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Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes.

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Presentation on theme: "Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes."— Presentation transcript:

1 Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro by Robert Kleemann, Lars Verschuren, Bert-Jan de Rooij, Jan Lindeman, Moniek M. de Maat, Alexander J. Szalai, Hans M. G. Princen, and Teake Kooistra Blood Volume 103(11):4188-4194 June 1, 2004 ©2004 by American Society of Hematology

2 Effect of atorvastatin, simvastatin, fenofibrate, and Wy 14643 on plasma cholesterol and basal huCRP expression. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

3 Induction of huCRP expression in huCRPtg mice. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

4 Effect of atorvastatin, simvastatin, fenofibrate, and Wy 14643 on IL-1β-induced huCRP expression. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

5 Statin treatment suppresses IL-1-induced huCRP gene expression in human liver cells. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

6 Statin treatment inhibits NFκB activity. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

7 Statin treatment reduces the nuclear amount of p50-NFκB ∼ C/EBPβ complexes. Robert Kleemann et al. Blood 2004;103:4188-4194 ©2004 by American Society of Hematology

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