2. Treatment Regimens for Pulmonary Tuberculosis Caused by Drug- Susceptible Organisms Initial PhaseContinuation Phase RegimenDrugs Interval and Doses (Minimal Duration) Drugs Interval and Doses c (Minimal Duration) 1INH, RIF, PZA, EMB 7 days/week for 56 doses (8 weeks) OR 5 days/week for 40 doses (8 weeks) d INH/RIF 7 days/week for 126 doses (18 weeks) OR 5 days/week for 90 doses (18 weeks) d INH/RIFTwice weekly for 36 doses (18 weeks) INH/RPTOnce weekly for 18 doses (18 weeks) 2INH, RIF, PZA, EMB 7 days/week for 14 doses (2 weeks) then twice weekly for 12 doses (6 weeks) OR 5 days/week for 10 doses (2 weeks) d then twice weekly for 12 doses (6 weeks) INF/RIFTwice weekly for 36 doses (18 weeks) INH/RPTOnce weekly for 18 doses (18 weeks) 3INH, RIF, PZA, EMB Three times weekly for 24 doses (8 weeks) INH/RIF Three times weekly for 54 doses (18 weeks) 4INH, RIF, EMB 7 days/week for 56 doses (8 weeks) OR 5 days/week for 40 doses (8 weeks) d INH/RIF 7 days/week for 217 doses (31 weeks) OR 5 days/week for 155 doses (31 weeks) d INH/RIFTwice weekly for 62 doses (31 weeks)

3. Drugs Used in the Treatment of Tuberculosis in Adults and Children  First line agents Isoniazid Rifampin Rifabutin Rifapentine Ethambutol Pyrazinamide Streptomycin  Second-Line Agents Cycloserine Ethionamide Amikacin Capreomycin Para-aminosalicylic acid (PAS) Levofloxacin Moxifloxacin Gatifloxacin

4. Directly Observed Therapy DOT is the practice of a health care provider or other responsible person observing as the patient ingests and swallows the TB medications. DOT is the preferred core management strategy for all patients with TB. The purpose of DOT is to ensure adherence to TB therapy. DOT not only ensures completion of therapy, but it may also reduce the risk of developing drug resistance. By improving these two factors, it also reduces the risk to the community. DOT can be administered with daily or two- to three-times-per- week regimens. It can be administered to patients in the office or clinic setting, or it be given at the patient's home, school, work, or other mutually agreed on place.

5. Treatment of Latent TB Infection (Chemoprophylaxis) Treatment of latent TB infection is effective in preventing active TB disease in persons who have positive tuberculin skin tests and in those at risk for reactivation of active TB. It is usually with daily INH alone for 6 months or RIF & INH for 3 months.