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Sex Differences in Pain From Both Sides of the Syringe.

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Presentation on theme: "Sex Differences in Pain From Both Sides of the Syringe."— Presentation transcript:

1 Sex Differences in Pain From Both Sides of the Syringe

2 Who’s More Sensitive to Pain: Men or Women?

3 Prevalence of Painful Disorders by Sex Berkley, Behav. Brain Sci., 1997

4 Epidemiology of Chronic Pain States by Sex Mogil, Nat. Rev. Neurosci., 2012

5 Laboratory Experiments of Sex Differences in Pain

6 Women are More Sensitive to Pain Mogil, Nat. Rev. Neurosci., 2012

7 Male Rodents are Overwhelmingly the Subjects of Basic Science Studies of Pain

8 This is a Scandal…Why Does it Persist? Mogil and Chanda, Pain, 2005

9

10 Quantitative vs. Qualitative Sex Differences Morphine + Dextromethorphan (DXMP) Nemmani et al., Pain, 2004 Kest et al., JPET, 1999 More Pain Less Pain

11 Clinical Trials of MorphiDex ®

12 The Tip of the Iceberg?

13 Is All This Male-Specific?

14 Male-Specific Reversal of Neuropathic and Inflammatory Mechanical Allodynia by Spinally Administered Glial Inhibitors Minocycline Fluorocitrate Propentofylline More Pain Less Pain More Pain Less Pain Sorge et al., Nat. Neurosci., in press

15 The First Sex Difference in Cellular Mediation of a Non-Reproductive Phenomenon? vs.

16 Pregnancy Analgesia

17 Pregnancy Analgesia Also Involves Neuroimmunity Migraine Frequency Black: no attacks White: <1/month Hatched: 1-3/month Double: 1-3/week Sances et al., 2003 More Pain Less Pain Rosen et al., in prep. More Pain Less Pain

18 Sex Differences in Conditioned Pain?

19 Conditioned Pain Hypersensitivity in Mice More Pain Less Pain

20 Conditioned Pain Hypersensitivity…is Male-Specific

21 Conditioned Pain Hypersensitivity in Humans

22 CPH in Humans is Also Male-Specific

23 Complexities…

24 Interaction of AVPR1A Genotype with Sex and Stress in the Mediation of Capsaicin Pain Less Pain More Pain AVPR1A Genotype

25 Effect of Experimenter Sex on Pain and Stress in Rodents

26 Experimenter Presence Causes Analgesia Assay: Zymosan (0.1 mg) into both ankle joints Measure: Mouse Grimace Scale MGS Score (0-2) Less Pain More Pain Sorge et al., Nat. Meth., 2014

27 Do Mammals Have an Inborn Fear of Males?

28 Conclusions

29 Thanks to… At McGill: Dr. Shad Smith Jennifer Ritchie Susana Sotocinal Dr. Kumar Nemmani Jean-Sebastien Austin Dr. Mona Lisa Chanda Dr. Dale J. Langford Dr. Michael LaCroix-Fralish Melissa A. Farmer Ara Scorscher-Petcu Dr. Andrea L. Bailey Dr. Robert E. Sorge Jeffrey Weiskopf Alexander Tuttle Dr. Loren Martin Sarah Rosen At Illinois: Dr. Sonya (Wilson) Lehto Dr. Elissa Chesler Dr. Andrew Rankin Dr. William Lariviere Dr. Karine Bon Dr. Wan You Dr. Roger Fillingim (University of Florida) Dr. Inna Belfer (University of Pittsburgh) Dr. Wendy Sternberg (Haverford College) Dr. Claudia Campbell (Johns Hopkins University) Dr. Michael Salter (University of Toronto) Dr. Simon Beggs (University of Toronto) The Louise & Alan Edwards Foundation + 100 McGill Undergraduates

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