1. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Lectures by Chris C. Romero PowerPoint ® Lectures for Essential Biology, Third Edition – Neil Campbell, Jane Reece, and Eric Simon Essential Biology with Physiology, Second Edition – Neil Campbell, Jane Reece, and Eric Simon CHAPTER 23 Circulation and Respiration

6. Biology and Society: Doped Up The 1998 Tour de France –Was marred by alleged use of performance- enhancing drugs by some teams. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

7. Figure 23.1

8. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The drug at the center of the controversy was erythropoietin (EPO), –A natural hormone that boosts the production of red blood cells and that can be harmful if used as a supplement.

9. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Unifying Concepts of Animal Circulation Every organism must exchange materials with its environment. –The purpose of the circulatory system is to facilitate this exchange.

10. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Open and Closed Circulatory Systems All but the simplest animals have circulatory systems with three main components: –A central pump –A vascular system –The circulating fluid

11. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Open circulatory system –The heart pumps blood into large open-ended vessels. –Fluid circulates freely among cells. –Many invertebrates, such as molluscs and arthropods have open circulatory systems.

12. Figure 23.2a

13. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Closed circulatory system –Blood is confined to vessels and is distinct from the interstitial fluid. –Earthworms, octopuses, and vertebrates have closed circulatory systems.

14. Figure 23.2b

15. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The closed circulatory system in vertebrates is called a cardiovascular system. –This system includes the heart and blood vessels.

16. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Human Cardiovascular System In the human cardiovascular system, –The central pump is the heart. –The vascular system is the blood vessels. –The circulating fluid is the blood.

17. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Path of Blood In humans and other vertebrates, the three components of the cardiovascular system are organized into a double circulation system. –There are two distinct circuits of blood flow.

18. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The pulmonary circuit carries blood between the heart and the lungs.

19. Figure 23.3a

20. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The systemic circuit carries blood between the heart and the rest of the body.

21. Figure 23.3b

22. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings A trip through the human cardiovascular system Path of Blood Flow in Mammals

23. Figure 23.4

24. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings How the Heart Works The human heart is a muscular organ about the size of a fist. –It is located under the breastbone. –It has four chambers.

25. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The path of blood flow through the human heart

26. Figure 23.5

27. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Cardiac Cycle The heart relaxes and contracts regularly: –Diastole is the relaxation phase of the heart cycle. –Systole is the contraction phase.

28. Figure 23.6

29. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Pacemaker and the Control of Heart Rate The pacemaker, or SA (sinoatrial) node, sets the tempo of the heartbeat. The pacemaker is composed of specialized muscle tissue in the wall of the right atrium.

30. Figure 23.7a

31. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The impulses sent by the pacemaker produce electrical currents that can be detected by electrodes placed on the skin. –These are recorded in an electrocardiogram (ECG or EKG).

32. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings In certain kinds of heart disease, the heart’s electrical control fails to maintain a normal rhythm. –The remedy is an artificial pacemaker.

33. Figure 23.7b

34. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Blood Vessels If the heart is the body’s “pump,” then the “plumbing” is the system of arteries, veins, and capillaries. –Arteries carry blood away from the heart. –Veins carry blood toward the heart. –Capillaries allow for exchange between the bloodstream and tissue cells.

35. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings All blood vessels are lined by a thin layer of tightly packed epithelial cells. –Structural differences in the walls of the different kinds of blood vessels correlate with their different functions.

36. Figure 23.8

37. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Blood Flow Through Arteries The force that blood exerts against the walls of your blood vessels is called blood pressure. –Blood pressure is the main force driving the blood from the heart to the capillary beds. –A pulse is the rhythmic stretching of the arteries caused by the pressure of blood forced into the arteries during systole.

38. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Optimal blood pressure for adults is below 120 systolic and below 80 diastolic. High blood pressure is persistent systolic blood pressure higher than 140 and/or diastolic blood pressure higher than 90. –It is also called hypertension.

39. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Blood Flow Through Capillary Beds At any given time, about 5–10% of your capillaries have a steady flow of blood running through them.

40. Figure 23.9a

41. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The walls of capillaries are thin and leaky. –As blood enters a capillary at the arterial end, blood pressure pushes fluid rich in oxygen, nutrients, and other substances into the interstitial fluid. –At the venous end of the capillary, CO 2 and other wastes diffuse from tissue cells and into the capillary bloodstream.

42. Figure 23.9b

43. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Blood Return Through Veins After chemicals are exchanged between the blood and body cells, blood returns to the heart via the veins. –By the time blood exits the capillaries and enters the veins, the pressure originating from the heart has dropped to near zero.

44. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings –Blood still moves through the veins against the force of gravity. –As skeletal muscles contract, they help squeeze the blood along.

45. Figure 23.10

46. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Blood The circulatory system of an adult human has about 5 L (11 pints) of blood. –Just over half of this volume is plasma. –Suspended within the plasma are several types of cellular elements.

47. Figure 23.11

48. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Red Blood Cells and Oxygen Transport Red blood cells are by far the most numerous type of blood cell. –They are also called erythrocytes. –Carbohydrate-containing molecules on the surface determine the blood type.

49. Figure 23.12a

50. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Each red blood cell contains large amounts of the protein hemoglobin. –Hemoglobin contains iron and transports oxygen throughout the body. –Anemia is an abnormally low amount of hemoglobin or a low amount of red blood cells.

51. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings White Blood Cells and Defense White blood cells fight infections and cancer. –They are also called leukocytes. –There are about 700 times fewer white blood cells than red blood cells.

