1. Summary of PK studies thru 10/1/04* * Samples analyzed thru 5/30/04

2. Immunosuppressant doses and Cmin after 2-4 weeks of rx

3. CsA Dosing by ARV and week CsA mg/dose 0 50 100 150 200 250 300 350 NVPEFV1 PI2 PIkaletraNNRTI +PI NNRTI + kaletra Wk 2Wk 12Wk 28Yr 1Yr 2

4. Kaletra AUC by week pretx W2W12W28Y1Y2 efficacy 0 50000 100000 150000 200000 250000 300000 LPVLPV + NNRTI LPV ng*h/mL 0 1000 2000 3000 4000 5000 6000 7000 RTVRTV + NNRTI RTV ng*h/mL

5. 0 5000 10000 15000 20000 25000 30000 35000 40000 NFV NFV+NNRTI AUC ng*h/mL pretx W2W12W28Y1 efficacy NFV AUC by week M8/NFV AUC by week 0 10 20 30 40 50 60 pretx21228yr 1yr 2 time AUC mcg*h/mL M8 NFV

6. NNRTI AUC by week NVP AUC ng*h/mL 0 20000 40000 60000 80000 100000 NVP NVP+ PI 0 20000 40000 60000 80000 100000 120000 EFVEFV + PI EFV AUC ng*h/mL Wk 2 Wk 12Wk 28Yr 1Yr 2 pretx efficacy