1. Available specimen depend on the stage and type of cancer Inoperable NSCLC (50%): here we have specimen from bronchoscopy (bronchial bx, brush cytology, bronchial washing cytology, transbronchial bx, transbronchial cytology) Operable NSCLC (40%): here we have specimen from bronchoscopy, as well as from the lung operation („resectate“, very big piece = source of published studies!) SCLC (= no operation; 10%): here we have specimen from bronchoscopy only

2. Clinical Histology Clinical assessment, which was used in the clinic for the patient for the treatment and derived from clinical reports of histology (not by 2 independent pathologists for the current study)

3. Definite Diagnosis Done by 2 independent pathologists for the current study –If patient operated: from removed part of the lung –If patient not operated: most reliable result from bronchoscopic sampling (bronchial bx, brush cytology, bronchial washing cytology, transbronchial bx, transbronchial cytology)

4. Biopsy Diagnosis Done by 2 independent pathologists for the current study This is the Diagnosis, which is directly and only derived from the small biopsies, which were put on microarrays „Exactly“ this tissue was analyzed on chips. We can, thus, compare the results of Biopsy Diagnosis with the results of the chips to see what the gain of information is by chipping such tissue.

5. Bronchoscopy Diagnosis Done by 2 independent pathologists for the current study This is the Diagnosis, which is directly and only derived from the bronchoscopy including the results of our „small biopsies“, which were put on microarrays, but also of cytology of different sources, which was taken on the same occasion. Sometimes the biopsy was free of tumour, but cytology showed cancer cells. We can, thus, compare the results of Bronchoscopy Diagnosis with the results of the chips of the „small biopsies“ to see what the gain of information is by chipping such tissue over standard bronchoscopy (worldwide current standard).