52. Figure 23.12b

53. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Platelets and Blood Clotting Blood contains two components that aid in clotting: –Platelets (thrombocytes) are bits of cytoplasm pinched off from larger cells in the bone marrow. –Fibrinogen is a membrane-wrapped protein found in plasma.

54. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Platelets release molecules that convert fibrinogen into fibrin. –Fibrin is a threadlike protein. –Fibrin forms a dense network to create a patch.

55. Figure 23.12c

56. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Stem Cells and the Treatment of Leukemia New blood cells are continually formed from unspecialized stem cells found in red bone marrow. –Stem cells differentiate into red and white blood cells and the cells that produce platelets. –Bone marrow cells show great promise for the treatment of disease.

57. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Leukemia is cancer of the white blood cells. –A person with leukemia has an abnormally high number of white blood cells, most of which are defective. –Leukemia is usually fatal unless treated. –Not all cases respond to treatment.

58. The Role of the Cardiovascular System in Homeostasis The cardiovascular system performs several homeostatic functions: –Controlling chemical balance –Controlling the composition of the blood –Regulating body temperature –Distributing hormones –Defending against foreign invaders Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

59. Cardiovascular Disease Cardiovascular disease accounts for 40% of all deaths in the United States. –The leading cause of death in the United States is heart attack.

60. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings When blood exits the heart, several coronary arteries immediately branch off to supply the heart muscle. –If one or more of these arteries is blocked, the heart muscle cells will quickly die. –This is called a heart attack.

61. Figure 23.13

62. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Atherosclerosis is a chronic cardiovascular disease. –The blood vessels become impaired gradually. –Vessels are narrowed by plaques of cholesterol and other substances that form in the inner walls of arteries.

63. Figure 23.14

64. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings How can you avoid becoming a heart disease victim? –Don’t smoke. –Exercise. –Eat a heart-healthy diet.

65. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Unifying Concepts of Animal Respiration Recall that cellular respiration uses oxygen and glucose to produce water, carbon dioxide, and energy in the form of ATP. –Cells need a constant supply of oxygen and must continuously dispose of CO 2. –The respiratory system facilitates this gas exchange.

66. Figure 23.UN1

67. The Structure and Function of Respiratory Surfaces Gas exchange occurs at the respiratory surface. –This surface must be large enough to take up oxygen for every cell in the body. –Different types of organisms have different types of respiratory surfaces. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

68. Some animals use their entire outer skin as a respiratory surface.

69. Figure 23.15a

70. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings In aquatic environments, the respiratory surfaces are found in the gills. –Water is constantly pumped across the gills to facilitate gas exchange.

71. Figure 23.15b

72. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings In most land-dwelling animals, the respiratory surfaces are folded into the body. –The surfaces open to the air through narrow tubes.

73. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Insects breathe using tracheae, an extensive system of internal tubes that branch throughout the body.

74. Figure 23.15c

75. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Lungs are the most common respiratory surface of terrestrial organisms. –The lungs are located in only one part of the body. –The circulatory system transports oxygen from the respiratory surface to the rest of the body.

76. Figure 23.15d

77. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Human Respiratory System In the human respiratory system, there are three phases of gas exchange.

78. Figure 23.16

79. The Structure and Function of the Human Respiratory System Our lungs are located in the chest cavity. Air moves sequentially through the body from the mouth and nose to the bronchioles. –The bronchioles are the smallest branches of the tubes within the lungs. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

80. Figure 23.17

81. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Bronchioles dead-end in clusters of air sacs called alveoli. –Alveoli carry out the process of gas exchange in the lungs.

82. Figure 23.18

83. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Taking a Breath Breathing is the alternating process of inhalation and exhalation.

84. Figure 23.19

85. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings You can consciously speed up or slow down your breathing, –But you don’t always consciously control your breathing. Most of the time, automatic control centers in the brain regulate breathing.

86. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The breathing control centers increase or decrease breathing rate in response to CO 2 levels in the blood.

87. Figure 23.20

88. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings The Role of Hemoglobin in Gas Transport The human respiratory system relies on the circulatory system to shuttle O 2 and CO 2 between the lungs and the body’s cells.

89. Figure 23.21

90. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings There is one problem with this simple idea of gas delivery. –Oxygen does not dissolve readily in blood. –Oxygen is therefore carried in hemoglobin molecules within red blood cells. O 2 from Lungs to Blood O 2 from Blood to Lungs O 2 from Tissues to Blood O 2 from Blood to Tissues

91. Figure 23.22

92. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings A shortage of iron causes a decrease in the rate of synthesis of hemoglobin. –Iron deficiency is the most common cause of anemia.

93. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings How Smoking Affects the Lungs Every breath you take exposes your respiratory tissues to potentially damaging chemicals. –One of the worst sources of airborne pollutants is tobacco smoke.

94. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Tobacco smoke irritates the cells that line the bronchi and trachea. –This inhibits their ability to remove foreign substances from the airways.

95. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings Every year, smoking kills about 440,000 Americans. –Many smokers die from lung cancer. –Smoking can also cause emphysema.

96. Figure 23.23

97. Evolution Connection: the Move onto Land The colonization of land was one of the pivotal milestones in the history of life. –It required a number of evolutionary adaptations. –One adaptation was that gill breathing evolved into lung breathing. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

98. Lungfish represent this evolutionary transition. –They breathe through both gills and lungs.

99. Figure 23.24