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Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project by Mark B. Gerstein, Zhi John Lu, Eric L. Van Nostrand, Chao Cheng,

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Presentation on theme: "Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project by Mark B. Gerstein, Zhi John Lu, Eric L. Van Nostrand, Chao Cheng,"— Presentation transcript:

1 Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project by Mark B. Gerstein, Zhi John Lu, Eric L. Van Nostrand, Chao Cheng, Bradley I. Arshinoff, Tao Liu, Kevin Y. Yip, Rebecca Robilotto, Andreas Rechtsteiner, Kohta Ikegami, Pedro Alves, Aurelien Chateigner, Marc Perry, Mitzi Morris, Raymond K. Auerbach, Xin Feng, Jing Leng, Anne Vielle, Wei Niu, Kahn Rhrissorrakrai, Ashish Agarwal, Roger P. Alexander, Galt Barber, Cathleen M. Brdlik, Jennifer Brennan, Jeremy Jean Brouillet, Adrian Carr, Ming-Sin Cheung, Hiram Clawson, Sergio Contrino, Luke O. Dannenberg, Abby F. Dernburg, Arshad Desai, Lindsay Dick, Andréa C. Dosé, Jiang Du, Thea Egelhofer, Sevinc Ercan, Ghia Euskirchen, Brent Ewing, Elise A. Feingold, Reto Gassmann, Peter J. Good, Phil Green, Francois Gullier, Michelle Gutwein, Mark S. Guyer, Lukas Habegger, Ting Han, Jorja G. Henikoff, Stefan R. Henz, Angie Hinrichs, Heather Holster, Tony Hyman, A. Leo Iniguez, Judith Janette, Morten Jensen, Masaomi Kato, W. James Kent, Ellen Kephart, Vishal Khivansara, Ekta Khurana, John K. Kim, Paulina Kolasinska-Zwierz, Eric C. Lai, Isabel Latorre, Amber Leahey, Suzanna Lewis, Paul Lloyd, Lucas Lochovsky, Rebecca F. Lowdon, Yaniv Lubling, Rachel Lyne, Michael MacCoss, Sebastian D. Mackowiak, Marco Mangone, Sheldon McKay, Desirea Mecenas, Gennifer Merrihew, David M. Miller, Andrew Muroyama, John I. Murray, Siew-Loon Ooi, Hoang Pham, Taryn Phippen, Elicia A. Preston, Nikolaus Rajewsky, Gunnar Rätsch, Heidi Rosenbaum, Joel Rozowsky, Kim Rutherford, Peter Ruzanov, Mihail Sarov, Rajkumar Sasidharan, Andrea Sboner, Paul Scheid, Eran Segal, Hyunjin Shin, Chong Shou, Frank J. Slack, Cindie Slightam, Richard Smith, William C. Spencer, E. O. Stinson, Scott Taing, Teruaki Takasaki, Dionne Vafeados, Ksenia Voronina, Guilin Wang, Nicole L. Washington, Christina M. Whittle, Beijing Wu, Koon-Kiu Yan, Georg Zeller, Zheng Zha, Mei Zhong, Xingliang Zhou,, Julie Ahringer, Susan Strome, Kristin C. Gunsalus, Gos Micklem, X. Shirley Liu, Valerie Reinke, Stuart K. Kim, LaDeana W. Hillier, Steven Henikoff, Fabio Piano, Michael Snyder, Lincoln Stein, Jason D. Lieb, and Robert H. Waterston Science Volume 330(6012):1775-1787 December 24, 2010 Published by AAAS

2 Fig. 1 Transcriptome features and alternative splicing. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

3 Fig. 2 Expression and binding dynamics. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

4 Fig. 3 Integrated miRNA-TF regulatory network. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

5 Fig. 4 HOT regions. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

6 Fig. 5 Chromosome-scale domains of chromatin organization. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

7 Fig. 6 Chromatin patterns around genes. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

8 Fig. 7 Statistical models predicting TF-binding and gene expression from chromatin features. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

9 Fig. 8 Relative proportion of annotations among constrained sequences. Mark B. Gerstein et al. Science 2010;330:1775-1787 Published by AAAS

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