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RESULTS CONCLUSIONS As hypothesized and observed in some of our previous work, significant LPS-induced learning decrements were noted, including fewer.

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Presentation on theme: "RESULTS CONCLUSIONS As hypothesized and observed in some of our previous work, significant LPS-induced learning decrements were noted, including fewer."— Presentation transcript:

1 RESULTS CONCLUSIONS As hypothesized and observed in some of our previous work, significant LPS-induced learning decrements were noted, including fewer avoidance responses and decreased response efficiency. As hypothesized, antalarmin proved to be effective in attenuating the behavioral effects of LPS, as shown in avoidances, escapes, and response efficiency. Treatment with antalarmin alone had no effect on any of the behavioral, tissue, or serum measures. Behavioral effects were not due to alterations in motor ability, as shown by crossing latencies, and in later testing days when LPS-treated mice cross more frequently than control animals. Contrary to our original hypothesis, antalarmin did not affect peripheral cytokine production. However, antalarmin significantly reduced central (i.e., hippocampal) levels of IL-1 , potentially explaining the observed learning decrements. Peripheral LPS administration impairs two-way active avoidance conditioning. These cognitive effects induced by LPS can be ameliorated by antalarmin, a selective CRF receptor antagonist. The effects of antalarmin on LPS-induced cognitive deficit do not appear to be mediated via effects on corticosterone production. The effects of antalarmin on LPS-induced learning decrements appears to be due to a reduction in the production of hippocampal (but not peripheral) IL-1 . Nicolette Winn and Cheryl Stenmark Department of Psychology, Angelo State University, San Angelo, TX, 76904 Due to the significant impact of childhood abuse, much research has been conducted in order to examine how abuse during childhood is related to outcomes in adulthood. Considering that many of these outcomes are negative, it is important to consider what resources child abuse survivors are interested in using to help themselves in adulthood. The present study explores resources that may be of interest to child abuse survivors by examining an anonymous, online survey The present study also examined similarities and differences between resources desired by child abuse survivors and non-child abuse survivors. INTRODUCTION METHODS One hundred fifty-nine students (33 males, 124 females, 2 preferred not to answer) from a mid-sized public university in the southwest participated. Each participant completed an anonymous, online survey consisting of sixty-seven items that represented various learning resources as well as a brief demographic questionnaire. After completing the learning resources and demographics questionnaires, participants were asked if they identify as survivors of child abuse. The 67-tem learning resources questionnaire was rationally categorized by four Industrial-Organizational psychologists into 11 dimensions representing areas of life for which people might be interested in obtaining learning resources. RESULTS CONCLUSIONS An analysis of descriptive statistics was conducted on the separate questionnaire items and showed that differences exist between what resources are most desired by child abuse survivors and non-child abuse survivors. Child abuse survivors most desired resources related to interpersonal skills, finding a job, keeping a job, communication skills, and job applications. Non-child abuse survivors most desired resources related to finding a job, work ethic, interpersonal skills, avoiding debt, and thinking skills. With regard to the dimensions, most interesting was that non-survivors reported an interest in Finance as number two while Finance did not even make survivors’ top five. An analysis of variance also showed that there was no main effect for any of the demographic variables reported by child abuse survivors. It was expected that child abuse survivors are interested in utilizing learning resources, and it was also expected that differences about what resources are desired exist between child abuse survivors and non-survivors. Results indicated that child abuse survivors are interested in utilizing all 67 learning resources examined by the present study and that differences in desired resources exist between survivors and non-survivors of child abuse regardless of differences in the demographics examined. This research will be used in the foundation and programming development of the non-profit, No Longer Silenced Movement, and it can be used to guide the direction research and interventions designed to aid child abuse survivors.


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