analogy ● Students match “protein” functions with images ● Necessary materials ● 1. Construction site matching. docx http://earthref.org/SCC Scripps Classroom Connection

9. Genetic elements and their relationships matching activity Scripps Classroom Connection http://earthref.org/SCC Base Pairs Parts of DNA that can be arranged in a code that determines a trait

10. Base Pairs parts of DNA that can be arranged in a code that determines a trait 5 1 4 2 3 Scripps Classroom Connection http://earthref.org/SCC A. E. D. C. B.

11. Chromosomes are made of condensed DNA Gene http://earthref.org/SCC Scripps Classroom Connection

12. DNA contains pairs of bases http://earthref.org/SCC Scripps Classroom Connection

13. Genes determine phenotype Tail Color Genes ? ? ? Proteins http://earthref.org/SCC Scripps Classroom Connection

14. What is a protein? Compounds made by organism’ s bodies Involved in almost everything that happens in living organisms Proteins are involved in determining phenotype Genes Proteins Lots of different functions Phenotype http://earthref.org/SCC Scripps Classroom Connection

15. Single celled organisms have phenotypes too http://earthref.org/SCC Scripps Classroom Connection

16. Cellular construction zone overview ● Activity: Matching ● Construction workers and their jobs are used to represent proteins and their roles in a cell ● Matching key ● House: A cell ● Frame of the house: Protein that determines cell shape ● Worker carrying board up ladder: Protein that transports the cell’s building blocks ● Worker building the brick wall: Protein that builds cell wall ● Worker with the megaphone: Protein that starts and stops processes http://earthref.org/SCC Scripps Classroom Connection

17. http://earthref.org/SCC

18. A.Protein that determines the cell shape B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall D. Protein that starts and stops processes E. A cell Scripps Classroom Connection http://earthref.org/SCC

19. A.Protein that determines the cell shape B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall D. Protein that starts and stops processes E. A cell 1 5 4 3 2 http://earthref.org/SCC Scripps Classroom Connection

20. E. A cell 1 5 4 3 2 D. Protein that starts and stops processes B. Protein that transports the cell’s building blocks C. Protein that builds the cell wall A. Protein that determines the cell shape http://earthref.org/SCC Scripps Classroom Connection

21. Vocabulary: ● Protein: Compounds made by organisms that are involved in almost every aspect of what happens in living organisms. ● Function: What something does, or its job. http://earthref.org/SCC Scripps Classroom Connection

22. Explain Overview ● Analysis questions, to be discussed at tables and recorded in notebooks ● What would happen to the building if the workers did their jobs differently? ● What is an example of a way a worker would change what they were doing? ● How would this change the way the building looked? ● How does a construction site represent a cell with proteins? ● What causes a mutant to look different? http://earthref.org/SCC Scripps Classroom Connection

23. http://earthref.org/SCC What would happen to the building if the workers did their jobs differently? ? ?

24. Scripps Classroom Connection http://earthref.org/SCC What is an example of a way a worker would change what they were doing? ? ?

25. Scripps Classroom Connection http://earthref.org/SCC How would this change the way the building looked? ? ?

26. Scripps Classroom Connection http://earthref.org/SCC How does a construction site represent a cell with proteins? ? ?

27. Scripps Classroom Connection http://earthref.org/SCC How does a construction site represent a cell with proteins? o The worker who builds the walls on the house is like a ------ ---- that builds ---------- in the cell. o The frame of the house is like the ---------- of the cell.

28. What causes a mutant to look different? Scripps Classroom Connection http://earthref.org/SCC