1. © UEG. 2012 Presentation by Towards more coordination in health research: a report on the UEG research symposium 16/11/2012 Michael Manns General Assembly Alliance for Biomedical Research, Brussels

2. © UEG. 2012 Outline presentation Introduction United European Gastroenterology (UEG) Research symposium on digestive and liver diseases, September 18, 2012, European Parliament, Brussels How could the EuCHR contribute to tackle the research challenges for digestive, liver and other diseases the Alliance represents? What European societal challenges will help the EuCHR to overcome? Towards more coordination in health research: a report on the UEG research symposium, Michael Manns2

3. © UEG. 2012 United European Gastroenterology (UEG) Towards more coordination in health research: a report on the UEG research symposium, Michael Manns, 3

4. © UEG. 2012 UEG Member Societies Towards more coordination in health research: a report on the UEG research symposium, Michael Manns 4

5. © UEG. 2012 UEG’s Mission Improving the quality of care delivered to patients with digestive and liver diseases Raising awareness of digestive and liver diseases Assurance of the quality and equality of care for patients from all social backgrounds Drawing the attention of the EU institutions and stakeholders to digestive and liver diseases Prevention of diseases to lower the economic burden To foster excellence in clinical and scientific research Towards more coordination in health research: a report on the UEG research symposium, Michael Manns5

6. © UEG. 2012 Research symposium on digestive and liver diseases, September 18, 2012, European Parliament, Brussels Towards more coordination in health research: a report on the UEG research symposium, Michael Manns6

7. © UEG. 2012 Concept Towards more coordination in health research: a report on the UEG research symposium, Michael Manns7 Main topics: Research priorities for liver diseases and digestive cancer The EuCHR and its importance for biomedical research Primary prevention Speakers: Representatives of all EU institutions Patients Industry UEG experts Target group: EU institutions Scientists Other stakeholders in the field Goals: Raise awareness for the impact of digestive and liver diseases in Europe Demonstrate the difference research could make in reducing the current burden of digestive and liver diseases

8. © UEG. 2012 Content and outcomes Key messages: Most Europeans visit a gastroenterologist or hepatologist at least once in their lifetime Digestive and liver diseases kill more than 375,000 EU citizens every year Over one third of all the acute hospital admissions are due to digestive and liver diseases In Europe one in four children is overweight and some are underweight Main presented research challenges: Find new methods and tools to diagnose and prevent the digestive and liver diseases Reduce the current high incidence and economic costs Find the cause of a number of frequently occurring and devastating digestive and liver diseases Develop save and cost effective treatment Outcomes: Strong political commitment by MEPs, European Commission and Cyprus EU Presidency Support from the research community for the presented priorities Towards more coordination in health research: a report on the UEG research symposium, Michael Manns8

9. © UEG. 2012 How could the EuCHR contribute to tackle the research challenges for digestive, liver and other diseases the Alliance represents? Towards more coordination in health research: a report on the UEG research symposium, Michael Manns9

10. 1. Cross-talk between traditional medical disciplines is needed to reduce fragmentation – the wheel has only to be invented once !! Towards more coordination in health research: a report on the UEG research symposium, Michael Manns10 Inflammation Ageing Abnormal repair Bioinformatics Genomics Trial design Cardio- vascular medicine Infectious diseases Oncology GI and Liver Metabolic Diseases Common biological mechanisms of disease Common scientific methodology Fragmented medical disciplines

11. © UEG. 2012 2. Removal of gaps in the innovation cycle Basic science Promising molecule or gene target Candidate protein biomarker Basic epidemiologic finding Towards more coordination in health research: a report on the UEG research symposium, Michael Manns11 Early translation Partnerships and collaboration (academia, government, industry) Intervention development Phase I/II trials Late translation Phase III trials Regulatory approval Partnerships Production & commercia- lisation Phase IV trials - approval for additional indications Payment mechanism(s) Dissemination To community health providers To patients and public Adoption Adoption of advance by providers, patients, public Payment mechanism(s) in place to enable adoption No EU research funding programme in place Source: NCI President‘s Panel Annual Report 2004-2005

12. © UEG. 2012 3. Reduction of duplication and consequently better allocation of resources by having national research centers work better together The EuCHR could further coordinate all the bright lights in Europe and make them work more efficiently and effectively together! Towards more coordination in health research: a report on the UEG research symposium, Michael Manns12

13. © UEG. 2012 The overall potential of the EuCHR Accelerate excellent biomedical research in Europe. Seek better coordination and strategic planning of funding programmes at European level. Define and support high-level health research programmes in order to achieve translation of findings into innovative outcomes. Address the current gaps in the Innovation Cycle. Have a bottom-up structure led by excellent scientists. Incorporate all relevant stakeholders Towards more coordination in health research: a report on the UEG research symposium, Michael Manns13

14. © UEG. 2012 What European societal challenges will help the EuCHR to overcome? Towards more coordination in health research: a report on the UEG research symposium, Michael Manns14

15. © UEG. 2012 Ageing Towards more coordination in health research: a report on the UEG research symposium, Michael Manns15 European Commission 2009 Ageing Report

16. © UEG. 2012 Maintain and potentially even improve our international position Current situation: Constantly lagging behind established research leaders (USA, Japan, South Korea) Loosing ground to newcomers (China, India) Aim: Catching up with Europe‘s main competitors while staying ahead of the newcomers Means: Investment of at least 3% of the GDP as set by the Lisbon strategy Better coordinated research through a body such as the EuCHR Towards more coordination in health research: a report on the UEG research symposium, Michael Manns16 Growth in GDP and R&D spending 2002-2007 EU vs China (The Lancet 2011)

17. © UEG. 2012 Questions and Answers Towards more coordination in health research: a report on the UEG research symposium, Michael Manns17