1. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults: A Cluster Randomized Controlled Trial JAMA. 2008;300(23):2731-2741. doi:10.1001/jama.2008.826

2. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults: A Cluster Randomized Controlled Trial JAMA. 2008;300(23):2731-2741. doi:10.1001/jama.2008.826 a May still opt for elemental formulation. b Clinical indications of enteral feeding intolerance include clinically significant diarrhea (see footnote c), readily apparent abdominal distension, increased abdominal girth, clinically detected aspiration, or gastric residuals >200 mL for nasogastric feeds. c Clinically significant diarrhea: liquid stools >300 mL per day or >4 loose stools per day or risk of contamination of wounds or catheters. d Medications that commonly cause diarrhea include metoclopramide, magnesium, xylitol, quinidine, aminophylline, erythromycin, phosphorus, and sorbitol. Figure Legend:

3. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults: A Cluster Randomized Controlled Trial JAMA. 2008;300(23):2731-2741. doi:10.1001/jama.2008.826 ICU indicates intensive care unit. Error bars indicate test-based 95% confidence intervals (adjusted for cluster effect). The blue portions of y-axes indicate 0% to 30%. For top and center plots, P <.05 (adjusted for cluster effect) between guideline and control groups at study days 2, 3, 4, and 5. For bottom plot, P <.05 at study day 3. Figure Legend:

4. Date of download: 6/2/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults: A Cluster Randomized Controlled Trial JAMA. 2008;300(23):2731-2741. doi:10.1001/jama.2008.826 ICU indicates intensive care unit. Error bars indicate test-based 95% confidence intervals (adjusted for cluster effect). P <.05 (adjusted for cluster effect) between guideline and control groups at study days 4 and 5. Figure Legend: