1. Chemicals Policy and Health (CP&H) Introduction to Ecetoc TRA GPS Risk Assessment and REACH/GHS implementation in practice Leo Heezen Cefic 30 – 31 May 2011, Kiev UKRAINE

2. Chemicals Policy and Health (CP&H) Summary Ecetoc Targeted Risk Assessment tool TRA How to obtain and install TRA tool Input modules Setting up an assessment Demonstration Toluene example 2

3. Chemicals Policy and Health (CP&H) Targeted Risk Assessment European Center of Ecotoxycology and Toxicology of Chemicals Scientific forum for chemical companies » To review and access ecotoxicology and toxicology of chemcials » Non-profit, non-commercial organisation Targeted Risk Assessment (TRA) Tier 1 exposure estimation and screening tool Integrated tool for Workers, consumers and environment Workers and Consumers exposure tools also separate, Not environmental 3

4. Chemicals Policy and Health (CP&H) TRA exposure assessment tool Simple to use exposure estimation and risk assessment tool » Easy to use exposure screening tool » Fully aligned with ECHA use descriptor system » Integrated version recommended for use » For environmental part EUSES integrated » Consumer exposure very conservative » Integrated as default in ECHA Chesar tool » SPERC s integrated 4

5. Chemicals Policy and Health (CP&H) Ecetoc TRA release May 2010 Improved exposure models Integrated HH and Env exposure estimation Downloadable Excel Alignment with ECHA use descriptors Inclusion of SPERCs Inclusion dermal exposure prediction Consumer exposure unchanged: very conservative Integrated Env exposure, following EUSES 5

6. Chemicals Policy and Health (CP&H) Process for Obtaining the TRA Available via the ECETOC website » Need to register in order that ECETOC can maintain user details to ensure they are provided with information on updates and developments Users are able to download » Excel-based tools » User guides » Supporting ECETOC Technical Reports » Related technical documentation Ability to share feedback with ECETOC and user community But ECETOC will not be providing any user support facility Request for access can be obtained via: http://www.ecetoc.org/tra 6

7. Chemicals Policy and Health (CP&H) Flowchart workflow Ecetoc TRA 7

8. Chemicals Policy and Health (CP&H) Recommended to download 8

9. Chemicals Policy and Health (CP&H) Unzip all in one folder To open, open ecetocTRAM.xls and all files will open Makro to be opened CTRL E will close all sheets 9

10. Chemicals Policy and Health (CP&H) Structure of the TRA Input module » substance data » exposure scenario data, modules for workers, consumers and environment » supporting information (‘help’ function) Output of tool » box report with outcome exposure predictions (modification/iteration) » linear report with exposure predictions and risk characterization (supports CSA) Look up tables » Tables with values for inhalation and dermal exposure » background information (PROCs, values for fugacity and modifying factors) 10

11. Chemicals Policy and Health (CP&H) Input module 11

12. Chemicals Policy and Health (CP&H) Operation mode Read substance Batch Batch mode 12

13. Chemicals Policy and Health (CP&H) Operation mode 13

14. Chemicals Policy and Health (CP&H) PhysChem properties 14

15. Chemicals Policy and Health (CP&H) Set up assessment: workers info Reference values 15

16. Chemicals Policy and Health (CP&H) Set up assessment: consumers info 16

17. Chemicals Policy and Health (CP&H) Set up assessment: environmental info 17

18. Chemicals Policy and Health (CP&H) Demonstration Toluene example Following process example: Indoor production in a closed continuous process, with occasional exposure Outdoor transfer to small containers Indoor treatment of articles by dipping 18

19. Chemicals Policy and Health (CP&H) Demonstration toluene example Production PROC 2Packaging PROC 9Dipping PROC 13 SettingIndustrial Professional Duration> 4 hrs 1 – 4 hrs Ventilation ?Indoor LEVOutdoorIndoor LEV RPENo Yes 90% Preparation-> 25%5 – 25% Tonnage1000505 Fraction0.1 ERC/SPERCERCSPERC ERC129.a STPYes No SPERC-ESVOC 4AISE 16 19

20. Chemicals Policy and Health (CP&H) Example TRA for Toluene 20

21. Chemicals Policy and Health (CP&H) Example TRA for Toluene – workers input 21

22. Chemicals Policy and Health (CP&H) Example TRA for Toluene – environmental input 22

23. Chemicals Policy and Health (CP&H) TRA demonstration Live demonstration Analyses of results 23

24. Chemicals Policy and Health (CP&H) Ecetoc TRA example, workers output Need refinement 24

25. Chemicals Policy and Health (CP&H) Ecetoc TRA Example - Environment Example (1) Issue 25

26. Chemicals Policy and Health (CP&H) Ecetoc TRA Example - Environment Example (2) Issue 26

27. Chemicals Policy and Health (CP&H) EasyTRA http://www.easytra.com/page-1-Home.html 27

28. Chemicals Policy and Health (CP&H) Download Ecetoc TRA from: http://www.ecetoc.org/tra Thank you lhe@cefic.be 28