1. Translational Research: From Bench to Bedside Wednesday, April 24, 2013 Experimental Biology 2013 TAC Symposium Annie Whitaker, PhD Jessica Bradley, PhD LSUHSC, New Orleans For Dr. Joni Rutter

2. Objectives 1. To define translational research and the role it will play in future scientific investigation 2. To provide examples of laboratories that have been successful in establishing a translational research program 3. To have an interactive question and answer session and discussion

3. What is translational research?

4. Translational Research – A Basic Science Perspective  Translational Research  Translates basic science discoveries into clinical applications, and/or uses clinical observations to generate new research topics  Focus on the integration of activities from bench to bedside and training laboratory and clinical investigators in team-based translation improving communications with new technologies and information. http://www.ncats.nih.gov/research/cts/cts.html

5. The NIDA Drug Abuse Genetics Research “Engine” HUMAN GENETICS Discover new human genes/variants ANIMAL GENETICS Test Function Discover new animal genes/variants New candidate genes For human studies Epidemiology Clinical & Pharmacogenetics Identification  Replication  Function  Causality  Clinical Utility

6. What are examples of translational research?

7. Addiction injection: the mission to immunise drug users against dependency  Dr Kim Janda, a medicinal chemist at the Scripps Research Institute, has worked on anti-addiction vaccines over the last 25 years.  "I've tried to invent every kind of drug vaccine --cocaine, nicotine, crystal meth, heroin, even marijuana, morphine and alcohol," Janda says. "Not all of them worked." But today's experiment could make all those years of toil worthwhile.  Similar vaccines are currently being tested on patients in psychiatric clinics around the US and the Netherlands. ScienceScience 29 March 13 by Madhumita VenkataramananMadhumita Venkataramanan

8. Addressing Research Challenges  Researchers nationwide face common barriers in clinical and translational research, including:  Increased research costs and complexity.  A shortage of information systems.  Increased regulatory burdens.  Low patient recruitment and retention in clinical research studies.  Difficulties in recruiting, mentoring and retaining a critical mass of qualified clinical and translational investigators.  Barriers such as these can cause delays in achieving ideal end results. http://www.ncats.nih.gov/research/cts/cts.html

9. The NIH is committed to improving the process of bringing new treatments, preventions and diagnostics to patients faster and more economically.

10. National Center for Advancing Translational Sciences  The mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. http://www.ncats.nih.gov/research/cts/cts.html

11. Clinical and Translational Science Awards  NCATS’ Clinical and Translational Science Awards (CTSA) program seeks to strengthen the full spectrum of translational research  NIH launched the CTSA program in 2006 to:  Create academic homes for clinical and translational research.  Provide investigators and research teams with research cores, tools and a local environment that encourages and facilitates the conduct of clinical and translational research, including with community and industry partners.  Train the scientific workforce needed for the translational sciences. http://www.ncats.nih.gov/research/cts/cts.html

12. What type of awards are provided by the CTSA?

13. Formal Clinical Research Training Awards  The CTSA program supports two types of formal clinical research training awards at CTSA institutions 1. KL2 Mentored Clinical Research Scholar Program 2. TL1 Clinical Research Training Program http://www.ncats.nih.gov/research/cts/cts.html

14. KL2 Mentored Clinical Research Scholar Program  Provides institutional support to provide mentored research career development to clinical investigators who have recently completed professional training and who are commencing basic, translational and/or clinical research.  Selects KL2 candidates providing them with a rich career development experience in a multidisciplinary setting.  KL2 appointees come from a variety of fields (e.g., medicine, dentistry, nursing, the behavioral sciences, biostatistics and epidemiology) and can receive up to five years of career development support. http://www.ncats.nih.gov/research/cts/cts.html

15. TL1 Clinical Research Training Program  Provides institutional support to students seeking a practical research introduction to clinical and translational research.  Selects TL1 candidates providing full-time research training support for:  Predoctoral Ph.D. candidates  Health-professional doctorate-master's candidates  Postdoctoral fellows  The goal of the TL1 program is to increase the number of well- trained clinician-scientists who will assume leadership roles in the design and oversight of future clinical investigations critical to the overall mission of NCATS and the NIH. http://www.ncats.nih.gov/research/cts/cts.html

16. Where do I look for funding opportunities?

17. Grants.gov

19. Commonfund.nih.gov

21. projectreporter.nih.gov

22. Invited Speakers

23. Mike Joyner, MD  Received MD from University of Arizona  Professor of Anesthesiology and practices clinical medicine as an Anesthesiologist at the Mayo Clinic  Numerous honors including  Distinguished Investigator of the Mayo Clinic  Fulbright award  Walter B. Cannon Lecture (APS)  Research interests include  autonomic control of the circulation,  muscle blood flow, skin blood flow, exercise,  oxygen transport and metabolic regulation in humans.

24. Babbette LaMarca, PhD  Received PhD in Microbiology/Immunology and postdoctoral training in 2008 in Physiology at UMMC  Associate Professor in Pharmacology and Obstetrics & Gynecology  Peer reviewer for the AHA/Immunology Section and the Vascular Endothelial Biology Clinical Section, Preeclampsia Foundation and Career Awards for NIH/NHLBI.  She is active in the American Physiological Society, as At-Large Councilor for Membership, Water and Electrolyte Homeostasis section and Committee on Careers in Physiology.  Research focus:  How inflammation mediates renal and placental dysfunction leading to hypertension during pregnancy  Determine a role for vasoactive pathways to mediate hypertension and the development of uterine lieomyomas in female patients