1. BLOOD
Indus Pharma

2. Blood Blood is a liquid tissue. Adult contained blood 5 – 6 Liters
pH of blood (alkaline) – 7.45

3. Function of Blood Blood performs two major functions:
Transport through the body of
Carry oxygen from the lungs & carbon dioxide to the lungs
Carry food molecules (glucose, lipids, amino acids) to tissue
Acts as a vehicle for hormones, vitamins & others chemicals
Maintains ions balance (e.g., Na+, Ca2+, HCO3-)
Drainage of wastes products like urea
Regulate the body temperature
Regulates blood pressure by changing in volume & viscosity
Defense of the body against infections and other foreign materials through WBCs.

4. Composition of Blood

5. Red Blood Cells (Erythrocytes)
These are the most numerous cells in the blood and contain a substance called Hemoglobin, which give them red color and makes up about 35% of its weight.
RBC’s has diameter 7.5 µm
Women contain RBC’s 4.8 million/mm3
Men contain RBC’s 5.4 million/mm3
Average life of RBC’s 120 days
They are flexible and able to pass through the capillaries
Red blood cells are responsible for the transport of oxygen and carbon dioxide

6. Haemoglobin

7. Quantity of Haemoglobin
Male gm/100ml of blood
Female gm/100mlblood
Children (1 y) gm/100ml of blood
Children gm/100ml of blood
(10-12yrs)

8. not just an innocent by stander.

9. Anemia?
Anemia means either Red Blood Cells are low or the amount of Hemoglobin in the RBC’s is low.”
Anemia is also defined as hemoglobin concentration < 10 g/dl

10. Iron deficiency is the most leading cause of anemia worldwide
What causes anemia
YES....
Iron deficiency is the most leading cause of anemia worldwide

11. Other Causes are? Multifetal pregnancy
Deficient absorption e.g. achlorhydria
Gastrointestinal hemorrhage
Bleeding in pregnancy
Folic acid deficiency
Use of antifolate drugs
Certain pathologies like malignant disease with
increased cell turnover, hemolysis, inflammatory
disease etc

13. Prevalence of Anemia

14. Types of Anaemia
There are several different types of anaemia, each with a specific cause and treatment, including the following:
Iron-Deficiency Anaemia: Anaemia caused by lack of iron in red blood cells
Megaloblastic (Pernicious) Anaemia: Where an inability to absorb vitamin B12 prevents the production of red blood cells and damages the spinal cord
Anaemia Of Folate Deficiency: Lack of folic acid can cause anaemia, and it can be caused by alcoholism
Hemolytic Anaemia: Anaemia caused by the destruction of red blood cells

15. Iron Deficiency & Anaemia
Iron deficiency is defined as a decreased total iron body content.
Iron deficiency anemia occurs when iron deficiency is sufficiently severe to diminish erythropoiesis and cause the development of anemia.

16. Impact of Anemia Negative effects on work capacity and Qol.
Negative effects on motor and mental development in infants, children, and adolescents.
Maternal iron deficiency anemia might cause 3 fold risk of low birth weight and preterm delivery
Five fold greater risk of maternal death.
* CDC: October 2002

17. Causes of Iron Deficiency
(a) Decreased iron intake,
(b) Increased iron loss from the body
(c) Increased iron requirements.

18. Iron Daily Loss
Each day 0.5 to 1.0mg of iron is lost in the faeces, urine and sweat.

19. Daily Requirements:10-20mg
Adult male absorbs and loses about 1 mg of iron daily.
Childbearing female loses an average of 2 mg of iron daily.
A woman loses about 500 mg of iron with each pregnancy.
Menstrual losses are highly variable, ranging from mL (4-100 mg of iron) per period.

20. Iron Daily Requirement
Children
4 to 10 mg
Adolescence
10 to 20 mg
Menstruating women
7 to 20 mg
Pregnancy & Lactation
20 to 48 mg
Men & Menopausal women
5 to 10 mg

21. Iron Polymaltose complex
The iron Polymaltose complex is a water soluble macromolecular complex of iron .
Size: molecular mass of Daltons..
This molecule is so large that diffusion through the membrane of the mucosal cells is about 40 times smaller than the one for the Ferrous salts.
The complex is stable and does not release ionic iron under physiologic conditions.

22. Structure of IPC molecule

25. Folic Acid
The minimal daily requirement is about 100mcg. The need for this is vitamin more than double during pregnancy.
Folic acid may prevent certain birth defects if taken before conception and in the early months of pregnancy
Prophylactic folic acid (400mcg daily) is recommended for all women planning a pregnancy.

26. Folic Acid Prevents Birth Defects
Research has shown that by maintaining an adequate intake of Folic acid, a women in her childbearing years may reduce
the risk of conceiving a baby with the birth defects. That’s why, “U.S public Health Service is recommending a daily intake of
Folic acid for all women capable of becoming pregnant, regardless of when they plan to do so”

27. Indofer Plus provides
Each tablet of Indofer plus contains 350mcg folic acid, sufficient to meet daily requirements of Folic Acid.

28. Indofer Tablet

30. Committed to quality
excellence & economy
Hemovit

31. At most economical price Rs. 2.10/Cap
Hemovit
Available as,
Available as,
Sustained release
formulation
At most economical price Rs. 2.10/Cap
fulfilling the motto,

32. Untoward effects of iron preparations
Iron preparations mostly affects the motility of gastrointestinal tract, as a result of which either cause diarrhea or constipation but “HEMOVIT” because of its “SUSTAINED RELEASE GRANULES” releases the drug slowly at its site resulting in:
maximum absorption
long-term safety benefits
no diarrhea and constipation

33. It has been quoted
The best preparation among ferrous salts is Ferrous Sulphate which absorbs best when the patient is fasting” Ref: Parveen Kumar. Clinical Medicine. Hematological diseases. Pg. # 362

34. Dosage
The elemental iron produced by 200 mg of ferrous sulphate is 60mg. HEMOVIT contains 150mg ferrous sulphate which provides approx. 47mg of elemental iron, so
1 capsule daily is enough to meet the iron requirements (between 20 to 48mg) required during pregnancy and lactation”

35. Additional benefits of Hemovit
Besides Iron and Folic acid, HEMOVIT also contains:
Vitamin C
Vitamin B Complex
Folic Acid

36. Price comparison 1. HEMOVIT 2.10 2. OTHERS 2.70 S.NO. PRODUCTS
M.R.P/CAP
Rs. 1.
HEMOVIT
2.10 2.
OTHERS
2.70

37. Munawar Shah
KPK Pakistan

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